Pdxk pyridoxal (pyridoxine, vitamin B6) kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdxkprovided by MGI
Official Full Name: pyridoxal (pyridoxine, vitamin B6) kinaseprovided by MGI
Primary source: MGI:MGI:1351869
See related: Ensembl:ENSMUSG00000032788 AllianceGenome:MGI:1351869
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310036D04Rik
Summary: Predicted to enable several functions, including anion binding activity; cation binding activity; and protein homodimerization activity. Predicted to be involved in negative regulation of apoptotic process and pyridoxal 5'-phosphate salvage. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human PDXK (pyridoxal kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 41.8), kidney adult (RPKM 40.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (78272581..78300782, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (78436747..78464948, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pdxk (e-PCR), detects polymorphism
- UniSTS:259127

NoName (e-PCR)
- UniSTS:236387

RH126288 (e-PCR)
- UniSTS:162996

AU015827 (e-PCR)
- UniSTS:208569

D10Jhu33 (e-PCR), detects polymorphism
- UniSTS:158689

D10Jhu38 (e-PCR), detects polymorphism
- UniSTS:158694

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables lithium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables organic cyclic compound binding	ISO Inferred from Sequence Orthology more info
enables phosphotransferase activity, alcohol group as acceptor	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphotransferase activity, alcohol group as acceptor	ISO Inferred from Sequence Orthology more info	PubMed
enables potassium ion binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables pyridoxal binding	ISO Inferred from Sequence Orthology more info
enables pyridoxal kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal kinase activity	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	ISO Inferred from Sequence Orthology more info
enables small molecule binding	ISO Inferred from Sequence Orthology more info
enables sodium ion binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in pyridoxal 5'-phosphate salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyridoxal 5'-phosphate salvage	ISO Inferred from Sequence Orthology more info
involved_in pyridoxal metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in pyridoxal phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in pyridoxal phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in pyridoxal phosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyridoxal phosphate metabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in pyridoxamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyridoxine metabolic process	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pyridoxal kinase

Names: pyridoxine kinase

NP_742146.1

EC 2.7.1.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172134.2 → NP_742146.1 pyridoxal kinase

See identical proteins and their annotated locations for NP_742146.1

Status: VALIDATED

Source sequence(s)

BC027745, BC032171, BI143426

Consensus CDS

CCDS23965.1

UniProtKB/Swiss-Prot

Q3TM83, Q8BJQ5, Q8K183

Related

ENSMUSP00000038540.9, ENSMUST00000041616.15

Conserved Domains (1) summary

cl00192
Location:6 → 304

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...