ING3 inhibitor of growth family member 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ING3provided by HGNC
Official Full Name: inhibitor of growth family member 3provided by HGNC
Primary source: HGNC:HGNC:14587
See related: Ensembl:ENSG00000071243 MIM:607493; AllianceGenome:HGNC:14587
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Eaf4; ING2; MEAF4; p47ING3
Summary: The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in bone marrow (RPKM 18.3), lymph node (RPKM 6.0) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q31.31

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (120950777..120977216)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (122266123..122292563)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (120590831..120617270)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ING3 inhibits the malignant progression of lung adenocarcinoma by negatively regulating ITGB4 expression to inactivate Src/FAK signaling.
Title: ING3 inhibits the malignant progression of lung adenocarcinoma by negatively regulating ITGB4 expression to inactivate Src/FAK signaling.
ING Tumour Suppressors and ING Splice Variants as Coregulators of the Androgen Receptor Signalling in Prostate Cancer.
Title: ING Tumour Suppressors and ING Splice Variants as Coregulators of the Androgen Receptor Signalling in Prostate Cancer.
Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation.
Title: Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation.
ING3 and ING4 immunoexpression and their relation to the development of benign odontogenic lesions.
Title: ING3 and ING4 immunoexpression and their relation to the development of benign odontogenic lesions.
A Novel Splice Variant of the Inhibitor of Growth 3 Lacks the Plant Homeodomain and Regulates Epithelial-Mesenchymal Transition in Prostate Cancer Cells.
Title: A Novel Splice Variant of the Inhibitor of Growth 3 Lacks the Plant Homeodomain and Regulates Epithelial-Mesenchymal Transition in Prostate Cancer Cells.
Downregulation of nuclear ING3 expression and translocalization to cytoplasm promotes tumorigenesis and progression in head and neck squamous cell carcinoma (HNSCC).
Title: Downregulation of nuclear ING3 expression and translocalization to cytoplasm promotes tumorigenesis and progression in head and neck squamous cell carcinoma (HNSCC).
Nuclear localization of ING3 is required to suppress melanoma cell migration, invasion and angiogenesis.
Title: Nuclear localization of ING3 is required to suppress melanoma cell migration, invasion and angiogenesis.
ING3 is required for ATM signaling and DNA repair in response to DNA double strand breaks.
Title: ING3 is required for ATM signaling and DNA repair in response to DNA double strand breaks.
Data show that ING3 associates with gene promoters to regulate a transcriptional network that is required for cellular proliferation. Importantly, ING3 elevated copy number and protein levels in cancer patients, particularly in treatment-resistant patients, designate ING3 as a novel marker of poor survival for cancer patients and an unsuspected oncoprotein.
Title: Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein.
results reveal the molecular mechanism of H3K4me3 selection by the ING3PHD and suggest that this interaction is important for mediating ING3 tumor suppressive activities.
Title: Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ING3-1 (e-PCR)
- UniSTS:511816

ING3 (e-PCR)
- UniSTS:503660

NoName (e-PCR)
- UniSTS:483309

RH18523 (e-PCR)
- UniSTS:57327

G20547 (e-PCR)
- UniSTS:47347

A005W09 (e-PCR)
- UniSTS:47348

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
contributes_to histone H2A acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to histone H4 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H4K12 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H4K16 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H4K5 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H4K8 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of double-strand break repair via homologous recombination	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuA4 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Swr1 complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of nucleosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of piccolo histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inhibitor of growth protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023322.1 RefSeqGene

Range

5015..31454

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_019071.3 → NP_061944.2 inhibitor of growth protein 3 isoform 1

See identical proteins and their annotated locations for NP_061944.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC004537, AF074968, AK000096, BU677936, BU684039

Consensus CDS

CCDS5778.1

UniProtKB/Swiss-Prot

A8K790, O60394, Q567P3, Q6GMT3, Q7Z762, Q969G0, Q96DT4, Q9HC99, Q9NXR8, Q9P081

UniProtKB/TrEMBL

Q5GRH6

Related

ENSP00000320566.5, ENST00000315870.10

Conserved Domains (3) summary

COG5034
Location:4 → 410

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15585
Location:362 → 406

PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins

pfam12998
Location:3 → 102

ING; Inhibitor of growth proteins N-terminal histone-binding
NM_198267.2 → NP_938008.1 inhibitor of growth protein 3 isoform 3

See identical proteins and their annotated locations for NP_938008.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses a different segment in its 3' coding region and UTR, compared to variant 1, with a resulting frameshift. The predicted isoform (3) has a distinct and shorter C-terminus, as compared to isoform 1. This transcript is supported by several ESTs, but the predicted ORF has not yet been experimentally confirmed.

Source sequence(s)

AK000096, BC009777, CA442734

Consensus CDS

CCDS35497.1

UniProtKB/TrEMBL

A0A0C4DG38

Related

ENSP00000341697.5, ENST00000339121.9

Conserved Domains (1) summary

pfam12998
Location:3 → 89

ING; Inhibitor of growth proteins N-terminal histone-binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

120950777..120977216

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047420535.1 → XP_047276491.1 inhibitor of growth protein 3 isoform X1

Related

ENSP00000410406.1, ENST00000427726.5
XM_017012369.3 → XP_016867858.1 inhibitor of growth protein 3 isoform X2

UniProtKB/TrEMBL

A0A0C4DG38, B7ZKQ7

Related

ENSP00000395719.1, ENST00000445699.5

Conserved Domains (1) summary

pfam12998
Location:3 → 89

ING; Inhibitor of growth proteins N-terminal histone-binding

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

122266123..122292563

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054358511.1 → XP_054214486.1 inhibitor of growth protein 3 isoform X1
XM_054358512.1 → XP_054214487.1 inhibitor of growth protein 3 isoform X2

UniProtKB/TrEMBL

B7ZKQ7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_198266.1: Suppressed sequence

Description

NM_198266.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.