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    Snx10 sorting nexin 10 [ Mus musculus (house mouse) ]

    Gene ID: 71982, updated on 2-May-2024

    Summary

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    Official Symbol
    Snx10provided by MGI
    Official Full Name
    sorting nexin 10provided by MGI
    Primary source
    MGI:MGI:1919232
    See related
    Ensembl:ENSMUSG00000038301 AllianceGenome:MGI:1919232
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410004M09Rik
    Summary
    Predicted to enable 1-phosphatidylinositol binding activity and ATPase binding activity. Involved in osteoclast differentiation. Acts upstream of or within several processes, including bone mineralization involved in bone maturation; bone resorption; and cellular response to leukemia inhibitory factor. Located in several cellular components, including apical cytoplasm; endoplasmic reticulum; and secretory granule. Is expressed in forelimb and humerus cartilage condensation. Used to study autosomal recessive osteopetrosis 8. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 8. Orthologous to human SNX10 (sorting nexin 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 11.5), cortex adult (RPKM 10.9) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snx10 in Genome Data Viewer
    Location:
    6 B3; 6 24.95 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (51500882..51567659)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (51523900..51590679)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15871 Neighboring gene STARR-seq mESC enhancer starr_15873 Neighboring gene nuclear factor, erythroid derived 2, like 3 Neighboring gene heterogeneous nuclear ribonucleoprotein A2/B1 Neighboring gene STARR-seq mESC enhancer starr_15875 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:51459345-51459528 Neighboring gene STARR-seq mESC enhancer starr_15881 Neighboring gene chromobox 3 Neighboring gene predicted gene, 52883 Neighboring gene predicted gene, 53331 Neighboring gene STARR-seq mESC enhancer starr_15887 Neighboring gene STARR-seq mESC enhancer starr_15888 Neighboring gene STARR-positive B cell enhancer mm9_chr6:51663532-51663833 Neighboring gene predicted gene, 38811 Neighboring gene STARR-seq mESC enhancer starr_15891 Neighboring gene VISTA enhancer mm412 Neighboring gene src family associated phosphoprotein 2 Neighboring gene STARR-seq mESC enhancer starr_15896 Neighboring gene STARR-seq mESC enhancer starr_15897

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation. Bao W, et al. Pharmacol Res, 2021 Jul. PMID 34010669
    2. An SNX10-dependent mechanism downregulates fusion between mature osteoclasts. Barnea-Zohar M, et al. J Cell Sci, 2021 May 1. PMID 33975343, Free PMC Article
    3. Massive osteopetrosis caused by non-functional osteoclasts in R51Q SNX10 mutant mice. Stein M, et al. Bone, 2020 Jul. PMID 32278070
    4. SNX10 mediates alcohol-induced liver injury and steatosis by regulating the activation of chaperone-mediated autophagy. You Y, et al. J Hepatol, 2018 Jul. PMID 29452206
    5. SNX10 promotes phagosome maturation in macrophages and protects mice against Listeria monocytogenes infection. Lou J, et al. Oncotarget, 2017 Aug 15. PMID 28903313, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SNX10 promoted liver IR injury by facilitating macrophage M1 polarization via NLRP3 inflammasome activation.
      Title: SNX10 promoted liver IR injury by facilitating macrophage M1 polarization via NLRP3 inflammasome activation.
    2. Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells.
      Title: Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells.
    3. Long noncoding RNA H19 synergizes with STAT1 to regulate SNX10 in rheumatoid arthritis.
      Title: Long noncoding RNA H19 synergizes with STAT1 to regulate SNX10 in rheumatoid arthritis.
    4. Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation.
      Title: Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation.
    5. An SNX10-dependent mechanism downregulates fusion between mature osteoclasts.
      Title: An SNX10-dependent mechanism downregulates fusion between mature osteoclasts.
    6. Snx10 and PIKfyve are required for lysosome formation in osteoclasts.
      Title: Snx10 and PIKfyve are required for lysosome formation in osteoclasts.
    7. Massive osteopetrosis caused by non-functional osteoclasts in R51Q SNX10 mutant mice.
      Title: Massive osteopetrosis caused by non-functional osteoclasts in R51Q SNX10 mutant mice.
    8. SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC.
      Title: SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC.
    9. FKBP12: A partner of Snx10 required for vesicular trafficking in osteoclasts.
      Title: FKBP12: A partner of Snx10 required for vesicular trafficking in osteoclasts.
    10. this work revealed that SNX10 controls mTOR activation through regulating chaperone-mediated autophagy-dependent amino-acid metabolism.
      Title: Sorting nexin 10 controls mTOR activation through regulating amino-acid metabolism in colorectal cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone mineralization involved in bone maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular homeostasis IC
    Inferred by Curator
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gastric acid secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ruffle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tooth eruption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extrinsic component of endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sorting nexin-10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127348.1 → NP_001120820.1  sorting nexin-10 isoform a

