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    Ppm1e protein phosphatase 1E (PP2C domain containing) [ Mus musculus (house mouse) ]

    Gene ID: 320472, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ppm1eprovided by MGI
    Official Full Name
    protein phosphatase 1E (PP2C domain containing)provided by MGI
    Primary source
    MGI:MGI:2444096
    See related
    Ensembl:ENSMUSG00000046442 AllianceGenome:MGI:2444096
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    POPX1; PP2CH; mKIAA1072; B930008A12Rik
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Involved in protein dephosphorylation. Predicted to be located in mitochondrion; nucleolus; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in central nervous system and retina. Orthologous to human PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in frontal lobe adult (RPKM 37.0), CNS E18 (RPKM 18.9) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppm1e in Genome Data Viewer
    Location:
    11 C; 11 51.99 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87117724..87249884, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87226906..87358994, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E26 Neighboring gene proline rich 11 Neighboring gene microRNA 301 Neighboring gene spindle and kinetochore associated complex subunit 2 Neighboring gene STARR-seq mESC enhancer starr_30287 Neighboring gene tripartite motif-containing 37 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87059058-87059211 Neighboring gene predicted gene, 33937 Neighboring gene predicted gene, 22883 Neighboring gene STARR-positive B cell enhancer ABC_E3005 Neighboring gene RAD51 paralog C Neighboring gene VISTA enhancer mm264 Neighboring gene testis expressed gene 14 intercellular bridge forming factor Neighboring gene U1a1 small nuclear RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells. Chida T, et al. Biochem J, 2013 Feb 1. PMID 23088624
    2. Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling. Yorgan TA, et al. Bone, 2019 Oct. PMID 31202927
    3. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article
    4. RNA binding proteins co-localize with small tau inclusions in tauopathy. Maziuk BF, et al. Acta Neuropathol Commun, 2018 Aug 1. PMID 30068389, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-threonine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1E
    Names
    ca(2+)/calmodulin-dependent protein kinase phosphatase N
    caMKN
    caMKP-N
    caMKP-nucleus
    partner of PIX 1
    partner of PIX-alpha
    partner of PIXA
    NP_796141.2
    XP_036012659.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177167.4 → NP_796141.2  protein phosphatase 1E

      See identical proteins and their annotated locations for NP_796141.2

      Status: VALIDATED

      Source sequence(s)
      AL596130
      Consensus CDS
      CCDS25211.1
      UniProtKB/Swiss-Prot
      Q5SX30, Q80TL0, Q8BGM6, Q8CB81
      UniProtKB/TrEMBL
      B2KGP3
      Related
      ENSMUSP00000061278.5, ENSMUST00000055438.5
      Conserved Domains (1) summary
      cd00143
      Location:227 → 485
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      87117724..87249884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156766.1 → XP_036012659.1  protein phosphatase 1E isoform X1

      Conserved Domains (1) summary
      cd00143
      Location:233 → 422
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80TL0.2 GenPept UniProtKB/Swiss-Prot:Q80TL0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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