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    Serinc2 serine incorporator 2 [ Mus musculus (house mouse) ]

    Gene ID: 230779, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Serinc2provided by MGI
    Official Full Name
    serine incorporator 2provided by MGI
    Primary source
    MGI:MGI:1919132
    See related
    Ensembl:ENSMUSG00000023232 AllianceGenome:MGI:1919132
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TDE2; Tde2l; FKSG84; 2310004K20Rik
    Summary
    Predicted to be involved in phosphatidylserine metabolic process; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity; and positive regulation of serine C-palmitoyltransferase activity. Predicted to be integral component of membrane. Predicted to be active in membrane. Orthologous to human SERINC2 (serine incorporator 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in stomach adult (RPKM 101.5), colon adult (RPKM 80.2) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Serinc2 in Genome Data Viewer
    Location:
    4 D2.2; 4 63.43 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (130147289..130172993, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (130253495..130279218, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene leucine decarboxylase 1 Neighboring gene predicted gene, 46724 Neighboring gene predicted gene, 34957 Neighboring gene STARR-seq mESC enhancer starr_11521 Neighboring gene fatty acid binding protein 3, muscle and heart Neighboring gene zinc finger, CCHC domain containing 17 Neighboring gene predicted gene, 35074

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in phosphatidylserine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine incorporator 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253386.1 → NP_001240315.1  serine incorporator 2 isoform 2

      See identical proteins and their annotated locations for NP_001240315.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AK075863, AK158914, BE956082
      Consensus CDS
      CCDS57301.1
      UniProtKB/TrEMBL
      B2KFY0
      Related
      ENSMUSP00000112535.2, ENSMUST00000122374.8
      Conserved Domains (1) summary
      pfam03348
      Location:1 → 393
      Serinc; Serine incorporator (Serinc)

    2. NM_001356465.1 → NP_001343394.1  serine incorporator 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AK075863, AK158914, AL606925, BE956082
      Consensus CDS
      CCDS57301.1
      UniProtKB/TrEMBL
      B2KFY0
      Conserved Domains (1) summary
      pfam03348
      Location:1 → 393
      Serinc; Serine incorporator (Serinc)

    3. NM_172702.3 → NP_766290.2  serine incorporator 2 isoform 1

      See identical proteins and their annotated locations for NP_766290.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AA986627, BE956082, BG077215, BU511121, CB055666
      Consensus CDS
      CCDS51310.1
      UniProtKB/Swiss-Prot
      Q8K0E7
      UniProtKB/TrEMBL
      Q8C6D8
      Related
      ENSMUSP00000101618.2, ENSMUST00000105996.8
      Conserved Domains (1) summary
      pfam03348
      Location:17 → 448
      Serinc; Serine incorporator (Serinc)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      130147289..130172993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503063.3 → XP_006503126.1  serine incorporator 2 isoform X1

      See identical proteins and their annotated locations for XP_006503126.1

      UniProtKB/TrEMBL
      E9Q7Q6, Q8C6D8
      Related
      ENSMUSP00000113044.3, ENSMUST00000120126.9
      Conserved Domains (1) summary
      pfam03348
      Location:25 → 457
      Serinc; Serine incorporator (Serinc)

    2. XM_036164063.1 → XP_036019956.1  serine incorporator 2 isoform X2

      UniProtKB/TrEMBL
      B2KFY0
      Conserved Domains (1) summary
      pfam03348
      Location:1 → 393
      Serinc; Serine incorporator (Serinc)

    3. XM_006503064.5 → XP_006503127.1  serine incorporator 2 isoform X2

      See identical proteins and their annotated locations for XP_006503127.1

      UniProtKB/TrEMBL
      B2KFY0
      Conserved Domains (1) summary
      pfam03348
      Location:1 → 393
      Serinc; Serine incorporator (Serinc)

    4. XM_030253463.2 → XP_030109323.1  serine incorporator 2 isoform X2

      UniProtKB/TrEMBL
      B2KFY0
      Conserved Domains (1) summary
      pfam03348
      Location:1 → 393
      Serinc; Serine incorporator (Serinc)

    5. XM_030253461.2 → XP_030109321.1  serine incorporator 2 isoform X2

      UniProtKB/TrEMBL
      B2KFY0
      Conserved Domains (1) summary
      pfam03348
      Location:1 → 393
      Serinc; Serine incorporator (Serinc)

    6. XM_030253462.2 → XP_030109322.1  serine incorporator 2 isoform X2

      UniProtKB/TrEMBL
      B2KFY0
      Conserved Domains (1) summary
      pfam03348
      Location:1 → 393
      Serinc; Serine incorporator (Serinc)

    7. XM_006503065.5 → XP_006503128.1  serine incorporator 2 isoform X2

      See identical proteins and their annotated locations for XP_006503128.1

      UniProtKB/TrEMBL
      B2KFY0
      Conserved Domains (1) summary
      pfam03348
      Location:1 → 393
      Serinc; Serine incorporator (Serinc)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0E7.1 GenPept UniProtKB/Swiss-Prot:Q8K0E7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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