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    Agpat3 1-acylglycerol-3-phosphate O-acyltransferase 3 [ Mus musculus (house mouse) ]

    Gene ID: 28169, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Agpat3provided by MGI
    Official Full Name
    1-acylglycerol-3-phosphate O-acyltransferase 3provided by MGI
    Primary source
    MGI:MGI:1336186
    See related
    Ensembl:ENSMUSG00000001211 AllianceGenome:MGI:1336186
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    lpaat3; D10Jhu12e
    Summary
    Enables lysophosphatidic acid acyltransferase activity. Predicted to act upstream of or within phospholipid biosynthetic process. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 65.3), adrenal adult (RPKM 53.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Agpat3 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (78105008..78188335, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (78269174..78352497, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27217 Neighboring gene trafficking protein particle complex 10 Neighboring gene STARR-seq mESC enhancer starr_27219 Neighboring gene predicted gene, 30122 Neighboring gene STARR-positive B cell enhancer ABC_E3894 Neighboring gene STARR-seq mESC enhancer starr_27222 Neighboring gene microRNA 7659 Neighboring gene predicted gene, 40709 Neighboring gene LSM7 homolog, U6 small nuclear RNA associated pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dietary omega-3 fatty acid does not improve male infertility caused by lysophospholipid acyltransferase 3 (LPLAT3/AGPAT3) deficiency. Nagata K, et al. Biochem Biophys Res Commun, 2023 Jun 30. PMID 37121128
    2. LPAAT3 incorporates docosahexaenoic acid into skeletal muscle cell membranes and is upregulated by PPARδ activation. Valentine WJ, et al. J Lipid Res, 2018 Feb. PMID 29284664, Free PMC Article
    3. Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells. Shindou H, et al. J Biol Chem, 2017 Jul 21. PMID 28578316, Free PMC Article
    4. Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis. Iizuka-Hishikawa Y, et al. J Biol Chem, 2017 Jul 21. PMID 28578315, Free PMC Article
    5. Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3. Koeberle A, et al. FASEB J, 2012 Jan. PMID 21968070

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A loss of function variant in AGPAT3 underlies intellectual disability and retinitis pigmentosa (IDRP) syndrome.
      Title: A loss of function variant in AGPAT3 underlies intellectual disability and retinitis pigmentosa (IDRP) syndrome.
    2. It identified lysophosphatidic acid acyltransferase (LPAAT)3 as an enzyme that was upregulated in myoblasts during in vitro differentiation and selectively incorporated DHA intophosphatidylcholine and phosphatidylethanolamine.
      Title: LPAAT3 incorporates docosahexaenoic acid into skeletal muscle cell membranes and is upregulated by PPARδ activation.
    3. Data suggest that LPAAT3 is required for producing docosahexaenoic acid- (DHA)-containing phospholipids in various tissues, such as the testes and retina; LPAAT3-knockout mice exhibit severe male infertility with abnormal sperm morphology; lack of LPAAT3 causes drastic reduction of DHA-containing phospholipids in spermatids with excess cytoplasm around the sperm head.
      Title: Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis.
    4. Data suggest that PL-DHA (docosahexaenoic acid-containing phospholipids) contribute to visual function by maintaining disc shape in photoreceptor cells; PL-DHA disappears from outer segment in LPAAT3-knockout mice; LPAAT3-knockout mice exhibit abnormalities in retinal layers, disordered disc morphology in photoreceptor cells, and impaired visual function.
      Title: Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells.
    5. The induction of LPAAT3 during germ cell development critically contributes to the accumulation of PUFAs in testicular phospholipids, thereby possibly affecting sperm cell production.
      Title: Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3.
    6. mAGPAT 1, 2, and 3 mRNA levels increased rapidly in mouse skin after acute permeability barrier disruption
      Title: Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate acyltransferases in the epidermis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophosphatidic acid acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
    Names
    1-AGP acyltransferase 3
    1-AGPAT 3
    LPAAT-gamma
    lysophosphatidic acid acyltransferase 3
    lysophosphatidic acid acyltransferase gamma
    NP_001391799.1
    NP_001391800.1
    NP_001391801.1
    NP_001391802.1
    NP_001391803.1
    NP_001391804.1
    NP_001391805.1
    NP_001391806.1
    NP_001391807.1
    NP_001391808.1
    NP_001391809.1
    NP_001391810.1
    NP_001391811.1
    NP_443747.2
    XP_006513781.1
    XP_036011691.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001404870.1 → NP_001391799.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a

