Mdh2 Malate dehydrogenase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mdh2provided by FlyBase
Official Full Name: Malate dehydrogenase 2provided by FlyBase
Primary source: FLYBASE:FBgn0262559
Locus tag: Dmel_CG7998
See related: AllianceGenome:FB:FBgn0262559
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG 7998; CG7998; Dmel\CG7998; l(3)psg7; Mdh; MDH-2; mdh2; MDH2; mMdh; psg7
Summary: Enables malate dehydrogenase activity. Involved in instar larval or pupal development; positive regulation of programmed cell death; and tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval digestive system; embryonic/larval fat body; and germline cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18226396..18228718)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14052118..14054440)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables L-malate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-malate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables malate dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in larval midgut cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pupal development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland histolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

Names: CG7998-PA; L-Malate dehydrogenase; Mdh2-PA; lethal (3) persistent salivary gland 7; malate dehydrogenase; malate dehydrogenase (mitochondrial); malic DH; mitochondrial malate dehydrogenase; mitochondrial-Mdh

NP_650696.1

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The following sections contain reference sequences that belong to a specific genome build. Explain