Prdx2 peroxiredoxin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prdx2provided by MGI
Official Full Name: peroxiredoxin 2provided by MGI
Primary source: MGI:MGI:109486
See related: Ensembl:ENSMUSG00000005161 AllianceGenome:MGI:109486
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TR; PRP; TPx; TSA; TDX1; NkefB; PrxII; TPx-B; Tdpx1; Torin; Band-8
Summary: Predicted to enable thioredoxin peroxidase activity. Involved in positive regulation of blood coagulation and removal of superoxide radicals. Acts upstream of or within several processes, including negative regulation of NF-kappaB transcription factor activity; regulation of signal transduction; and respiratory burst involved in inflammatory response. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; limb; reproductive system; and sensory organ. Orthologous to human PRDX2 (peroxiredoxin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E14 (RPKM 507.8), liver E14.5 (RPKM 504.3) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C3; 8 41.4 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (85696251..85701440)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (84969622..84974811)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intracerebral hemorrhage-induced brain injury in mice: The role of peroxiredoxin 2-Toll-like receptor 4 inflammatory axis.
Title: Intracerebral hemorrhage-induced brain injury in mice: The role of peroxiredoxin 2-Toll-like receptor 4 inflammatory axis.
Correlation between PRDX2 and spermatogenesis under oxidative stress.
Title: Correlation between PRDX2 and spermatogenesis under oxidative stress.
Peroxiredoxin 2 deficiency does not affect insulin resistance and oxidative stress in high-fat diet-fed obese mice.
Title: Peroxiredoxin 2 deficiency does not affect insulin resistance and oxidative stress in high-fat diet-fed obese mice.
Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2.
Title: Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2.
Active hematopoiesis triggers exosomal release of PRDX2 that promotes osteoclast formation.
Title: Active hematopoiesis triggers exosomal release of PRDX2 that promotes osteoclast formation.
Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm.
Title: Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm.
Peroxiredoxin 2 deficiency reduces white adipogenesis due to the excessive ROS generation.
Title: Peroxiredoxin 2 deficiency reduces white adipogenesis due to the excessive ROS generation.
Peroxiredoxin II with dermal mesenchymal stem cells accelerates wound healing.
Title: Peroxiredoxin II with dermal mesenchymal stem cells accelerates wound healing.
Involvement of peroxiredoxin 2 in cumulus expansion and oocyte maturation in mice.
Title: Involvement of peroxiredoxin 2 in cumulus expansion and oocyte maturation in mice.
BMP2-induced osteogenic gene expression and alkaline phosphatase activity were higher in Prx II knockout (KO) cells than they were in wild-type.
Title: Peroxiredoxin II negatively regulates BMP2-induced osteoblast differentiation and bone formation via PP2A Cα-mediated Smad1/5/9 dephosphorylation.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tdpx-ps2 (e-PCR), detects polymorphism
- UniSTS:259335

Tdpx-ps1 (e-PCR), detects polymorphism
- UniSTS:259336

D19S627E (e-PCR)
- UniSTS:150551

X82067 (e-PCR)
- UniSTS:163442

RH136582 (e-PCR)
- UniSTS:210562

Prdx2 (e-PCR), detects polymorphism
- UniSTS:525994

UniSTS:234183 (e-PCR)
- UniSTS:234183

Prdx2 (e-PCR), detects polymorphism
- UniSTS:144589

Prdx2 (e-PCR), detects polymorphism
- UniSTS:532435

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antioxidant activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	TAS Traceable Author Statement more info	PubMed
enables peroxiredoxin activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables selenium binding	TAS Traceable Author Statement more info	PubMed
enables thioredoxin peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioredoxin peroxidase activity	ISO Inferred from Sequence Orthology more info
enables thioredoxin peroxidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables thioredoxin peroxidase activity	TAS Traceable Author Statement more info	PubMed
enables thioredoxin-dependent peroxiredoxin activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to tumor cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hydrogen peroxide catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hydrogen peroxide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of lipopolysaccharide-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of hydrogen peroxide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in removal of superoxide radicals	IBA Inferred from Biological aspect of Ancestor more info
involved_in removal of superoxide radicals	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in removal of superoxide radicals	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within respiratory burst involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to oxidative stress	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within thymus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in mitochondrion	HDA more info	PubMed
located_in myelin sheath	HDA more info	PubMed

General protein information

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Preferred Names: peroxiredoxin-2

Names: Calpromotin; Prx II-1; Trx dependent peroxide reductase 1; protector protein; thiol-specific antioxidant protein; thioredoxin peroxidase 1; thioredoxin reductase; thioredoxin-dependent peroxide reductase 1; thioredoxin-dependent peroxiredoxin 2

NP_001304314.1

EC 1.11.1.24

NP_035693.3

EC 1.11.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001317385.1 → NP_001304314.1 peroxiredoxin-2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC163703, AK005225, BC086783, CX238307, DV051712

Consensus CDS

CCDS40416.1

UniProtKB/Swiss-Prot

O88376, Q60796, Q61171, Q9CWJ4, Q9DB49

UniProtKB/TrEMBL

Q5M9N9

Related

ENSMUSP00000105356.2, ENSMUST00000109734.8

Conserved Domains (2) summary

PTZ00253
Location:1 → 195

PTZ00253; tryparedoxin peroxidase; Provisional

cd03015
Location:8 → 179

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
NM_011563.6 → NP_035693.3 peroxiredoxin-2

See identical proteins and their annotated locations for NP_035693.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK005225, AK008433, CD773819

Consensus CDS

CCDS40416.1

UniProtKB/Swiss-Prot

O88376, Q60796, Q61171, Q9CWJ4, Q9DB49

UniProtKB/TrEMBL

Q5M9N9

Related

ENSMUSP00000005292.9, ENSMUST00000005292.15

Conserved Domains (2) summary

PTZ00253
Location:1 → 195

PTZ00253; tryparedoxin peroxidase; Provisional

cd03015
Location:8 → 179

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...