Ctsc cathepsin C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctscprovided by MGI
Official Full Name: cathepsin Cprovided by MGI
Primary source: MGI:MGI:109553
See related: Ensembl:ENSMUSG00000030560 AllianceGenome:MGI:109553
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CatC; DPP1; DPPI
Summary: This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the dipeptidyl peptidase 1 light, heavy, and exclusion domain chains, which together comprise one subunit of the homotetrameric enzyme. This enzyme has amino dipeptidase activity and may play a role in the activation of granzymes during inflammation. Homozygous knockout mice for this gene exhibit impaired granzyme activation and enhanced survival in a sepsis model. [provided by RefSeq, Aug 2015]
Expression: Ubiquitous expression in lung adult (RPKM 8.0), mammary gland adult (RPKM 4.8) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D3; 7 49.11 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (87927233..87960083)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (88278024..88315861)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cathepsin C aggravates neuroinflammation via promoting production of CCL2 and CXCL2 in glial cells and neurons in a cryogenic brain lesion.
Title: Cathepsin C aggravates neuroinflammation via promoting production of CCL2 and CXCL2 in glial cells and neurons in a cryogenic brain lesion.
CTSC may promote macrophage towards M1 activation status through FAK-induced p38MAPK/NF-kappaB signaling pathway activation.
Title: Up-regulated cathepsin C induces macrophage M1 polarization through FAK-triggered p38 MAPK/NF-κB pathway.
Cathepsin C regulates neutrophil elastase activation and E-cadherin cleavage in acute pancreatitis.
Title: Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin.
The data suggest that CatC promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca(2+)-dependent PKC/p38MAPK/NF-kappaB pathway.
Title: Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca(2+)-dependent PKC/p38MAPK/NF-κB pathway.
During the active remyelinating phase, both CysF knockdown (CysFKD) and microglial-selective CatC overexpression (CatCOE) showed a worsening of the demyelination in Plp(4e/-) transgenic mice. Conversely, during the chronic demyelinating phase, CatC knockdown (CatCKD) ameliorated the demyelination. Our results suggest that the balance between CatC and CysF expression controls the demyelination and remyelination process.
Title: The balance between cathepsin C and cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model.
Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases.
Title: Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases.
A proteolytic cascade, involving cathepsins C and D, controls LLOMe-mediated necrosis.
Title: Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents.
Double immunofluorescence analysis showed that CTLA-2alpha was co-localized with cathepsin L, cathepsin C, and TINAGL1 in placenta.
Title: Identification and characterization of the interactive proteins with cytotoxic T-lymphocyte antigen-2α.
CatC has a role in the selective tuning of innate and adaptive immune responses, relevant to a chronic immune disease, such as atherosclerosis.
Title: Leukocyte cathepsin C deficiency attenuates atherosclerotic lesion progression by selective tuning of innate and adaptive immune responses.
Data indicate that all-trans retinoic acid (ATRA), which induces miR-23a expression, decreases cathepsin C (CTSC) expression and granzyme B activity leading to impaired NK cell cytotoxicity.
Title: All-trans retinoic acid (ATRA) induces miR-23a expression, decreases CTSC expression and granzyme B activity leading to impaired NK cell cytotoxicity.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU015263 (e-PCR)
- UniSTS:208151

Ctsc (e-PCR), detects polymorphism
- UniSTS:496024

AU015263 (e-PCR)
- UniSTS:159665

AI047818 (e-PCR)
- UniSTS:159666

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chloride ion binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables dipeptidyl-peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptidase activator activity involved in apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell mediated cytotoxicity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of myelination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of microglial cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to organic substance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dipeptidyl peptidase 1

Names: cathepsin J; dipeptidyl peptidase I; dipeptidyl transferase

NP_001298719.1

EC 3.4.14.1

NP_001399239.1

EC 3.4.14.1

NP_001399240.1

EC 3.4.14.1

NP_034112.3

EC 3.4.14.1

XP_006507383.1

EC 3.4.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311790.2 → NP_001298719.1 dipeptidyl peptidase 1 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 3' terminal exon, resulting in a frameshift and an early stop codon compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1. It is not known whether this isoform (2) is proteolytically processed in the same manner as isoform 1.

Source sequence(s)

AC124322

Consensus CDS

CCDS85332.1

UniProtKB/TrEMBL

Q3U7T5

Related

ENSMUSP00000147006.2, ENSMUST00000131108.9

Conserved Domains (1) summary

pfam08773
Location:25 → 106

CathepsinC_exc; Cathepsin C exclusion domain
NM_001412310.1 → NP_001399239.1 dipeptidyl peptidase 1 isoform 3 preproprotein

Status: REVIEWED

Source sequence(s)

AC124322
NM_001412311.1 → NP_001399240.1 dipeptidyl peptidase 1 isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AC124322
NM_009982.6 → NP_034112.3 dipeptidyl peptidase 1 isoform 1 preproprotein

See identical proteins and their annotated locations for NP_034112.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC124322

Consensus CDS

CCDS21438.1

UniProtKB/Swiss-Prot

O08853, P97821

UniProtKB/TrEMBL

Q3TIF1, Q3UAF5, Q3UBY5, Q8BQL3

Related

ENSMUSP00000032779.6, ENSMUST00000032779.12

Conserved Domains (3) summary

cd02621
Location:230 → 459

Peptidase_C1A_CathepsinC; Cathepsin C; also known as Dipeptidyl Peptidase I (DPPI), an atypical papain-like cysteine peptidase with chloride dependency and dipeptidyl aminopeptidase activity, resulting from its tetrameric structure which limits substrate access. Each subunit of ...

pfam04595
Location:168 → 204

Pox_I6; Poxvirus I6-like family

pfam08773
Location:26 → 138

CathepsinC_exc; Cathepsin C exclusion domain

RNA

NR_178180.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124322

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

87927233..87960083

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507320.5 → XP_006507383.1 dipeptidyl peptidase 1 isoform X2

Conserved Domains (1) summary

pfam08773
Location:25 → 106

CathepsinC_exc; Cathepsin C exclusion domain