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    Cops2 COP9 signalosome subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 12848, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Cops2provided by MGI
    Official Full Name
    COP9 signalosome subunit 2provided by MGI
    Primary source
    MGI:MGI:1330276
    See related
    Ensembl:ENSMUSG00000027206 AllianceGenome:MGI:1330276
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Csn2; Sgn2; Trip15; TRIP-15
    Summary
    Enables transcription corepressor activity. Acts upstream of or within inner cell mass cell proliferation; negative regulation of transcription, DNA-templated; and skeletal muscle cell differentiation. Located in nucleus. Part of COP9 signalosome. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human COPS2 (COP9 signalosome subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in placenta adult (RPKM 25.1), CNS E11.5 (RPKM 23.9) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 F1; 2 61.76 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (125672222..125701002, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (125830302..125859082, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene SHC (Src homology 2 domain containing) family, member 4 Neighboring gene STARR-seq mESC enhancer starr_05593 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:125550365-125550474 Neighboring gene predicted gene, 35231 Neighboring gene STARR-positive B cell enhancer ABC_E11155 Neighboring gene SECIS binding protein 2-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:125602741-125602942 Neighboring gene STARR-positive B cell enhancer ABC_E5976 Neighboring gene STARR-positive B cell enhancer ABC_E7857 Neighboring gene STARR-positive B cell enhancer ABC_E11156 Neighboring gene galactokinase 2 Neighboring gene family with sequence similarity 227, member B Neighboring gene fibroblast growth factor 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN. Alves CRR, et al. Mol Metab, 2020 Sep. PMID 32408015, Free PMC Article
    2. Cops2 promotes pluripotency maintenance by Stabilizing Nanog Protein and Repressing Transcription. Zhang W, et al. Sci Rep, 2016 May 26. PMID 27226076, Free PMC Article
    3. Implication of Trip15/CSN2 in early stage of neuronal differentiation of P19 embryonal carcinoma cells. Akiyama H, et al. Brain Res Dev Brain Res, 2003 Jan 10. PMID 12524175
    4. COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence. Menon S, et al. Nat Immunol, 2007 Nov. PMID 17906629
    5. Alien/CSN2 gene expression is regulated by thyroid hormone in rat brain. Tenbaum SP, et al. Dev Biol, 2003 Feb 1. PMID 12606288

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN.
      Title: Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN.
    2. Cops2, but not the whole COP9 signalosome, is essential for pluripotency maintenance in mouse embryonic stem cells. Down-regulation of Cops2 reduces expression of pluripotency genes, slows proliferation rate, arrests G2/M cell cycle, and compromises ESC embryoid differentiation. Cops2 binds to Nanog protein and prevents degradation. Cops2 functions as transcriptional corepressor to facilitate pluripotency maintenance.
      Title: Cops2 promotes pluripotency maintenance by Stabilizing Nanog Protein and Repressing Transcription.
    3. these data indicate that Alien/ESET complex is involved in TRbeta1-mediated transcription repression of E2F1 and provide a molecular basis of thyroid hormone-induced repression of proliferation.
      Title: Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation.
    4. Disruption of Cops2 causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death.
      Title: Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death.
    5. Expressed at an early stage of neuronal differentiation of P19 embryonal carcinoma cells.
      Title: Implication of Trip15/CSN2 in early stage of neuronal differentiation of P19 embryonal carcinoma cells.
    6. Nif3l1 participates in neural differentiation of P19 cells through cooperation with Trip15/CSN2.
      Title: The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within inner cell mass cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deneddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deneddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within trophectodermal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    COP9 signalosome complex subunit 2
    Names
    COP9 (constitutive photomorphogenic) homolog, subunit 2
    JAB1-containing signalosome subunit 2
    TR-interacting protein 15
    alien homolog
    alien-like
    thyroid receptor-interacting protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285507.1 → NP_001272436.1  COP9 signalosome complex subunit 2 isoform a

      See identical proteins and their annotated locations for NP_001272436.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK037757, AL844580, BQ031086, CJ052709
      Consensus CDS
      CCDS71133.1
      UniProtKB/TrEMBL
      Q3UK65, Q3V3N6
      Related
      ENSMUSP00000106090.2, ENSMUST00000110463.8
      Conserved Domains (2) summary
      COG5159
      Location:40 → 441
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:316 → 420
      PCI; PCI domain

    2. NM_001285512.1 → NP_001272441.1  COP9 signalosome complex subunit 2 isoform c

      See identical proteins and their annotated locations for NP_001272441.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (c) is shorter than isoform a. Variants 3 and 4 encode the same protein.
      Source sequence(s)
      AK084421, AK132776, BQ031086, CJ052709
      UniProtKB/Swiss-Prot
      P61202
      Conserved Domains (2) summary
      COG5159
      Location:1 → 310
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:185 → 289
      PCI; PCI domain

    3. NM_001285513.1 → NP_001272442.1  COP9 signalosome complex subunit 2 isoform c

      See identical proteins and their annotated locations for NP_001272442.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon compared to variant 1. The encoded isoform (c) is shorter than isoform a. Variants 3 and 4 encode the same protein.
      Source sequence(s)
      AL844580
      Conserved Domains (2) summary
      COG5159
      Location:1 → 310
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:185 → 289
      PCI; PCI domain

    4. NM_009939.3 → NP_034069.2  COP9 signalosome complex subunit 2 isoform b

      See identical proteins and their annotated locations for NP_034069.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
      Source sequence(s)
      AK084421, BQ031086, CJ052709
      Consensus CDS
      CCDS16679.1
      UniProtKB/Swiss-Prot
      P61202, Q3V1W6, Q8R5B0, Q9CWU1
      UniProtKB/TrEMBL
      Q3UK65
      Related
      ENSMUSP00000028635.6, ENSMUST00000028635.6
      Conserved Domains (2) summary
      COG5159
      Location:40 → 434
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:309 → 413
      PCI; PCI domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      125672222..125701002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61202.1 GenPept UniProtKB/Swiss-Prot:P61202

    Gene LinkOut

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