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    Zfp395 zinc finger protein 395 [ Mus musculus (house mouse) ]

    Gene ID: 380912, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp395provided by MGI
    Official Full Name
    zinc finger protein 395provided by MGI
    Primary source
    MGI:MGI:2682318
    See related
    Ensembl:ENSMUSG00000034522 AllianceGenome:MGI:2682318
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm910
    Summary
    Enables cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nuclear speck. Predicted to be active in nucleus. Is expressed in several structures, including aorta; brain; endocrine gland; gallbladder; and genitourinary system. Orthologous to human ZNF395 (zinc finger protein 395). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 20.0), ovary adult (RPKM 19.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 D1; 14 34.32 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (65595796..65636379)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (65358676..65398930)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene frizzled class receptor 3 Neighboring gene STARR-seq mESC enhancer starr_36966 Neighboring gene predicted gene, 52141 Neighboring gene F-box protein 16 Neighboring gene STARR-seq mESC enhancer starr_36967 Neighboring gene predicted gene, 41178 Neighboring gene STARR-positive B cell enhancer ABC_E4114 Neighboring gene STARR-positive B cell enhancer ABC_E3120 Neighboring gene predicted gene, 48449 Neighboring gene STARR-seq mESC enhancer starr_36972 Neighboring gene STARR-positive B cell enhancer mm9_chr14:66008600-66008901 Neighboring gene prepronociceptin Neighboring gene RIKEN cDNA 9530047P18 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel MyoD enhancer-binding factor. Yamamoto M, et al. Mech Dev, 2007 Sep-Oct. PMID 17693064, Free PMC Article
    2. Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism. Shang Y, et al. PLoS Biol, 2013. PMID 23565059, Free PMC Article
    3. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Homology

    Clone Names

    • MGC60757

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 395
    Names
    papillomavirus regulatory factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199029.2 → NP_950194.2  zinc finger protein 395

      See identical proteins and their annotated locations for NP_950194.2

      Status: VALIDATED

      Source sequence(s)
      AC158983, AI425685, BY117447, BY780785, CF737135
      Consensus CDS
      CCDS49522.1
      UniProtKB/TrEMBL
      E9Q5N9, Q3U227
      Related
      ENSMUSP00000064422.7, ENSMUST00000066994.7
      Conserved Domains (1) summary
      pfam15997
      Location:4 → 110
      DUF4772; Domain of unknown function (DUF4772)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      65595796..65636379
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158689.1 → XP_036014582.1  zinc finger protein 395 isoform X1

      UniProtKB/TrEMBL
      E9Q5N9, Q3U227
      Conserved Domains (1) summary
      pfam15997
      Location:4 → 110
      DUF4772; Domain of unknown function (DUF4772)

    2. XM_011245097.3 → XP_011243399.1  zinc finger protein 395 isoform X1

      See identical proteins and their annotated locations for XP_011243399.1

      UniProtKB/TrEMBL
      E9Q5N9, Q3U227
      Conserved Domains (1) summary
      pfam15997
      Location:4 → 110
      DUF4772; Domain of unknown function (DUF4772)
    Nucleotide Protein Strain
    Heading Accession and Version

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