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    BIO4 dethiobiotin synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855794, updated on 17-May-2024

    Summary

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    Gene symbol
    BIO4
    Gene description
    dethiobiotin synthase
    Primary source
    FungiDB:YNR057C
    Locus tag
    YNR057C
    See related
    SGD:S000005340; AllianceGenome:SGD:S000005340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables dethiobiotin synthase activity. Involved in biotin biosynthetic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See BIO4 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (733356..734069, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Hol1p Neighboring gene Bio5p Neighboring gene adenosylmethionine-8-amino-7-oxononanoate transaminase Neighboring gene putative alpha-1,3-mannosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The reacquisition of biotin prototrophy in Saccharomyces cerevisiae involved horizontal gene transfer, gene duplication and gene clustering. Hall C, et al. Genetics, 2007 Dec. PMID 18073433, Free PMC Article
    2. Characterization of the biotin biosynthesis pathway in Saccharomyces cerevisiae and evidence for a cluster containing BIO5, a novel gene involved in vitamer uptake. Phalip V, et al. Gene, 1999 May 17. PMID 10333520
    3. Biotin sensing in Saccharomyces cerevisiae is mediated by a conserved DNA element and requires the activity of biotin-protein ligase. Pirner HM, et al. J Biol Chem, 2006 May 5. PMID 16531611
    4. Transcriptional remodeling in response to iron deprivation in Saccharomyces cerevisiae. Shakoury-Elizeh M, et al. Mol Biol Cell, 2004 Mar. PMID 14668481, Free PMC Article
    5. A nutrient-responsive pathway that determines M phase timing through control of B-cyclin mRNA stability. Messier V, et al. Cell, 2013 May 23. PMID 23706744

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dethiobiotin synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dethiobiotin synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dethiobiotin synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biotin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biotin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in biotin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biotin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dethiobiotin synthase
    NP_014455.1
    • Dethiobiotin synthetase; catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria; expression appears to be repressed at low iron levels

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      733356..734069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183234.1 → NP_014455.1  TPA: dethiobiotin synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014455.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1N2, P53630
      UniProtKB/TrEMBL
      A0A8H4BWW8, A6ZSD1, B3LPI6, B5VR82, C7GIY8, C8ZFT6, G2WLB4, N1NWV6
      Conserved Domains (1) summary
      TIGR00347
      Location:15 → 186
      bioD; dethiobiotin synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53630.1

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