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    Baiap2l2 BAI1-associated protein 2-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 207495, updated on 7-May-2024

    Summary

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    Official Symbol
    Baiap2l2provided by MGI
    Official Full Name
    BAI1-associated protein 2-like 2provided by MGI
    Primary source
    MGI:MGI:2652819
    See related
    Ensembl:ENSMUSG00000018126 AllianceGenome:MGI:2652819
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables identical protein binding activity and phospholipid binding activity. Involved in membrane organization. Predicted to be located in cell-cell contact zone and vesicle membrane. Predicted to be part of clathrin complex. Predicted to be active in cytosol and nucleoplasm. Orthologous to human BAIAP2L2 (BAR/IMD domain containing adaptor protein 2 like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in duodenum adult (RPKM 107.8), small intestine adult (RPKM 66.3) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Baiap2l2 in Genome Data Viewer
    Location:
    15 E1; 15 37.7 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79142395..79169756, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79258195..79285556, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 8 Neighboring gene lectin, galactose binding, soluble 1, pseudogene 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:79110794-79110903 Neighboring gene phospholipase A2, group VI Neighboring gene predicted gene, 41358 Neighboring gene predicted gene 20420

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BAIAP2L2 is required for the maintenance of mechanotransducing stereocilia of cochlear hair cells. Yan K, et al. J Cell Physiol, 2022 Jan. PMID 34346063
    2. Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness. Carlton AJ, et al. J Physiol, 2021 Feb. PMID 33151556, Free PMC Article
    3. Ca(2+) entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips. Halford J, et al. Mol Biol Cell, 2022 Apr 1. PMID 35044843, Free PMC Article
    4. Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures. Pykäläinen A, et al. Nat Struct Mol Biol, 2011 Jul 10. PMID 21743456, Free PMC Article
    5. HNF1β-associated cyst development and electrolyte disturbances are not explained by BAIAP2L2 expression. Tholen LE, et al. FASEB J, 2023 Jan. PMID 36520027

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HNF1beta-associated cyst development and electrolyte disturbances are not explained by BAIAP2L2 expression.
      Title: HNF1β-associated cyst development and electrolyte disturbances are not explained by BAIAP2L2 expression.
    2. Ca(2+) entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips.
      Title: Ca(2+) entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips.
    3. BAIAP2L2 is required for the maintenance of mechanotransducing stereocilia of cochlear hair cells.
      Title: BAIAP2L2 is required for the maintenance of mechanotransducing stereocilia of cochlear hair cells.
    4. Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness.
      Title: Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness.
    5. Pinkbar, is specifically expressed in intestinal epithelial cells, where it localizes to Rab13-positive vesicles and to the plasma membrane at intercellular junctions.
      Title: Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56984

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin crosslink formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell contact zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of clathrin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
    Names
    BAI1-associated protein 2-like protein 2
    pinkbar
    planar intestinal- and kidney-specific BAR domain protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177580.3 → NP_808248.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2

      See identical proteins and their annotated locations for NP_808248.1

      Status: VALIDATED

      Source sequence(s)
      AL591913
      Consensus CDS
      CCDS37140.1
      UniProtKB/Swiss-Prot
      Q3UP58, Q80Y61
      Related
      ENSMUSP00000127816.2, ENSMUST00000165408.8
      Conserved Domains (2) summary
      cd07644
      Location:6 → 220
      I-BAR_IMD_BAIAP2L2; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
      cd11914
      Location:327 → 385
      SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      79142395..79169756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520679.2 → XP_006520742.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X1

      Conserved Domains (2) summary
      cd07644
      Location:6 → 220
      I-BAR_IMD_BAIAP2L2; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
      cd11914
      Location:327 → 385
      SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2

    2. XM_006520682.4 → XP_006520745.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X3

      See identical proteins and their annotated locations for XP_006520745.1

      Conserved Domains (1) summary
      cd11914
      Location:120 → 178
      SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2

    3. XM_006520680.5 → XP_006520743.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X3

      See identical proteins and their annotated locations for XP_006520743.1

      Conserved Domains (1) summary
      cd11914
      Location:120 → 178
      SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2

    4. XM_030248434.1 → XP_030104294.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X2

      Conserved Domains (2) summary
      PRK12323
      Location:116 → 231
      PRK12323; DNA polymerase III subunit gamma/tau
      cl17036
      Location:251 → 309
      SH3; Src Homology 3 domain superfamily

    5. XM_006520681.3 → XP_006520744.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X3

      See identical proteins and their annotated locations for XP_006520744.1

      Conserved Domains (1) summary
      cd11914
      Location:120 → 178
      SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80Y61.1 GenPept UniProtKB/Swiss-Prot:Q80Y61

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