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    Tekt1 tektin 1 [ Mus musculus (house mouse) ]

    Gene ID: 21689, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tekt1provided by MGI
    Official Full Name
    tektin 1provided by MGI
    Primary source
    MGI:MGI:1333819
    See related
    Ensembl:ENSMUSG00000020799 AllianceGenome:MGI:1333819
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MT14
    Summary
    Predicted to be involved in cilium assembly and cilium movement involved in cell motility. Located in microtubule cytoskeleton. Is expressed in several structures, including brain; lung; sensory organ; and testis. Orthologous to human TEKT1 (tektin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 66.9) and lung adult (RPKM 2.4) See more
    Orthologs
    human all
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    Genomic context

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    See Tekt1 in Genome Data Viewer
    Location:
    11 B4; 11 44.03 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72235543..72253268, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72344717..72362442, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene XIAP associated factor 1 Neighboring gene F-box protein 39 Neighboring gene predicted gene, 51867 Neighboring gene predicted gene, 34317 Neighboring gene microRNA 6338 Neighboring gene smoothelin-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The spatial and temporal expression of Tekt1, a mouse tektin C homologue, during spermatogenesis suggest that it is involved in the development of the sperm tail basal body and axoneme. Larsson M, et al. Eur J Cell Biol, 2000 Oct. PMID 11089920
    2. Localization of Tektin 1 at both acrosome and flagella of mouse and bull spermatozoa. Oiki S, et al. Zoolog Sci, 2014 Feb. PMID 24521320
    3. Cloning of canine cDNA encoding tektin. Zhiyong MA, et al. J Vet Med Sci, 2000 Sep. PMID 11039601
    4. Study of Tnp1, Tekt1, and Plzf Genes Expression During an in vitro Three-Dimensional Neonatal Male Mice Testis Culture. Alrahel A, et al. Iran Biomed J, 2018 Jul. PMID 29397043, Free PMC Article
    5. Cep57 protein is required for cytokinesis by facilitating central spindle microtubule organization. He R, et al. J Biol Chem, 2013 May 17. PMID 23569207, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tnp1, Tekt1, and Plzf have essential roles in spermatogenesis and can be expressed during organ culture of testis; with this system, genes can be induced only at the molecular level and not beyond meiosis.
      Title: Study of Tnp1, Tekt1, and Plzf Genes Expression During an in vitro Three-Dimensional Neonatal Male Mice Testis Culture.
    2. These observations suggest another potential role for TEKT1 as a cytoskeletal element in the sperm head, or as a molecule involved in acrosome-related phenomena, such as acrosome reaction.
      Title: Localization of Tektin 1 at both acrosome and flagella of mouse and bull spermatozoa.
    3. Tekt1 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
      Title: Tissue expression patterns identify mouse cilia genes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tektin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282006.1 → NP_001268935.1  tektin-1

      See identical proteins and their annotated locations for NP_001268935.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK005801, AV279795
      Consensus CDS
      CCDS36215.1
      UniProtKB/Swiss-Prot
      Q9DAJ2
      UniProtKB/TrEMBL
      Q5NBU4, Q9Z285
      Related
      ENSMUSP00000021155.4, ENSMUST00000021155.4
      Conserved Domains (1) summary
      pfam03148
      Location:16 → 395
      Tektin; Tektin family

    2. NM_001282007.1 → NP_001268936.1  tektin-1

      See identical proteins and their annotated locations for NP_001268936.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AV279795, BC050967
      Consensus CDS
      CCDS36215.1
      UniProtKB/Swiss-Prot
      Q9DAJ2
      UniProtKB/TrEMBL
      Q5NBU4, Q9Z285
      Related
      ENSMUSP00000104142.2, ENSMUST00000108502.8
      Conserved Domains (1) summary
      pfam03148
      Location:16 → 395
      Tektin; Tektin family

    3. NM_011569.3 → NP_035699.2  tektin-1

      See identical proteins and their annotated locations for NP_035699.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AV279795, BB572578, BC098181, BY085053
      Consensus CDS
      CCDS36215.1
      UniProtKB/Swiss-Prot
      Q9DAJ2
      UniProtKB/TrEMBL
      Q5NBU4, Q9Z285
      Related
      ENSMUSP00000104143.3, ENSMUST00000108503.9
      Conserved Domains (1) summary
      pfam03148
      Location:16 → 395
      Tektin; Tektin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      72235543..72253268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532933.3 → XP_006532996.1  tektin-1 isoform X1

      UniProtKB/TrEMBL
      Q9Z285
      Conserved Domains (1) summary
      pfam03148
      Location:19 → 349
      Tektin; Tektin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAJ2.1 GenPept UniProtKB/Swiss-Prot:Q9DAJ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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