IGFBP2 insulin like growth factor binding protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IGFBP2provided by HGNC
Official Full Name: insulin like growth factor binding protein 2provided by HGNC
Primary source: HGNC:HGNC:5471
See related: Ensembl:ENSG00000115457 MIM:146731; AllianceGenome:HGNC:5471
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IBP2; IGF-BP53
Summary: The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]
Expression: Broad expression in liver (RPKM 67.6), stomach (RPKM 67.2) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q35

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (216632828..216664436)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (217115243..217146861)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (217497551..217529159)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway.
Title: The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway.
Role of increased IGFBP2 in trophoblast cell proliferation and recurrent spontaneous abortion development: A pilot study.
Title: Role of increased IGFBP2 in trophoblast cell proliferation and recurrent spontaneous abortion development: A pilot study.
Cancer-associated fibroblast-associated gene IGFBP2 promotes glioma progression through induction of M2 macrophage polarization.
Title: Cancer-associated fibroblast-associated gene IGFBP2 promotes glioma progression through induction of M2 macrophage polarization.
METTL3-mediated HOTAIRM1 promotes vasculogenic mimicry icontributionsn glioma via regulating IGFBP2 expression.
Title: METTL3-mediated HOTAIRM1 promotes vasculogenic mimicry icontributionsn glioma via regulating IGFBP2 expression.
Insulin-like growth factor binding protein-2 as a biomarker for lupus nephritis.
Title: Insulin-like growth factor binding protein-2 as a biomarker for lupus nephritis.
Insulin-like growth factor binding protein 2: a core biomarker of left ventricular dysfunction in dilated cardiomyopathy.
Title: Insulin-like growth factor binding protein 2: a core biomarker of left ventricular dysfunction in dilated cardiomyopathy.
Plasma IGFBP-2 levels reveal heterogeneity in hepatic fat content in adults with excess visceral adiposity.
Title: Plasma IGFBP-2 levels reveal heterogeneity in hepatic fat content in adults with excess visceral adiposity.
Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients.
Title: Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients.
IGFBP2 secretion by mammary adipocytes limits breast cancer invasion.
Title: IGFBP2 secretion by mammary adipocytes limits breast cancer invasion.
Associations of insulin-like growth factor binding protein-2 with metabolic profile and hepatic fat deposition in asymptomatic men and women.
Title: Associations of insulin-like growth factor binding protein-2 with metabolic profile and hepatic fat deposition in asymptomatic men and women.

Submit: New GeneRIF Correction See all GeneRIFs (232)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpu	vpu	The gene expression of insulin-like growth factor binding protein 2 (IGFBP2) increases in cells infected with vpu-deficient HIV-1 compared to cells infected with the wild-type virus, indicating that HIV-1 Vpu downregulates IGFBP2 protein expression	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-M35410 (e-PCR)
- UniSTS:26925

D8S2279 (e-PCR)
- UniSTS:473907

D22S1584 (e-PCR)
- UniSTS:473695

bovineIGFBP2 (e-PCR)
- UniSTS:478835

RH91510 (e-PCR)
- UniSTS:84915

IGFB2 (e-PCR)
- UniSTS:105161

RH79685 (e-PCR)
- UniSTS:90593

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables insulin-like growth factor I binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor I binding	IDA Inferred from Direct Assay more info	PubMed
enables insulin-like growth factor II binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor II binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in female pregnancy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of activated T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of insulin-like growth factor receptor signaling pathway	IC Inferred by Curator more info	PubMed
involved_in regulation of insulin-like growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to estrogen	IEA Inferred from Electronic Annotation more info
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to nutrient	IEA Inferred from Electronic Annotation more info
involved_in response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: insulin-like growth factor-binding protein 2

Names: IGF-binding protein 2; insulin-like growth factor binding protein 2, 36kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000597.3 → NP_000588.3 insulin-like growth factor-binding protein 2 isoform a precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

BC071967, M35410

Consensus CDS

CCDS42815.1

UniProtKB/Swiss-Prot

P18065, Q14619, Q9UCL3

Related

ENSP00000233809.4, ENST00000233809.9

Conserved Domains (2) summary

smart00121
Location:40 → 132

IB; Insulin growth factor-binding protein homologues

pfam00086
Location:227 → 306

Thyroglobulin_1; Thyroglobulin type-1 repeat
NM_001313990.2 → NP_001300919.1 insulin-like growth factor-binding protein 2 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AC007563, BC004312, BE735562

Consensus CDS

CCDS82570.1

UniProtKB/TrEMBL

C9JMY1

Related

ENSP00000389646.1, ENST00000456764.1

Conserved Domains (1) summary

pfam00086
Location:83 → 162

Thyroglobulin_1; Thyroglobulin type-1 repeat
NM_001313992.2 → NP_001300921.1 insulin-like growth factor-binding protein 2 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).

Source sequence(s)

BC004312, CV810939

UniProtKB/Swiss-Prot

P18065

Conserved Domains (1) summary

cd00191
Location:60 → 140

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
NM_001313993.2 → NP_001300922.1 insulin-like growth factor-binding protein 2 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).

Source sequence(s)

AC073321, BC004312, CN431340

UniProtKB/Swiss-Prot

P18065

Conserved Domains (1) summary

cd00191
Location:60 → 140

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases