repo reversed polarity [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: repoprovided by FlyBase
Official Full Name: reversed polarityprovided by FlyBase
Primary source: FLYBASE:FBgn0011701
Locus tag: Dmel_CG31240
See related: AllianceGenome:FB:FBgn0011701
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 3702; AbRK2; CG31240; CG8045(CT24072); CT24072; Dmel\CG31240; l(3)03702; Repo; REPO; rk2; RK2
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of hemocyte differentiation; nervous system development; and regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; extended germ band embryo; glial cell; imaginal disc; and presumptive embryonic/larval nervous system. Human ortholog(s) of this gene implicated in X-linked lissencephaly 2; corpus callosum agenesis-abnormal genitalia syndrome; developmental and epileptic encephalopathy 1; and intellectual disability (multiple). Orthologous to human ARX (aristaless related homeobox). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 90F9-90F10; 3-62 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18236192..18239602)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14061914..14065324)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Repo expression is continuously required in adult glia to transcriptionally regulate the highly conserved function of neurotransmitter recycling in both males and females.
Title: Transcriptional Regulation of the Glutamate/GABA/Glutamine Cycle in Adult Glia Controls Motor Activity and Seizures in Drosophila.
Repo expression inhibits the expression of hemocyte-specific genes in the nervous system
Title: The Repo Homeodomain Transcription Factor Suppresses Hematopoiesis in Drosophila and Preserves the Glial Fate.
REPO directly regulates DRPR expression. gcm and repo have a critical role in controlling glial phagocytic function through regulation of SIMU and DRPR specific expression.
Title: Developmental regulation of glial cell phagocytic function during Drosophila embryogenesis.
we characterized three cis-regulatory elements
Title: Characterization of cis-regulatory elements controlling repo transcription in Drosophila melanogaster.
These results indicate that cas could be directly suppressed by Repo.
Title: Ectopic Repo suppresses expression of castor gene in Drosophila central nervous system.
novel role for the dVDUP1 tumor suppressor during nervous system development as a regulatory target for REPO during gliogenesis
Title: The tumor suppressor, vitamin D3 up-regulated protein 1 (VDUP1), functions downstream of REPO during Drosophila gliogenesis.
Gcm acts synergistically with other factors to control repo transcription in glial cells
Title: Transcriptional regulation of the Drosophila glial gene repo.
REPO plays a key role in both glial development and diversification.
Title: Drosophila homeodomain protein REPO controls glial differentiation by cooperating with ETS and BTB transcription factors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in glial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of hemocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of phagocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed