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    Zfp346 zinc finger protein 346 [ Mus musculus (house mouse) ]

    Gene ID: 26919, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp346provided by MGI
    Official Full Name
    zinc finger protein 346provided by MGI
    Primary source
    MGI:MGI:1349417
    See related
    Ensembl:ENSMUSG00000021481 AllianceGenome:MGI:1349417
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jaz; Znf346
    Summary
    Enables double-stranded RNA binding activity. Acts upstream of or within positive regulation of apoptotic process. Located in nucleolus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human ZNF346 (zinc finger protein 346). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 8.7), CNS E18 (RPKM 7.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 B1; 13 29.8 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55253079..55282884)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55105271..55135071)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene unc-5 netrin receptor A Neighboring gene hexokinase 3 Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene STARR-seq mESC enhancer starr_34599 Neighboring gene STARR-positive B cell enhancer ABC_E1877 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr13:55226322-55226622 Neighboring gene predicted gene, 46415 Neighboring gene fibroblast growth factor receptor 4 Neighboring gene STARR-positive B cell enhancer ABC_E5399 Neighboring gene STARR-seq mESC enhancer starr_34607 Neighboring gene STARR-seq mESC enhancer starr_34609 Neighboring gene nuclear receptor-binding SET-domain protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. JAZ mediates G1 cell-cycle arrest and apoptosis by positively regulating p53 transcriptional activity. Yang M, et al. Blood, 2006 Dec 15. PMID 16931621, Free PMC Article
    2. JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization. Yang M, et al. J Biol Chem, 1999 Sep 24. PMID 10488071
    3. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636
    4. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
    5. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. JAZ is a novel negative regulator of cell growth by positively regulating p53.
      Title: JAZ mediates G1 cell-cycle arrest and apoptosis by positively regulating p53 transcriptional activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 346
    Names
    just another zinc finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378934.1 → NP_001365863.1  zinc finger protein 346 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC123709, AC154610
      UniProtKB/TrEMBL
      E9Q7N8
      Related
      ENSMUSP00000125078.2, ENSMUST00000159278.8
      Conserved Domains (2) summary
      smart00451
      Location:198 → 232
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:203 → 225
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001378935.1 → NP_001365864.1  zinc finger protein 346 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123709, AC154610
      UniProtKB/TrEMBL
      F7CTY2
      Related
      ENSMUSP00000125204.2, ENSMUST00000161077.2
      Conserved Domains (2) summary
      smart00451
      Location:198 → 232
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:75 → 97
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_012017.2 → NP_036147.1  zinc finger protein 346 isoform 1

      See identical proteins and their annotated locations for NP_036147.1

      Status: VALIDATED

      Source sequence(s)
      AK033852, AK084710, BB612150, BU706820, CV562260, CX564256
      Consensus CDS
      CCDS26539.1
      UniProtKB/Swiss-Prot
      Q9R0B7
      UniProtKB/TrEMBL
      E9Q7N8
      Related
      ENSMUSP00000021937.6, ENSMUST00000021937.12
      Conserved Domains (2) summary
      smart00451
      Location:182 → 216
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:136 → 158
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. NR_166188.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC123709, AC154610

    2. NR_166189.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC123709, AC154610

    3. NR_166190.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC123709, AC154610

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      55253079..55282884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247283.2 → XP_030103143.1  zinc finger protein 346 isoform X1

      UniProtKB/TrEMBL
      F7CTY2
      Conserved Domains (2) summary
      smart00451
      Location:194 → 228
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:148 → 170
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0B7.1 GenPept UniProtKB/Swiss-Prot:Q9R0B7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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