      See identical proteins and their annotated locations for NP_001120820.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
      Source sequence(s)
      AK028163, AK150878, AK151320, AK166121
      Consensus CDS
      CCDS20136.1
      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Related
      ENSMUSP00000136974.2, ENSMUST00000179365.8
      Conserved Domains (1) summary
      cd06898
      Location:12 → 109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

    2. NM_001127349.1 → NP_001120821.1  sorting nexin-10 isoform a

      See identical proteins and their annotated locations for NP_001120821.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
      Source sequence(s)
      AK150878, AK151320
      Consensus CDS
      CCDS20136.1
      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Related
      ENSMUSP00000044165.9, ENSMUST00000049152.15
      Conserved Domains (1) summary
      cd06898
      Location:12 → 109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

    3. NM_001361576.1 → NP_001348505.1  sorting nexin-10 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longer isoform (a). Variants 1-9 all encode the same isoform (a).
      Source sequence(s)
      AC153877
      Consensus CDS
      CCDS20136.1
      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Related
      ENSMUSP00000117914.2, ENSMUST00000137212.8
      Conserved Domains (1) summary
      cd06898
      Location:12 → 109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

    4. NM_001361577.1 → NP_001348506.1  sorting nexin-10 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
      Source sequence(s)
      AC153877
      Consensus CDS
      CCDS20136.1
      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Conserved Domains (1) summary
      cd06898
      Location:12 → 109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

    5. NM_001361578.1 → NP_001348507.1  sorting nexin-10 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
      Source sequence(s)
      AC153877
      Consensus CDS
      CCDS20136.1
      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Conserved Domains (1) summary
      cd06898
      Location:12 → 109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

    6. NM_001361579.1 → NP_001348508.1  sorting nexin-10 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
      Source sequence(s)
      AC153877
      Consensus CDS
      CCDS20136.1
      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Conserved Domains (1) summary
      cd06898
      Location:12 → 109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

    7. NM_001361580.1 → NP_001348509.1  sorting nexin-10 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
      Source sequence(s)
      AC153877
      Consensus CDS
      CCDS20136.1
      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Conserved Domains (1) summary
      cd06898
      Location:12 → 109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

    8. NM_001361581.1 → NP_001348510.1  sorting nexin-10 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
      Source sequence(s)
      AC153877
      Consensus CDS
      CCDS20136.1
      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Conserved Domains (1) summary
      cd06898
      Location:12 → 109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

    9. NM_001361582.1 → NP_001348511.1  sorting nexin-10 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC153877
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7
      Conserved Domains (1) summary
      cl02563
      Location:1 → 69
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    10. NM_028035.4 → NP_082311.3  sorting nexin-10 isoform a

      See identical proteins and their annotated locations for NP_082311.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
      Source sequence(s)
      AK028163, AK150878, AK151320
      Consensus CDS
      CCDS20136.1
      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Related
      ENSMUSP00000110082.2, ENSMUST00000114439.8
      Conserved Domains (1) summary
      cd06898
      Location:12 → 109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      51500882..51567659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255600.2 → XP_030111460.1  sorting nexin-10 isoform X1

      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Conserved Domains (1) summary
      cd06898
      Location:12 → 109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

    2. XM_036152314.1 → XP_036008207.1  sorting nexin-10 isoform X2

      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7
      Conserved Domains (1) summary
      cl02563
      Location:1 → 69
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    3. XM_036152316.1 → XP_036008209.1  sorting nexin-10 isoform X2

      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7
      Conserved Domains (1) summary
      cl02563
      Location:1 → 69
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    4. XM_011241474.1 → XP_011239776.1  sorting nexin-10 isoform X2

      See identical proteins and their annotated locations for XP_011239776.1

      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7
      Conserved Domains (1) summary
      cl02563
      Location:1 → 69
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWT3.1 GenPept UniProtKB/Swiss-Prot:Q9CWT3

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