      Status: VALIDATED

      Source sequence(s)
      AC160405
      UniProtKB/Swiss-Prot
      C4B4E7, Q7TT39, Q8BST2, Q9D517

    2. NM_001404871.1 → NP_001391800.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a

      Status: VALIDATED

      Source sequence(s)
      AC160405
      UniProtKB/Swiss-Prot
      C4B4E7, Q7TT39, Q8BST2, Q9D517

    3. NM_001404872.1 → NP_001391801.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a

      Status: VALIDATED

      Source sequence(s)
      AC160405
      UniProtKB/Swiss-Prot
      C4B4E7, Q7TT39, Q8BST2, Q9D517
      Related
      ENSMUSP00000101026.2, ENSMUST00000105387.8

    4. NM_001404873.1 → NP_001391802.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a

      Status: VALIDATED

      Source sequence(s)
      AC160405
      UniProtKB/Swiss-Prot
      C4B4E7, Q7TT39, Q8BST2, Q9D517

    5. NM_001404874.1 → NP_001391803.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a

      Status: VALIDATED

      Source sequence(s)
      AC160405
      UniProtKB/Swiss-Prot
      C4B4E7, Q7TT39, Q8BST2, Q9D517
      Related
      ENSMUSP00000101028.2, ENSMUST00000105389.8

    6. NM_001404875.1 → NP_001391804.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a

      Status: VALIDATED

      Source sequence(s)
      AC160405, AC160411
      UniProtKB/Swiss-Prot
      C4B4E7, Q7TT39, Q8BST2, Q9D517
      Related
      ENSMUSP00000001240.6, ENSMUST00000001240.12

    7. NM_001404876.1 → NP_001391805.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a

      Status: VALIDATED

      Source sequence(s)
      AC160405, AC160411
      UniProtKB/Swiss-Prot
      C4B4E7, Q7TT39, Q8BST2, Q9D517

    8. NM_001404877.1 → NP_001391806.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a

      Status: VALIDATED

      Source sequence(s)
      AC160405
      UniProtKB/Swiss-Prot
      C4B4E7, Q7TT39, Q8BST2, Q9D517

    9. NM_001404878.1 → NP_001391807.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform b

      Status: VALIDATED

      Source sequence(s)
      AC160405, AC160411

    10. NM_001404879.1 → NP_001391808.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform b

      Status: VALIDATED

      Source sequence(s)
      AC160405

    11. NM_001404880.1 → NP_001391809.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform b

      Status: VALIDATED

      Source sequence(s)
      AC160405

    12. NM_001404881.1 → NP_001391810.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform c

      Status: VALIDATED

      Source sequence(s)
      AC160405

    13. NM_001404882.1 → NP_001391811.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform d

      Status: VALIDATED

      Source sequence(s)
      AC160405

    14. NM_053014.4 → NP_443747.2  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a

      See identical proteins and their annotated locations for NP_443747.2

      Status: VALIDATED

      Source sequence(s)
      AC160405, AC160411
      Consensus CDS
      CCDS23963.1
      UniProtKB/Swiss-Prot
      C4B4E7, Q7TT39, Q8BST2, Q9D517
      UniProtKB/TrEMBL
      Q3TXT9
      Conserved Domains (1) summary
      PLN02380
      Location:12 → 325
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      78105008..78188335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513718.1 → XP_006513781.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      See identical proteins and their annotated locations for XP_006513781.1

      UniProtKB/Swiss-Prot
      C4B4E7, Q7TT39, Q8BST2, Q9D517
      UniProtKB/TrEMBL
      Q3TXT9
      Related
      ENSMUSP00000101029.2, ENSMUST00000105390.8
      Conserved Domains (1) summary
      PLN02380
      Location:12 → 325
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

    2. XM_036155798.1 → XP_036011691.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      UniProtKB/Swiss-Prot
      C4B4E7, Q7TT39, Q8BST2, Q9D517
      UniProtKB/TrEMBL
      Q3TXT9
      Conserved Domains (1) summary
      PLN02380
      Location:12 → 325
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D517.2 GenPept UniProtKB/Swiss-Prot:Q9D517

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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