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    Idh3a Isocitrate dehydrogenase 3a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32940, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Idh3aprovided by FlyBase
    Official Full Name
    Isocitrate dehydrogenase 3aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027291
    Locus tag
    Dmel_CG12233
    See related
    AllianceGenome:FB:FBgn0027291
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12233; dIDH3a; Dmel\CG12233; idh3a; IDH3A; l (1) G0156; l(1)G0156; lethal (1) G0156
    Summary
    Predicted to enable isocitrate dehydrogenase (NAD+) activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including adult heart; embryonic/larval muscle system; extended germ band embryo; gut section; and visceral muscle primordium. Used to study neuromuscular junction disease. Human ortholog(s) of this gene implicated in retinitis pigmentosa 90. Orthologous to human IDH3A (isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Idh3a in Genome Data Viewer
    Location:
    18C8-18C8; 1-62 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19518428..19521810, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19412461..19415843, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44340 Neighboring gene uncharacterized protein Neighboring gene kish Neighboring gene 6-phosphofructo-2-kinase Neighboring gene CoRest Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TDP-43 Proteinopathy Causes Broad Metabolic Alterations including TCA Cycle Intermediates and Dopamine Levels in Drosophila Models of ALS. Loganathan S, et al. Metabolites, 2022 Jan 21. PMID 35208176, Free PMC Article
    2. The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission. Ugur B, et al. Cell Rep, 2017 Dec 26. PMID 29281828, Free PMC Article
    3. Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset. Jeong J, et al. PLoS Genet, 2021 Oct. PMID 34714823, Free PMC Article
    4. Cis-regulatory variation is typically polyallelic in Drosophila. Gruber JD, et al. Genetics, 2009 Feb. PMID 19064705, Free PMC Article
    5. A proteomic approach reveals the differential protein expression in Drosophila melanogaster treated with red ginseng extract (Panax ginseng). Liu QX, et al. J Ginseng Res, 2018 Jul. PMID 29983616, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A role for isocitrate dehydrogenase 3a (idh3a), a Krebs cycle enzyme, in neurotransmission, is reported.
      Title: The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isocitrate dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isocitrate dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in isocitrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of isocitrate dehydrogenase complex (NAD+) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    isocitrate dehydrogenase 3a
    Names
    CG12233-PA
    CG12233-PC
    CG12233-PD
    Idh3a-PA
    Idh3a-PC
    Idh3a-PD
    Lethal(1)G0156
    isocitrate dehydrogenase
    l(1)G0156
    lethal (1) G0156
    NP_001259705.1
    NP_573388.1
    NP_728257.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19518428..19521810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167657.3 → NP_728257.2  isocitrate dehydrogenase 3a, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728257.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VWH4
      Conserved Domains (1) summary
      cl00445
      Location:23 → 354
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    2. NM_133160.2 → NP_573388.1  isocitrate dehydrogenase 3a, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573388.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VWH4
      Related
      FBpp0074549
      Conserved Domains (1) summary
      cl00445
      Location:23 → 354
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    3. NM_001272776.1 → NP_001259705.1  isocitrate dehydrogenase 3a, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259705.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E4NKP2, Q8IQW9, Q8SXH8, Q9VWH4
      Conserved Domains (1) summary
      cl00445
      Location:46 → 377
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWH4.1 Q9VWH4

    Gene LinkOut

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