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    Mpzl1 myelin protein zero-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 68481, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Mpzl1provided by MGI
    Official Full Name
    myelin protein zero-like 1provided by MGI
    Primary source
    MGI:MGI:1915731
    See related
    Ensembl:ENSMUSG00000026566 AllianceGenome:MGI:1915731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PZR; 1110007A10Rik
    Summary
    Acts upstream of or within positive regulation of cell migration. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; alimentary system; hemolymphoid system gland; nervous system; and reproductive system. Orthologous to human MPZL1 (myelin protein zero like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 77.0), limb E14.5 (RPKM 61.2) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 H2.3; 1 72.94 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165419745..165462144, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165592176..165634541, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene adenylate cyclase 10 Neighboring gene predicted gene, 51751 Neighboring gene predicted gene, 51750 Neighboring gene STARR-positive B cell enhancer mm9_chr1:167509733-167510033 Neighboring gene STARR-positive B cell enhancer ABC_E11103 Neighboring gene STARR-positive B cell enhancer ABC_E4372 Neighboring gene STARR-positive B cell enhancer ABC_E324 Neighboring gene STARR-positive B cell enhancer ABC_E1570 Neighboring gene nuclear encoded tRNA proline 2 (anticodon AGG) Neighboring gene nuclear encoded tRNA proline 2 (anticodon CGG)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PZR promotes tumorigenicity of lung cancer cells by regulating cell migration and invasion via modulating oxidative stress and cell adhesion. Fu Y, et al. Aging (Albany NY), 2023 Jun 6. PMID 37279992, Free PMC Article
    2. Tyrosyl phosphorylation of PZR promotes hypertrophic cardiomyopathy in PTPN11-associated Noonan syndrome with multiple lentigines. Yi JS, et al. JCI Insight, 2020 Aug 6. PMID 32584792, Free PMC Article
    3. Loss of Mpzl3 function causes various skin abnormalities and greatly reduced adipose depots. Leiva AG, et al. J Invest Dermatol, 2014 Jul. PMID 24531688, Free PMC Article
    4. The murine ortholog of the SHP-2 binding molecule, PZR accelerates cell migration on fibronectin and is expressed in early embryo formation. Roubelakis MG, et al. J Cell Biochem, 2007 Nov 1. PMID 17440960
    5. Noonan syndrome-associated SHP-2/Ptpn11 mutants enhance SIRPalpha and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation. Eminaga S, et al. J Biol Chem, 2008 May 30. PMID 18378677, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PZR promotes tumorigenicity of lung cancer cells by regulating cell migration and invasion via modulating oxidative stress and cell adhesion.
      Title: PZR promotes tumorigenicity of lung cancer cells by regulating cell migration and invasion via modulating oxidative stress and cell adhesion.
    2. Tyrosyl phosphorylation of PZR promotes hypertrophic cardiomyopathy in PTPN11-associated Noonan syndrome with multiple lentigines.
      Title: Tyrosyl phosphorylation of PZR promotes hypertrophic cardiomyopathy in PTPN11-associated Noonan syndrome with multiple lentigines.
    3. These data reveal a complex role for Mpzl3 in the control of skin development, hair growth, and adipose cell functions.
      Title: Loss of Mpzl3 function causes various skin abnormalities and greatly reduced adipose depots.
    4. Phosphorylation and localization of PZR in cultufred endothelial cells is reported.
      Title: Phosphorylation and localization of protein-zero related (PZR) in cultured endothelial cells.
    5. SIRPalpha and PZR serve as scaffolds that facilitate plasma membrane recruitment and signaling of NS-associated SHP-2 mutants.
      Title: Noonan syndrome-associated SHP-2/Ptpn11 mutants enhance SIRPalpha and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation.
    6. describe the function of the mPZR isoforms in vivo, particularly with respect to their roles in regulating SHP-2-dependent cell migration during development.
      Title: The murine ortholog of the SHP-2 binding molecule, PZR accelerates cell migration on fibronectin and is expressed in early embryo formation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myelin protein zero-like protein 1
    Names
    protein zero-related

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001880.2 → NP_001001880.1  myelin protein zero-like protein 1 isoform b precursor

      See identical proteins and their annotated locations for NP_001001880.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, compared to variant 1, that causes a frameshift. The resulting protein (isoform b) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      BB871672, BC072563, CX210059
      Consensus CDS
      CCDS35758.1
      UniProtKB/TrEMBL
      A0A0A6YW22, A0A0R4J0V2
      Related
      ENSMUSP00000070343.8, ENSMUST00000068705.13
      Conserved Domains (2) summary
      cd05715
      Location:39 → 154
      Ig_P0-like; Immunoglobulin (Ig)-like domain of Protein zero (P0) and similar proteins
      smart00410
      Location:43 → 154
      IG_like; Immunoglobulin like

    2. NM_001083897.1 → NP_001077366.1  myelin protein zero-like protein 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001077366.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK169385, BB871672, CX210059
      Consensus CDS
      CCDS35757.1
      UniProtKB/Swiss-Prot
      Q2VW02, Q3TEW6, Q6GQX5
      UniProtKB/TrEMBL
      A0A0A6YWA2
      Related
      ENSMUSP00000107062.3, ENSMUST00000111435.9
      Conserved Domains (2) summary
      cd00096
      Location:38 → 42
      Ig; Ig strand A [structural motif]
      cl11960
      Location:38 → 154
      Ig; Immunoglobulin domain

    3. NM_001347128.1 → NP_001334057.1  myelin protein zero-like protein 1 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC102776
      Consensus CDS
      CCDS83623.1
      UniProtKB/TrEMBL
      A0A0A6YXW1
      Related
      ENSMUSP00000142164.2, ENSMUST00000194437.6
      Conserved Domains (1) summary
      cl11960
      Location:39 → 86
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      165419745..165462144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004934160.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TEW6.1 GenPept UniProtKB/Swiss-Prot:Q3TEW6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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