Agtr2 angiotensin II receptor, type 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Agtr2provided by MGI
Official Full Name: angiotensin II receptor, type 2provided by MGI
Primary source: MGI:MGI:87966
See related: Ensembl:ENSMUSG00000068122 AllianceGenome:MGI:87966
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables angiotensin type II receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; metanephros development; and positive regulation of branching involved in ureteric bud morphogenesis. Acts upstream of or within angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure; brain renin-angiotensin system; and inflammatory response. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and limb. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypoglycemia; intellectual disability; and vesicoureteral reflux. Orthologous to human AGTR2 (angiotensin II receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in limb E14.5 (RPKM 70.4) and CNS E14 (RPKM 3.9) See more
Orthologs: human all
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Genomic context

Location:: X A2; X 16.71 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (21350863..21355072)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (21484624..21488833)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Angiotensin II type 2 receptor as a novel activator of brown adipose tissue in obesity.
Title: Angiotensin II type 2 receptor as a novel activator of brown adipose tissue in obesity.
Activation of angiotensin II type 2 receptor attenuates lung injury of collagen-induced arthritis by alleviating endothelial cell injury and promoting Ly6C[lo] monocyte transition.
Title: Activation of angiotensin II type 2 receptor attenuates lung injury of collagen-induced arthritis by alleviating endothelial cell injury and promoting Ly6C(lo) monocyte transition.
AT2 Receptor Stimulation Inhibits Vascular Smooth Muscle Cell Senescence Induced by Angiotensin II and Hyperglycemia.
Title: AT2 Receptor Stimulation Inhibits Vascular Smooth Muscle Cell Senescence Induced by Angiotensin II and Hyperglycemia.
AT2 activation does not influence brain damage in the early phase after experimental traumatic brain injury in male mice.
Title: AT2 activation does not influence brain damage in the early phase after experimental traumatic brain injury in male mice.
Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice.
Title: Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice.
The Receptor AT1 Appears to Be Important for the Maintenance of Bone Mass and AT2 Receptor Function in Periodontal Bone Loss Appears to Be Regulated by AT1 Receptor.
Title: The Receptor AT1 Appears to Be Important for the Maintenance of Bone Mass and AT2 Receptor Function in Periodontal Bone Loss Appears to Be Regulated by AT1 Receptor.
In Aged Females, the Enhanced Pressor Response to Angiotensin II Is Attenuated By Estrogen Replacement via an Angiotensin Type 2 Receptor-Mediated Mechanism.
Title: In Aged Females, the Enhanced Pressor Response to Angiotensin II Is Attenuated By Estrogen Replacement via an Angiotensin Type 2 Receptor-Mediated Mechanism.
Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging-Related Muscle Weakness in Male Mice.
Title: Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging-Related Muscle Weakness in Male Mice.
AT1 and AT2 Receptor Knockout Changed Osteonectin and Bone Density in Mice in Periodontal Inflammation Experimental Model.
Title: AT1 and AT2 Receptor Knockout Changed Osteonectin and Bone Density in Mice in Periodontal Inflammation Experimental Model.
Angiotensin type 2 receptors: Role in aging and neuroinflammation in the substantia nigra.
Title: Angiotensin type 2 receptors: Role in aging and neuroinflammation in the substantia nigra.

Submit: New GeneRIF Correction See all GeneRIFs (136)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (3) 1 citation

General gene information

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Markers

AW107640 (e-PCR)
- UniSTS:181279

Agtr2 (e-PCR), detects polymorphism
- UniSTS:265513

Agtr2 (e-PCR), detects polymorphism
- UniSTS:516681

Agtr2 (e-PCR), detects polymorphism
- UniSTS:499075

UniSTS:496533 (e-PCR)
- UniSTS:496533

Agtr2 (e-PCR), detects polymorphism
- UniSTS:496533

PMC153509P1 (e-PCR)
- UniSTS:271257

Agtr2 (e-PCR), detects polymorphism
- UniSTS:265641

RH136127 (e-PCR)
- UniSTS:210122

Agtr2 (e-PCR), detects polymorphism
- UniSTS:141053

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables angiotensin type II receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables angiotensin type II receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables angiotensin type II receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables angiotensin type II receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brain renin-angiotensin system	IDA Inferred from Direct Assay more info	PubMed
involved_in cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dexamethasone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cerebellar cortex development	ISO Inferred from Sequence Orthology more info
involved_in dopamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in kidney morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of icosanoid secretion	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neurotrophin TRK receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of norepinephrine secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nitric oxide-cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of metanephric glomerulus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of metanephros size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure by circulatory renin-angiotensin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renin-angiotensin regulation of aldosterone production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: type-2 angiotensin II receptor

Names: AT2 receptor; angiotensin II type-2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.