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    Fto FTO alpha-ketoglutarate dependent dioxygenase [ Mus musculus (house mouse) ]

    Gene ID: 26383, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ftoprovided by MGI
    Official Full Name
    FTO alpha-ketoglutarate dependent dioxygenaseprovided by MGI
    Primary source
    MGI:MGI:1347093
    See related
    Ensembl:ENSMUSG00000055932 AllianceGenome:MGI:1347093
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1752
    Summary
    Enables DNA-N1-methyladenine dioxygenase activity; oxidative DNA demethylase activity; and oxidative RNA demethylase activity. Involved in several processes, including nucleic acid metabolic process; regulation of respiratory system process; and regulation of white fat cell proliferation. Located in nucleus. Is expressed in several structures, including gonad; hemolymphoid system gland; liver; lung; and salivary gland. Human ortholog(s) of this gene implicated in obesity. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 31.5), whole brain E14.5 (RPKM 30.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 C5; 8 44.34 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (92039995..92395061)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (91313367..91668433)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene Rpgrip1-like Neighboring gene abhydrolase domain containing 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22299 Neighboring gene predicted gene, 36163 Neighboring gene RIKEN cDNA 4831440D22 gene Neighboring gene STARR-seq mESC enhancer starr_22306 Neighboring gene STARR-seq mESC enhancer starr_22308 Neighboring gene uncharacterized LOC118567558 Neighboring gene STARR-seq mESC enhancer starr_22309 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FTO-dependent m(6)A regulates muscle fiber remodeling in an NFATC1-YTHDF2 dependent manner. Wang W, et al. Clin Epigenetics, 2023 Jul 5. PMID 37408034, Free PMC Article
    2. Cerebroprotective Role of N(6)-Methyladenosine Demethylase FTO (Fat Mass and Obesity-Associated Protein) After Experimental Stroke. Chokkalla AK, et al. Stroke, 2023 Jan. PMID 36321453, Free PMC Article
    3. The m(6)A demethylase FTO promotes renal epithelial-mesenchymal transition by reducing the m(6)A modification of lncRNA GAS5. Li X, et al. Cytokine, 2022 Nov. PMID 36058192
    4. N6-methyladenosine demethylase FTO regulates inflammatory cytokine secretion and tight junctions in retinal pigment epithelium cells. Tang S, et al. Clin Immunol, 2022 Aug. PMID 35878734
    5. FTO mediates LINE1 m(6)A demethylation and chromatin regulation in mESCs and mouse development. Wei J, et al. Science, 2022 May 27. PMID 35511947, Free PMC Article

    See all (130) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of the m6A/m demethylase FTO in memory is both task and sex-dependent in mice.
      Title: The role of the m6A/m demethylase FTO in memory is both task and sex-dependent in mice.
    2. MicroRNA-192-5p downregulates Fat Mass and Obesity-associated Protein to aggravate renal ischemia/reperfusion injury.
      Title: MicroRNA-192-5p downregulates Fat Mass and Obesity-associated Protein to aggravate renal ischemia/reperfusion injury.
    3. FTO regulates osteoclast development by modulating the proliferation and apoptosis of osteoclast precursors in inflammatory conditions.
      Title: FTO regulates osteoclast development by modulating the proliferation and apoptosis of osteoclast precursors in inflammatory conditions.
    4. A novel PDIA3/FTO/USP20 positive feedback regulatory loop induces osteogenic differentiation of preosteoblast in osteoporosis.
      Title: A novel PDIA3/FTO/USP20 positive feedback regulatory loop induces osteogenic differentiation of preosteoblast in osteoporosis.
    5. Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury.
      Title: Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury.
    6. FTO-mediated m6A mRNA demethylation aggravates renal fibrosis by targeting RUNX1 and further enhancing PI3K/AKT pathway.
      Title: FTO-mediated m6A mRNA demethylation aggravates renal fibrosis by targeting RUNX1 and further enhancing PI3K/AKT pathway.
    7. Oxidative stress-mediated activation of FTO exacerbates impairment of the epithelial barrier by up-regulating IKBKB via N6-methyladenosine-dependent mRNA stability in asthmatic mice exposed to PM2.5.
      Title: Oxidative stress-mediated activation of FTO exacerbates impairment of the epithelial barrier by up-regulating IKBKB via N6-methyladenosine-dependent mRNA stability in asthmatic mice exposed to PM2.5.
    8. Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy.
      Title: Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy.
    9. FTO-mediated m6A modification of serum amyloid A2 mRNA promotes podocyte injury and inflammation by activating the NF-kappaB signaling pathway.
      Title: FTO-mediated m6A modification of serum amyloid A2 mRNA promotes podocyte injury and inflammation by activating the NF-κB signaling pathway.
    10. Disruption of CerS6-mediated sphingolipid metabolism by FTO deficiency aggravates ulcerative colitis.
      Title: Disruption of CerS6-mediated sphingolipid metabolism by FTO deficiency aggravates ulcerative colitis.
    Submit: New GeneRIF Correction See all GeneRIFs (102)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables broad specificity oxidative DNA demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables broad specificity oxidative DNA demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables broad specificity oxidative DNA demethylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA N6-methyladenosine dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA N6-methyladenosine dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidative RNA demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidative RNA demethylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA demethylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA alkylation repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA alkylation repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in RNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of eating behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of lipid storage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of respiratory system process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of white fat cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in temperature homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-ketoglutarate-dependent dioxygenase FTO
    Names
    U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
    U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
    fat mass and obesity associated
    fat mass and obesity-associated protein
    m6A(m)-demethylase FTO
    mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
    mRNA N(6)-methyladenosine demethylase FTO
    protein fatso
    tRNA N1-methyl adenine demethylase FTO
    NP_036066.2
    XP_006531099.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011936.2 → NP_036066.2  alpha-ketoglutarate-dependent dioxygenase FTO

      See identical proteins and their annotated locations for NP_036066.2

      Status: VALIDATED

      Source sequence(s)
      BC057008, BY290198, CA321822
      Consensus CDS
      CCDS22521.1
      UniProtKB/Swiss-Prot
      Q3TTZ5, Q6ZPI7, Q8BGW1, Q8BR68, Q8CB66, Q8R250, Q9QZ13
      Related
      ENSMUSP00000068380.8, ENSMUST00000069718.15
      Conserved Domains (2) summary
      pfam12933
      Location:36 → 322
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:326 → 495
      FTO_CTD; FTO C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      92039995..92395061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531036.2 → XP_006531099.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X1

      UniProtKB/TrEMBL
      E9Q1E4
      Conserved Domains (1) summary
      pfam12933
      Location:40 → 252
      FTO_NTD; FTO catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGW1.1 GenPept UniProtKB/Swiss-Prot:Q8BGW1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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