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    Adcy7 adenylate cyclase 7 [ Mus musculus (house mouse) ]

    Gene ID: 11513, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Adcy7provided by MGI
    Official Full Name
    adenylate cyclase 7provided by MGI
    Primary source
    MGI:MGI:102891
    See related
    Ensembl:ENSMUSG00000031659 AllianceGenome:MGI:102891
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables adenylate cyclase activity. Involved in cellular response to lithium ion; negative regulation of cytokine production involved in inflammatory response; and regulation of adaptive immune response. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human ADCY7 (adenylate cyclase 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen adult (RPKM 30.9), lung adult (RPKM 18.8) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 C3; 8 43.06 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (88998818..89056593)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (88272190..88329965)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene microRNA 7071 Neighboring gene HEAT repeat containing 3 Neighboring gene terminal nucleotidyltransferase 4B Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:90808880-90809067 Neighboring gene bromodomain containing 7 Neighboring gene STARR-positive B cell enhancer ABC_E6670 Neighboring gene predicted gene, 34751 Neighboring gene predicted gene, 39218

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of Adenylyl Cyclase Type 7 in Functions of BV-2 Microglia. Hu Y, et al. Int J Mol Sci, 2022 Dec 25. PMID 36613790, Free PMC Article
    2. Type 7 Adenylyl Cyclase is Involved in the Ethanol and CRF Sensitivity of GABAergic Synapses in Mouse Central Amygdala. Cruz MT, et al. Front Neurosci, 2011. PMID 21258618, Free PMC Article
    3. Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells. Watson PA, et al. J Biol Chem, 1994 Nov 18. PMID 7961850
    4. Distinct roles of adenylyl cyclase VII in regulating the immune responses in mice. Duan B, et al. J Immunol, 2010 Jul 1. PMID 20505140, Free PMC Article
    5. Lithium preferentially inhibits adenylyl cyclase V and VII isoforms. Mann L, et al. Int J Neuropsychopharmacol, 2008 Jun. PMID 18205980

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC141539

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylate cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within activation of adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cAMP biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to ethanol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to lithium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cytokine production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of adaptive immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenylate cyclase type 7
    Names
    ATP pyrophosphate-lyase 7
    adenylate cyclase type VII
    adenylyl cyclase 7
    adenylyl cyclase type VII
    NP_001032812.2
    NP_001032813.1
    NP_001103226.1
    NP_031432.2
    XP_006530643.1
    XP_011246579.1
    XP_011246580.1
    XP_011246581.1
    XP_011246582.1
    XP_011246583.1
    XP_011246584.1
    XP_030099104.1
    XP_036009618.1
    XP_036009619.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037723.3 → NP_001032812.2  adenylate cyclase type 7

      See identical proteins and their annotated locations for NP_001032812.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AK138911, AK155831, BB761797, BY208639
      Consensus CDS
      CCDS22509.1
      UniProtKB/Swiss-Prot
      P51829, Q3U3P2
      UniProtKB/TrEMBL
      Q3U1P1
      Related
      ENSMUSP00000132528.2, ENSMUST00000171456.9
      Conserved Domains (4) summary
      smart00044
      Location:227 → 431
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:890 → 1086
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:75 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    2. NM_001037724.4 → NP_001032813.1  adenylate cyclase type 7

      See identical proteins and their annotated locations for NP_001032813.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AK138911, AK155831, BB761797, BY205086
      Consensus CDS
      CCDS22509.1
      UniProtKB/Swiss-Prot
      P51829, Q3U3P2
      UniProtKB/TrEMBL
      Q3U1P1
      Related
      ENSMUSP00000096122.3, ENSMUST00000098521.4
      Conserved Domains (4) summary
      smart00044
      Location:227 → 431
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:890 → 1086
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:75 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    3. NM_001109756.1 → NP_001103226.1  adenylate cyclase type 7

