Ctla2a cytotoxic T lymphocyte-associated protein 2 alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctla2aprovided by MGI
Official Full Name: cytotoxic T lymphocyte-associated protein 2 alphaprovided by MGI
Primary source: MGI:MGI:88554
See related: Ensembl:ENSMUSG00000044258 AllianceGenome:MGI:88554
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ctla-2a
Summary: Predicted to enable cysteine-type endopeptidase activity. Acts upstream of or within negative regulation of inflammatory response; negative regulation of protein processing; and regulation of regulatory T cell differentiation. Located in dendrite. Is expressed in several structures, including blood; cerebral cortex; esophagus; genitourinary system; and lung. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 179.4) and lung adult (RPKM 12.9) See more
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Genomic context

Location:: 13 B2; 13 32.56 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (61081969..61084439, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (60934155..60936625, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CTLA-2 secretion is induced by dendritic cells to enhance regulatory T cell conversion after administration of cholera toxin and cAMP
Title: Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion.
that the fine equilibrium between synthesis and secretion of cathespin L and CTLA-2alpha is part of the brain processes to maintain normal growth and development
Title: Cathepsin L coexists with Cytotoxic T-lymphocyte Antigen-2 alpha in distinct regions of the mouse brain.
Double immunofluorescence analysis showed that CTLA-2alpha was co-localized with cathepsin L, cathepsin C, and TINAGL1 in placenta.
Title: Identification and characterization of the interactive proteins with cytotoxic T-lymphocyte antigen-2α.
cAMP increases CTLA-2alpha expression in murine lymphoma and cardiac fibroblasts, and this increase in CTLA-2alpha contributes to cAMP/PKA-promoted apoptosis by mechanisms that are independent of the ability of CTLA-2alpha to inhibit cathepsin L.
Title: Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA.

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General gene information

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Markers

px-31f3 (e-PCR)
- UniSTS:257585

UniSTS:495977 (e-PCR)
- UniSTS:495977

Avpr1b (e-PCR), detects polymorphism
- UniSTS:495977

Ctla2a (e-PCR), detects polymorphism
- UniSTS:141441

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of regulatory T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein CTLA-2-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145799.1 → NP_001139271.1 protein CTLA-2-alpha isoform b

See identical proteins and their annotated locations for NP_001139271.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AA451288, AK018801, AK132290

UniProtKB/TrEMBL

A0A286YDF0

Conserved Domains (1) summary

smart00848
Location:16 → 74

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
NM_007796.2 → NP_031822.2 protein CTLA-2-alpha isoform a precursor

See identical proteins and their annotated locations for NP_031822.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AK132290, AK167433, BB574774

Consensus CDS

CCDS49290.1

UniProtKB/Swiss-Prot

P12399, Q91V07

UniProtKB/TrEMBL

A0A286YDF0

Related

ENSMUSP00000021880.10, ENSMUST00000021880.10

Conserved Domains (1) summary

smart00848
Location:40 → 98

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)