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    HOL1 Hol1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855792, updated on 17-May-2024

    Summary

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    Gene symbol
    HOL1
    Gene description
    Hol1p
    Primary source
    FungiDB:YNR055C
    Locus tag
    YNR055C
    See related
    SGD:S000005338; AllianceGenome:SGD:S000005338
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alcohol transmembrane transporter activity and inorganic cation transmembrane transporter activity. Involved in cation transport and organic hydroxy compound transport. Located in cell periphery; fungal-type vacuole; and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See HOL1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (728426..730186, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene RNA-binding ATPase activator ESF2 Neighboring gene tRNA-Leu Neighboring gene Bio5p Neighboring gene dethiobiotin synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Amino acid substitutions in membrane-spanning domains of Hol1, a member of the major facilitator superfamily of transporters, confer nonselective cation uptake in Saccharomyces cerevisiae. Wright MB, et al. J Bacteriol, 1996 Dec. PMID 8955402, Free PMC Article
    2. HOL1 mutations confer novel ion transport in Saccharomyces cerevisiae. Gaber RF, et al. Mol Cell Biol, 1990 Feb. PMID 2405251, Free PMC Article
    3. Translational autoregulation of the S. cerevisiae high-affinity polyamine transporter Hol1. Vindu A, et al. Mol Cell, 2021 Oct 7. PMID 34375581, Free PMC Article
    4. Phylogenetic classification of the major superfamily of membrane transport facilitators, as deduced from yeast genome sequencing. Nelissen B, et al. FEBS Lett, 1995 Dec 18. PMID 8543057
    5. Evolutionary divergence in the fungal response to fluconazole revealed by soft clustering. Kuo D, et al. Genome Biol, 2010. PMID 20653936, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Translational autoregulation of the S. cerevisiae high-affinity polyamine transporter Hol1.
      Title: Translational autoregulation of the S. cerevisiae high-affinity polyamine transporter Hol1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alcohol transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables inorganic cation transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables polyamine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organic hydroxy compound transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polyamine transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell periphery HDA PubMed 
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Hol1p
    NP_014453.3
    • Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      728426..730186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183232.3 → NP_014453.3  TPA: Hol1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014453.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1N0, P53389
      UniProtKB/TrEMBL
      A0A6A5Q5Q7, A6ZSC9, B5VR80, C7GIZ0, C8ZFT4, N1NZT7
      Conserved Domains (1) summary
      cd17323
      Location:67 → 569
      MFS_Tpo1_MDR_like; Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53389.1

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