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    Pvalb parvalbumin [ Mus musculus (house mouse) ]

    Gene ID: 19293, updated on 5-Apr-2024

    Summary

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    Official Symbol
    Pvalbprovided by MGI
    Official Full Name
    parvalbuminprovided by MGI
    Primary source
    MGI:MGI:97821
    See related
    Ensembl:ENSMUSG00000005716 AllianceGenome:MGI:97821
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PV; Pva; Parv
    Summary
    Predicted to enable calcium ion binding activity and identical protein binding activity. Involved in excitatory chemical synaptic transmission; gene expression; and inhibitory chemical synaptic transmission. Located in axon and cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Orthologous to human PVALB (parvalbumin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 192.6), mammary gland adult (RPKM 147.4) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pvalb in Genome Data Viewer
    Location:
    15 E1; 15 36.93 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78075312..78090600, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78191112..78206400, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, gamma subunit 2 Neighboring gene RIKEN cDNA A730060N03 gene Neighboring gene STARR-positive B cell enhancer mm9_chr15:77950201-77950501 Neighboring gene STARR-positive B cell enhancer ABC_E4137 Neighboring gene STARR-positive B cell enhancer ABC_E4138 Neighboring gene intraflagellar transport 27 Neighboring gene STARR-seq mESC enhancer starr_39140 Neighboring gene STARR-seq mESC enhancer starr_39141 Neighboring gene STARR-positive B cell enhancer ABC_E2443 Neighboring gene STARR-positive B cell enhancer ABC_E9914 Neighboring gene neutrophil cytosolic factor 4 Neighboring gene microRNA 7676-1 Neighboring gene colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fast-Spiking Interneurons of the Premotor Cortex Contribute to Initiation and Execution of Spontaneous Actions. Giordano N, et al. J Neurosci, 2023 Jun 7. PMID 37197980, Free PMC Article
    2. A shift in the mechanisms controlling hippocampal engram formation during brain maturation. Ramsaran AI, et al. Science, 2023 May 5. PMID 37141366
    3. HCN channels at the cell soma ensure the rapid electrical reactivity of fast-spiking interneurons in human neocortex. Szegedi V, et al. PLoS Biol, 2023 Feb. PMID 36745683, Free PMC Article
    4. Optogenetic Low-Frequency Stimulation of Principal Neurons, but Not Parvalbumin-Positive Interneurons, Prevents Generation of Ictal Discharges in Rodent Entorhinal Cortex in an In Vitro 4-Aminopyridine Model. Proskurina EY, et al. Int J Mol Sci, 2022 Dec 22. PMID 36613660, Free PMC Article
    5. Reduced inhibitory and excitatory input onto parvalbumin interneurons mediated by perineuronal net might contribute to cognitive impairments in a mouse model of sepsis-associated encephalopathy. Zhang L, et al. Neuropharmacology, 2023 Mar 1. PMID 36543316

    See all (1393) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Parvalbumin and Somatostatin: Biomarkers for Two Parallel Tectothalamic Pathways in the Auditory Midbrain.
      Title: Parvalbumin and Somatostatin: Biomarkers for Two Parallel Tectothalamic Pathways in the Auditory Midbrain.
    2. Parvalbumin interneurons dysfunction is potentially associated with FalphaMNs decrease and NRG1-ErbB4 signaling inhibition in spinal cord in amyotrophic lateral sclerosis.
      Title: Parvalbumin interneurons dysfunction is potentially associated with FαMNs decrease and NRG1-ErbB4 signaling inhibition in spinal cord in amyotrophic lateral sclerosis.
    3. Prefrontal and Hippocampal Parvalbumin Interneurons in Animal Models for Schizophrenia: A Systematic Review and Meta-analysis.
      Title: Prefrontal and Hippocampal Parvalbumin Interneurons in Animal Models for Schizophrenia: A Systematic Review and Meta-analysis.
    4. Velocity of conduction between columns and layers in barrel cortex reported by parvalbumin interneurons.
      Title: Velocity of conduction between columns and layers in barrel cortex reported by parvalbumin interneurons.
    5. Deletions of Cacna2d3 in parvalbumin-expressing neurons leads to autistic-like phenotypes in mice.
      Title: Deletions of Cacna2d3 in parvalbumin-expressing neurons leads to autistic-like phenotypes in mice.
    6. Circadian time- and sleep-dependent modulation of cortical parvalbumin-positive inhibitory neurons.
      Title: Circadian time- and sleep-dependent modulation of cortical parvalbumin-positive inhibitory neurons.
    7. Reduced inhibitory and excitatory input onto parvalbumin interneurons mediated by perineuronal net might contribute to cognitive impairments in a mouse model of sepsis-associated encephalopathy.
      Title: Reduced inhibitory and excitatory input onto parvalbumin interneurons mediated by perineuronal net might contribute to cognitive impairments in a mouse model of sepsis-associated encephalopathy.
    8. NMDA receptor hypofunction underlies deficits in parvalbumin interneurons and social behavior in neuroligin 3 R451C knockin mice.
      Title: NMDA receptor hypofunction underlies deficits in parvalbumin interneurons and social behavior in neuroligin 3 R451C knockin mice.
    9. Genetic targeting of adult Renshaw cells using a Calbindin 1 destabilized Cre allele for intersection with Parvalbumin or Engrailed1.
      Title: Genetic targeting of adult Renshaw cells using a Calbindin 1 destabilized Cre allele for intersection with Parvalbumin or Engrailed1.
    10. Postnatal Sox6 Regulates Synaptic Function of Cortical Parvalbumin-Expressing Neurons.
      Title: Postnatal Sox6 Regulates Synaptic Function of Cortical Parvalbumin-Expressing Neurons.
    Submit: New GeneRIF Correction See all GeneRIFs (87)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (16)  1 citation
    • Endonuclease-mediated (5) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in excitatory chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inhibitory chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cuticular plate ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stereocilium ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    parvalbumin alpha

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330686.1 → NP_001317615.1  parvalbumin alpha

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI645659, AK131986, DV051867
      Consensus CDS
      CCDS27609.1
      UniProtKB/Swiss-Prot
      P32848
      UniProtKB/TrEMBL
      Q545M7
      Related
      ENSMUSP00000005860.10, ENSMUST00000005860.16
      Conserved Domains (1) summary
      cd16254
      Location:9 → 109
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    2. NM_013645.4 → NP_038673.2  parvalbumin alpha

      See identical proteins and their annotated locations for NP_038673.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA467036, AI645659, AL589692, CK622340, DV051867
      Consensus CDS
      CCDS27609.1
      UniProtKB/Swiss-Prot
      P32848
      UniProtKB/TrEMBL
      Q545M7
      Related
      ENSMUSP00000112598.2, ENSMUST00000120592.2
      Conserved Domains (1) summary
      cd16254
      Location:9 → 109
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      78075312..78090600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32848.3 GenPept UniProtKB/Swiss-Prot:P32848

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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