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    Qpct glutaminyl-peptide cyclotransferase (glutaminyl cyclase) [ Mus musculus (house mouse) ]

    Gene ID: 70536, updated on 12-May-2024

    Summary

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    Official Symbol
    Qpctprovided by MGI
    Official Full Name
    glutaminyl-peptide cyclotransferase (glutaminyl cyclase)provided by MGI
    Primary source
    MGI:MGI:1917786
    See related
    Ensembl:ENSMUSG00000024084 AllianceGenome:MGI:1917786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730422A13Rik
    Summary
    Predicted to enable glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Predicted to be involved in peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase. Predicted to be located in extracellular region. Is expressed in several structures, including alimentary system; central nervous system; future brain; integumental system; and placenta. Orthologous to human QPCT (glutaminyl-peptide cyclotransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E18 (RPKM 17.4), testis adult (RPKM 10.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Qpct in Genome Data Viewer
    Location:
    17 E3; 17 49.83 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (79359335..79397807)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (79051906..79090378)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5629 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7 Neighboring gene protein kinase D3 Neighboring gene predicted gene, 41622 Neighboring gene STARR-seq mESC enhancer starr_43275 Neighboring gene STARR-seq mESC enhancer starr_43276 Neighboring gene STARR-seq mESC enhancer starr_43277 Neighboring gene STARR-seq mESC enhancer starr_43278 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_43280 Neighboring gene CDC42 effector protein 3 Neighboring gene predicted gene, 17315

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct. Guo J, et al. Mol Cells, 2015 Oct. PMID 26447138, Free PMC Article
    2. Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC. Höfling C, et al. Int J Dev Neurosci, 2014 Aug. PMID 24886834
    3. Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development. Schilling S, et al. J Biol Chem, 2011 Apr 22. PMID 21330373, Free PMC Article
    4. Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain. Hartlage-Rübsamen M, et al. Int J Dev Neurosci, 2009 Dec. PMID 19699792
    5. Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase. Schilling S, et al. Biochemistry, 2005 Oct 11. PMID 16201766

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Authors identified a placenta-specific imprinted gene Qpct. Results show that Qpct is widely expressed during early embryonic development and can be detected in the telencephalon, midbrain, and rhombencephalon at E9.5-E11.5.
      Title: Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct.
    2. co-regulation of the enzyme glutaminyl cyclase and its substrate TRH was reflected by a co-induction of both proteins in reactive astrocytes in proximity of Abeta deposits
      Title: Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes.
    3. This study provide a thorough comparative characterization of the glutaminyl cyclases QC and isoQC in defined brain regions of different inbred and outbred mouse strains
      Title: Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC.
    4. This study presents a first comparison of two mammalian QCs (mouse and human)containing typical, conserved post-translational modifications.
      Title: Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center.
    5. Glutaminyl cyclase in a mouse knockout model has a role in hypothyroidism but not hypogonadism
      Title: Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development.
    6. QC is crucial for modulating AbetapE3-42 levels in vivo and prove on a genetic base the concept that reduction of QC activity is a promising new therapeutic approach for AD.
      Title: Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice.
    7. Murine isoQC proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC.
      Title: Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics.
    8. Results describe the expression of glutaminyl cyclase throughout the mouse brain during early postnatal development.
      Title: Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain.
    9. The observations of this study indicated that brain ischemia might be a pathogenic factor of alzheimer disease through increasing BACE1, cathepsin B, and glutaminyl cyclase.
      Title: Alterations in mRNA expression of BACE1, cathepsin B, and glutaminyl cyclase in mice ischemic brain.
    10. QC is a zinc-dependent catalyst
      Title: Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutaminyl-peptide cyclotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutaminyl-peptide cyclotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutaminyl-peptide cyclotransferase
    Names
    QC
    glutaminyl cyclase
    glutaminyl-tRNA cyclotransferase
    NP_001303658.1
    NP_081731.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316729.1 → NP_001303658.1  glutaminyl-peptide cyclotransferase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK045974, AK148394, CK624808
      Consensus CDS
      CCDS89158.1
      UniProtKB/Swiss-Prot
      Q8BH20, Q8VE07, Q9CYK2
      UniProtKB/TrEMBL
      A0A3B2W7G1
      Related
      ENSMUSP00000156493.2, ENSMUST00000233916.2
      Conserved Domains (1) summary
      cd03880
      Location:41 → 310
      M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

    2. NM_027455.3 → NP_081731.1  glutaminyl-peptide cyclotransferase isoform 1 precursor

      See identical proteins and their annotated locations for NP_081731.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK045974, AK148394
      Consensus CDS
      CCDS28983.1
      UniProtKB/Swiss-Prot
      Q8BH20, Q8VE07, Q9CYK2
      UniProtKB/TrEMBL
      A0A0R4J0G6
      Related
      ENSMUSP00000038732.5, ENSMUST00000040789.6
      Conserved Domains (1) summary
      cd03880
      Location:60 → 359
      M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      79359335..79397807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CYK2.2 GenPept UniProtKB/Swiss-Prot:Q9CYK2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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