Oxsr1 oxidative-stress responsive 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oxsr1provided by MGI
Official Full Name: oxidative-stress responsive 1provided by MGI
Primary source: MGI:MGI:1917378
See related: Ensembl:ENSMUSG00000036737 AllianceGenome:MGI:1917378
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Osr1; mKIAA1101; 2210022N24Rik; 2810422B09Rik
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including cellular hypotonic response; chemokine (C-C motif) ligand 21 signaling pathway; and positive regulation of T cell chemotaxis. Predicted to be located in cytosol. Is expressed in loop of Henle distal straight tubule and metanephros. Orthologous to human OXSR1 (oxidative stress responsive kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 9.9), CNS E11.5 (RPKM 9.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F3; 9 71.33 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (119067498..119154475, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (119238432..119322684, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

circROCK1 Promotes septic myocardial injury through regulating miR-96-5p/OXSR1 axis.
Title: circROCK1 Promotes septic myocardial injury through regulating miR-96-5p/OXSR1 axis.
SPAK and OSR1 dependent down-regulation of murine renal outer medullary K channel ROMK1.
Title: SPAK and OSR1 dependent down-regulation of murine renal outer medullary K channel ROMK1.
Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.
Title: Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.
WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade.
Title: WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade.
Regulation of the Na+-Cl- cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone.
Title: Regulation of the Na+-Cl- cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone.
Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
Title: Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
Regulation of erythrocyte Na(+)/K(+)/2Cl(-) cotransport by an oxygen-switched kinase cascade.
Title: Regulation of erythrocyte Na(+)/K(+)/2Cl(-) cotransport by an oxygen-switched kinase cascade.
increased phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter in obesity and identifies a new role for AMP-activated protein kinase in regulating the activity of oxidative stress responsive 1 kinase-related proline-alanine-rich protein kinase
Title: Novel mechanisms of Na+ retention in obesity: phosphorylation of NKCC2 and regulation of SPAK/OSR1 by AMPK.
OSR1 is expressed in intestine and partial WNK insensitivity of OSR1 increases intestinal Na( )/H( ) exchanger activity and colonic epithelium Na( ) channel activity
Title: OSR1-sensitive small intestinal Na+ transport.
Data indicate that SPAK and OSR1 function interdependently in the distal convoluted tubule (DCT) to positively regulate thiazide-sensitive sodium-chloride cotransporter, NCC.
Title: SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW209236 (e-PCR)
- UniSTS:179991

AI462649 (e-PCR)
- UniSTS:179992

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell volume homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular hyperosmotic response	ISO Inferred from Sequence Orthology more info
involved_in cellular hypotonic response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to chemokine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to chemokine	ISO Inferred from Sequence Orthology more info
involved_in chemokine (C-C motif) ligand 21 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemokine (C-X-C motif) ligand 12 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of potassium ion transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of potassium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of potassium ion transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in osmosensory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-threonine phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in renal sodium ion absorption	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase OSR1

Names: oxidative stress-responsive 1 protein

NP_001346511.1

EC 2.7.11.1

NP_598746.2

EC 2.7.11.1

XP_030099862.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359582.1 → NP_001346511.1 serine/threonine-protein kinase OSR1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same protein.

Source sequence(s)

AC128702

Consensus CDS

CCDS57714.1

UniProtKB/Swiss-Prot

Q6P9R2, Q8BVZ9, Q8C0B9

UniProtKB/TrEMBL

Q6ZPX7

Conserved Domains (1) summary

cd06610
Location:15 → 291

STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
NM_133985.2 → NP_598746.2 serine/threonine-protein kinase OSR1

See identical proteins and their annotated locations for NP_598746.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the functional protein.

Source sequence(s)

AC128702, BC060645

Consensus CDS

CCDS57714.1

UniProtKB/Swiss-Prot

Q6P9R2, Q8BVZ9, Q8C0B9

UniProtKB/TrEMBL

Q6ZPX7

Related

ENSMUSP00000042155.5, ENSMUST00000040853.11

Conserved Domains (1) summary

cd06610
Location:15 → 291

STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

RNA

NR_045693.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC128702

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

119067498..119154475 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244002.2 → XP_030099862.1 serine/threonine-protein kinase OSR1 isoform X1

Conserved Domains (2) summary

pfam12202
Location:242 → 299

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

cl21453
Location:1 → 99

PKc_like; Protein Kinases, catalytic domain