Mob1b MOB kinase activator 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mob1bprovided by MGI
Official Full Name: MOB kinase activator 1Bprovided by MGI
Primary source: MGI:MGI:1915723
See related: Ensembl:ENSMUSG00000006262 AllianceGenome:MGI:1915723
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mobkl1a; B230364F10; 1110003E08Rik
Summary: Predicted to enable kinase binding activity and protein kinase activator activity. Predicted to be involved in hippo signaling; positive regulation of protein phosphorylation; and regulation of protein autophosphorylation. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human MOB1B (MOB kinase activator 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 5.1), CNS E11.5 (RPKM 4.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E1; 5 43.92 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (88868730..88906314)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (88720871..88758455)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1.
Title: EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1.
MOB1A and MOB1B have overlapping functions in skin homeostasis, and exert their roles as tumor suppressors by regulating downstream elements of the Hippo pathway.
Title: Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice.
Mst1/2-catalyzed MOBKL1A/B phosphorylation slows proliferation and is therefore a likely contributor to the anti-proliferative action of Mst1 in naive T cells
Title: The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.
MOBKL1A/MOBKL1B phosphorylation, by MST1 and MST2, is sufficient to inhibit proliferation through actions at several points in the cell cycle.
Title: MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

RH132869 (e-PCR)
- UniSTS:216152

NoName (e-PCR)
- UniSTS:235211

NoName (e-PCR)
- UniSTS:235212

AU015450 (e-PCR)
- UniSTS:207822

NoName (e-PCR)
- UniSTS:487894

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables kinase activator activity	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: MOB kinase activator 1B

Names: MOB1, Mps One Binder kinase activator-like 1A; mob1 homolog 1A; mps one binder kinase activator-like 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.