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    Phf19 PHD finger protein 19 [ Mus musculus (house mouse) ]

    Gene ID: 74016, updated on 8-May-2024

    Summary

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    Official Symbol
    Phf19provided by MGI
    Official Full Name
    PHD finger protein 19provided by MGI
    Primary source
    MGI:MGI:1921266
    See related
    Ensembl:ENSMUSG00000026873 AllianceGenome:MGI:1921266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3110009G19Rik; 3321402G02Rik
    Summary
    Enables methylated histone binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of histone H3-K27 methylation; and stem cell population maintenance. Part of ESC/E(Z) complex. Is expressed in brain ventricular layer; early conceptus; eye; genitourinary system; and intestine. Orthologous to human PHF19 (PHD finger protein 19). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thymus adult (RPKM 5.0), genital fat pad adult (RPKM 4.1) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Phf19 in Genome Data Viewer
    Location:
    2 B; 2 23.02 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34783764..34804365, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (34893752..34914353, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 Neighboring gene STARR-positive B cell enhancer ABC_E3369 Neighboring gene cutA divalent cation tolerance homolog-like Neighboring gene STARR-positive B cell enhancer ABC_E1003 Neighboring gene predicted gene, 24905 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:34794663-34794772 Neighboring gene STARR-seq mESC enhancer starr_04273 Neighboring gene TNF receptor-associated factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E7809 Neighboring gene predicted gene, 52552

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19. Dong C, et al. Elife, 2020 Sep 1. PMID 32869745, Free PMC Article
    2. The Polycomb-associated factor PHF19 controls hematopoietic stem cell state and differentiation. Vizán P, et al. Sci Adv, 2020 Aug. PMID 32821835, Free PMC Article
    3. PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation. Ren Z, et al. Blood, 2019 Oct 3. PMID 31383640, Free PMC Article
    4. miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8(+) T cell fate. Ji Y, et al. Nat Commun, 2019 May 14. PMID 31089138, Free PMC Article
    5. PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2. Gu W, et al. Cardiovasc Toxicol, 2021 Jun. PMID 33611744, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2.
      Title: PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2.
    2. Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19.
      Title: Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19.
    3. PHF19 is required for multiple myeloma tumorigenesis in vivo.
      Title: PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation.
    4. In B16 mouse melanoma model miR-155 enhances Polycomb repressor complex 2 (PRC2) activity indirectly by promoting the expression of the PRC2-associated factor Phf19 through downregulation of the Akt inhibitor, Ship1. Phf19 orchestrates a transcriptional program extensively shared with miR-155 to restrain T cell senescence and sustain CD8+ T cell antitumor responses.
      Title: miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8(+) T cell fate.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epigenetic regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression, epigenetic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ESC/E(Z) complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PHD finger protein 19
    Names
    polycomb-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418754.1 → NP_001405683.1  PHD finger protein 19 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL929068
      UniProtKB/Swiss-Prot
      Q9CXG9

    2. NM_001418755.1 → NP_001405684.1  PHD finger protein 19 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL929068

    3. NM_001418756.1 → NP_001405685.1  PHD finger protein 19 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL929068

    4. NM_028716.5 → NP_082992.1  PHD finger protein 19 isoform a

      See identical proteins and their annotated locations for NP_082992.1

      Status: VALIDATED

      Source sequence(s)
      AL929068
      Consensus CDS
      CCDS15955.1
      UniProtKB/Swiss-Prot
      Q9CXG9
      Related
      ENSMUSP00000028232.4, ENSMUST00000028232.7
      Conserved Domains (4) summary
      cd15581
      Location:195 → 246
      PHD2_PHF19; PHD finger 2 found in PHD finger protein 19 (PHF19)
      pfam14061
      Location:529 → 576
      Mtf2_C; Polycomb-like MTF2 factor 2
      pfam18104
      Location:41 → 76
      Tudor_2; Jumonji domain-containing protein 2A Tudor domain
      cl22851
      Location:96 → 148
      PHD_SF; PHD finger superfamily

    RNA

    1. NR_184813.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL929068

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      34783764..34804365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498380.2 → XP_006498443.1  PHD finger protein 19 isoform X3

      Conserved Domains (2) summary
      cd15581
      Location:43 → 94
      PHD2_PHF19; PHD finger 2 found in PHD finger protein 19 (PHF19)
      pfam14061
      Location:377 → 424
      Mtf2_C; Polycomb-like MTF2 factor 2

    2. XM_036162623.1 → XP_036018516.1  PHD finger protein 19 isoform X2

      Conserved Domains (3) summary
      cd15581
      Location:95 → 146
      PHD2_PHF19; PHD finger 2 found in PHD finger protein 19 (PHF19)
      pfam14061
      Location:429 → 476
      Mtf2_C; Polycomb-like MTF2 factor 2
      cl22851
      Location:1 → 48
      PHD_SF; PHD finger superfamily

    3. XM_036162624.1 → XP_036018517.1  PHD finger protein 19 isoform X4

      Conserved Domains (2) summary
      cd15581
      Location:24 → 75
      PHD2_PHF19; PHD finger 2 found in PHD finger protein 19 (PHF19)
      pfam14061
      Location:358 → 405
      Mtf2_C; Polycomb-like MTF2 factor 2

    4. XM_006498381.1 → XP_006498444.1  PHD finger protein 19 isoform X4

      Related
      ENSMUST00000128663.8
      Conserved Domains (2) summary
      cd15581
      Location:24 → 75
      PHD2_PHF19; PHD finger 2 found in PHD finger protein 19 (PHF19)
      pfam14061
      Location:358 → 405
      Mtf2_C; Polycomb-like MTF2 factor 2

    RNA

    1. XR_004940748.1 RNA Sequence

    2. XR_004940750.1 RNA Sequence

    3. XR_004940751.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXG9.1 GenPept UniProtKB/Swiss-Prot:Q9CXG9

    Gene LinkOut

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