      See identical proteins and their annotated locations for NP_001103226.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AK138911, AK155646, AK155831, BB761797
      Consensus CDS
      CCDS22509.1
      UniProtKB/Swiss-Prot
      P51829, Q3U3P2
      UniProtKB/TrEMBL
      Q3U1P1
      Related
      ENSMUSP00000129252.2, ENSMUST00000168545.8
      Conserved Domains (4) summary
      smart00044
      Location:227 → 431
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:890 → 1086
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:75 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    4. NM_007406.2 → NP_031432.2  adenylate cyclase type 7

      See identical proteins and their annotated locations for NP_031432.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC155170, AK138911, AK155831, BB761797, U12919
      Consensus CDS
      CCDS22509.1
      UniProtKB/Swiss-Prot
      P51829, Q3U3P2
      UniProtKB/TrEMBL
      Q3U1P1
      Related
      ENSMUSP00000130594.2, ENSMUST00000169037.9
      Conserved Domains (4) summary
      smart00044
      Location:227 → 431
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:890 → 1086
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:75 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      88998818..89056593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243244.1 → XP_030099104.1  adenylate cyclase type 7 isoform X1

      UniProtKB/TrEMBL
      Q3U1P1
      Conserved Domains (3) summary
      pfam00211
      Location:890 → 1085
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:75 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)

    2. XM_011248278.3 → XP_011246580.1  adenylate cyclase type 7 isoform X1

      See identical proteins and their annotated locations for XP_011246580.1

      UniProtKB/TrEMBL
      Q3U1P1
      Conserved Domains (3) summary
      pfam00211
      Location:890 → 1085
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:75 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)

    3. XM_036153725.1 → XP_036009618.1  adenylate cyclase type 7 isoform X1

      UniProtKB/TrEMBL
      Q3U1P1
      Conserved Domains (3) summary
      pfam00211
      Location:890 → 1085
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:75 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)

    4. XM_011248279.3 → XP_011246581.1  adenylate cyclase type 7 isoform X1

      See identical proteins and their annotated locations for XP_011246581.1

      UniProtKB/TrEMBL
      Q3U1P1
      Conserved Domains (3) summary
      pfam00211
      Location:890 → 1085
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:75 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)

    5. XM_011248277.3 → XP_011246579.1  adenylate cyclase type 7 isoform X1

      See identical proteins and their annotated locations for XP_011246579.1

      UniProtKB/TrEMBL
      Q3U1P1
      Conserved Domains (3) summary
      pfam00211
      Location:890 → 1085
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:75 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)

    6. XM_011248282.3 → XP_011246584.1  adenylate cyclase type 7 isoform X2

      UniProtKB/TrEMBL
      Q3U1P1
      Conserved Domains (3) summary
      pfam00211
      Location:890 → 1085
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:75 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)

    7. XM_036153726.1 → XP_036009619.1  adenylate cyclase type 7 isoform X3

      UniProtKB/TrEMBL
      Q3U1P1
      Conserved Domains (4) summary
      pfam00211
      Location:272 → 422
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:75 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)
      cl11967
      Location:890 → 936
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases

    8. XM_006530580.5 → XP_006530643.1  adenylate cyclase type 7 isoform X1

      See identical proteins and their annotated locations for XP_006530643.1

      UniProtKB/TrEMBL
      Q3U1P1
      Conserved Domains (3) summary
      pfam00211
      Location:890 → 1085
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:75 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)

    9. XM_011248280.1 → XP_011246582.1  adenylate cyclase type 7 isoform X1

      See identical proteins and their annotated locations for XP_011246582.1

      UniProtKB/TrEMBL
      Q3U1P1
      Conserved Domains (3) summary
      pfam00211
      Location:890 → 1085
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:75 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)

    10. XM_011248281.4 → XP_011246583.1  adenylate cyclase type 7 isoform X1

      See identical proteins and their annotated locations for XP_011246583.1

      UniProtKB/TrEMBL
      Q3U1P1
      Conserved Domains (3) summary
      pfam00211
      Location:890 → 1085
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:75 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)

    RNA

    1. XR_878769.4 RNA Sequence

    2. XR_004934749.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51829.2 GenPept UniProtKB/Swiss-Prot:P51829

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