Plvap plasmalemma vesicle associated protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plvapprovided by MGI
Official Full Name: plasmalemma vesicle associated proteinprovided by MGI
Primary source: MGI:MGI:1890497
See related: Ensembl:ENSMUSG00000034845 AllianceGenome:MGI:1890497
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pv1; MECA32
Summary: Predicted to enable identical protein binding activity. Involved in developmental process and positive regulation of cellular extravasation. Predicted to be located in cell surface. Predicted to be integral component of membrane. Predicted to be active in caveola. Is expressed in several structures, including cardiovascular system; genitourinary system; liver; spleen; and trophectoderm. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human PLVAP (plasmalemma vesicle associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 563.9), adrenal adult (RPKM 272.0) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.43 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (71950397..71964446, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (71497753..71511806, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression analysis of plvap in mouse heart development, homeostasis and injury.
Title: Expression analysis of plvap in mouse heart development, homeostasis and injury.
A Potential New Role for Zinc in Age-Related Macular Degeneration through Regulation of Endothelial Fenestration.
Title: A Potential New Role for Zinc in Age-Related Macular Degeneration through Regulation of Endothelial Fenestration.
PV1 in Caveolae Controls Lung Endothelial Permeability.
Title: PV1 in Caveolae Controls Lung Endothelial Permeability.
Fenestral diaphragms and PLVAP associations in liver sinusoidal endothelial cells are developmentally regulated.
Title: Fenestral diaphragms and PLVAP associations in liver sinusoidal endothelial cells are developmentally regulated.
Retinal VEGFA maintains the ultrastructure and function of choriocapillaris by preserving the endothelial PLVAP.
Title: Retinal VEGFA maintains the ultrastructure and function of choriocapillaris by preserving the endothelial PLVAP.
These results show that Plvap expression in endothelial cells is important in the maintenance of IgM(+) B cells in the spleen and peritoneal cavity.
Title: Endothelial Plasmalemma Vesicle-Associated Protein Regulates the Homeostasis of Splenic Immature B Cells and B-1 B Cells.
an endothelium-specific molecule, plasmalemma vesicle-associated protein (PLVAP), regulates the seeding of fetal monocyte-derived macrophages to tissues in mice
Title: Fetal liver endothelium regulates the seeding of tissue-resident macrophages.
Results indicate that PLVAP is not only required for the formation of endothelial diaphragms, but also for the formation of endothelial fenestrae, even of those without diaphragms.
Title: Formation of fenestrae in murine liver sinusoids depends on plasmalemma vesicle-associated protein and is required for lipoprotein passage.
In the lymphatic sinus, PLVAP forms a physical sieve that regulates the parenchymal entry of lymphocytes and soluble antigens.
Title: The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes.
PV1 is involved in the tumor angiogenesis
Title: PV1 down-regulation via shRNA inhibits the growth of pancreatic adenocarcinoma xenografts.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Plvap (e-PCR), detects polymorphism
- UniSTS:226065

Plvap (e-PCR), detects polymorphism
- UniSTS:226066

AI607903 (e-PCR)
- UniSTS:179760

NoName (e-PCR)
- UniSTS:235922

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in developmental process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular extravasation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cellular extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular extravasation	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular permeability	IBA Inferred from Biological aspect of Ancestor more info
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
colocalizes_with caveola	ISO Inferred from Sequence Orthology more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: plasmalemma vesicle-associated protein

Names: MECA-32 antigen; plasmalemma vesicle protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032398.2 → NP_115774.2 plasmalemma vesicle-associated protein

See identical proteins and their annotated locations for NP_115774.2

Status: VALIDATED

Source sequence(s)

AC127416, AF348403, AI225679, AV003733, BM898788

Consensus CDS

CCDS22396.1

UniProtKB/Swiss-Prot

Q91VC4, Q99JB1

UniProtKB/TrEMBL

G3X924

Related

ENSMUSP00000035404.5, ENSMUST00000048452.6

Conserved Domains (1) summary

pfam06637
Location:1 → 436

PV-1; PV-1 protein (PLVAP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

71950397..71964446 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242342.3 → XP_011240644.1 plasmalemma vesicle-associated protein isoform X1

UniProtKB/Swiss-Prot

Q91VC4, Q99JB1

Conserved Domains (1) summary

pfam06637
Location:1 → 405

PV-1; PV-1 protein (PLVAP)