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    Slfn9 schlafen 9 [ Mus musculus (house mouse) ]

    Gene ID: 237886, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Slfn9provided by MGI
    Official Full Name
    schlafen 9provided by MGI
    Primary source
    MGI:MGI:2445121
    See related
    Ensembl:ENSMUSG00000069793 AllianceGenome:MGI:2445121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9830137M10Rik
    Summary
    Predicted to enable endoribonuclease activity; tRNA binding activity; and zinc ion binding activity. Predicted to be involved in defense response to virus; rRNA catabolic process; and tRNA catabolic process. Located in nucleus. Orthologous to human SLFN11 (schlafen family member 11) and SLFN13 (schlafen family member 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 2.0), CNS E11.5 (RPKM 1.6) and 20 other tissues See more
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    Genomic context

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    Location:
    11 C; 11 50.3 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (82865142..82883041, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (82974316..82991830, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene schlafen 5, opposite strand Neighboring gene schlafen 5 Neighboring gene SET domain-containing protein 8 pseudogene Neighboring gene microRNA 7679 Neighboring gene schlafen 8 Neighboring gene 60S ribosomal protein L12 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Subcellular localization of the Schlafen protein family. Neumann B, et al. Biochem Biophys Res Commun, 2008 May 23. PMID 18355440
    2. Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence. Bustos O, et al. Gene, 2009 Nov 1. PMID 19619625, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.
      Title: Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    schlafen family member 9
    Names
    Schlafen family member 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172796.2 → NP_766384.2  schlafen family member 9

      See identical proteins and their annotated locations for NP_766384.2

      Status: VALIDATED

      Source sequence(s)
      AK036579, AY261800
      Consensus CDS
      CCDS25154.1
      UniProtKB/Swiss-Prot
      A0A0A0MQG6, B1ARD6, Q7TME8, Q7TME9, Q80VG8, Q8C7F7, Q8CB82
      UniProtKB/TrEMBL
      A0A1G5SL47
      Related
      ENSMUSP00000044435.6, ENSMUST00000038211.13
      Conserved Domains (3) summary
      PHA02782
      Location:45 → 346
      PHA02782; hypothetical protein; Provisional
      pfam13538
      Location:852 → 895
      UvrD_C_2; UvrD-like helicase C-terminal domain
      pfam09848
      Location:595 → 765
      DUF2075; Uncharacterized conserved protein (DUF2075)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      82865142..82883041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533235.5 → XP_006533298.1  schlafen family member 9 isoform X1

      See identical proteins and their annotated locations for XP_006533298.1

      UniProtKB/Swiss-Prot
      A0A0A0MQG6, B1ARD6, Q7TME8, Q7TME9, Q80VG8, Q8C7F7, Q8CB82
      UniProtKB/TrEMBL
      A0A1G5SL47
      Conserved Domains (3) summary
      PHA02782
      Location:45 → 346
      PHA02782; hypothetical protein; Provisional
      pfam13538
      Location:852 → 895
      UvrD_C_2; UvrD-like helicase C-terminal domain
      pfam09848
      Location:595 → 765
      DUF2075; Uncharacterized conserved protein (DUF2075)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1ARD6.1 GenPept UniProtKB/Swiss-Prot:B1ARD6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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