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    Pgam5 phosphoglycerate mutase family member 5 [ Mus musculus (house mouse) ]

    Gene ID: 72542, updated on 12-May-2024

    Summary

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    Official Symbol
    Pgam5provided by MGI
    Official Full Name
    phosphoglycerate mutase family member 5provided by MGI
    Primary source
    MGI:MGI:1919792
    See related
    Ensembl:ENSMUSG00000029500 AllianceGenome:MGI:1919792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610528A17Rik
    Summary
    Predicted to enable GTPase activator activity and protein serine/threonine phosphatase activity. Involved in necroptotic process and negative regulation of cold-induced thermogenesis. Predicted to be located in mitochondrial outer membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Orthologous to human PGAM5 (PGAM family member 5, mitochondrial serine/threonine protein phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 16.9), CNS E18 (RPKM 16.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pgam5 in Genome Data Viewer
    Location:
    5 F; 5 53.43 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110407001..110417765, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110259135..110269899, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene golgin A3 Neighboring gene uncharacterized LOC118568795 Neighboring gene STARR-seq mESC enhancer starr_13947 Neighboring gene ankyrin repeat and LEM domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_13949 Neighboring gene STARR-positive B cell enhancer ABC_E6363 Neighboring gene peroxisomal membrane protein 2 Neighboring gene polymerase (DNA directed), epsilon Neighboring gene predicted gene, 26277

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phosphoglycerate mutase 5 facilitates mitochondrial dysfunction and neuroinflammation in spinal tissues after spinal cord injury. Dai C, et al. Int Immunopharmacol, 2023 Mar. PMID 36773566
    2. Phosphoglycerate mutase 5 initiates inflammation in acute kidney injury by triggering mitochondrial DNA release by dephosphorylating the pro-apoptotic protein Bax. Li J, et al. Kidney Int, 2023 Jan. PMID 36089186
    3. Phosphoglycerate mutase 5 exacerbates cardiac ischemia-reperfusion injury through disrupting mitochondrial quality control. Zhu H, et al. Redox Biol, 2021 Jan. PMID 33166869, Free PMC Article
    4. Butylphthalide ameliorates experimental autoimmune encephalomyelitis by suppressing PGAM5-induced necroptosis and inflammation in microglia. Wang Y, et al. Biochem Biophys Res Commun, 2018 Feb 26. PMID 29407174
    5. PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury. He GW, et al. Gut, 2017 Apr. PMID 27566130

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphoglycerate mutase 5 exacerbates liver ischemia-reperfusion injury by activating mitochondrial fission.
      Title: Phosphoglycerate mutase 5 exacerbates liver ischemia-reperfusion injury by activating mitochondrial fission.
    2. Phosphoglycerate mutase 5 aggravates alcoholic liver disease through disrupting VDAC-1-dependent mitochondrial integrity.
      Title: Phosphoglycerate mutase 5 aggravates alcoholic liver disease through disrupting VDAC-1-dependent mitochondrial integrity.
    3. Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis.
      Title: Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis.
    4. PGAM5 knockout causes depressive-like behaviors in mice via ATP deficiency in the prefrontal cortex.
      Title: PGAM5 knockout causes depressive-like behaviors in mice via ATP deficiency in the prefrontal cortex.
    5. Pgam5-mediated PHB2 dephosphorylation contributes to endotoxemia-induced myocardial dysfunction by inhibiting mitophagy and the mitochondrial unfolded protein response.
      Title: Pgam5-mediated PHB2 dephosphorylation contributes to endotoxemia-induced myocardial dysfunction by inhibiting mitophagy and the mitochondrial unfolded protein response.
    6. Phosphoglycerate mutase 5 facilitates mitochondrial dysfunction and neuroinflammation in spinal tissues after spinal cord injury.
      Title: Phosphoglycerate mutase 5 facilitates mitochondrial dysfunction and neuroinflammation in spinal tissues after spinal cord injury.
    7. Phosphoglycerate mutase 5 initiates inflammation in acute kidney injury by triggering mitochondrial DNA release by dephosphorylating the pro-apoptotic protein Bax.
      Title: Phosphoglycerate mutase 5 initiates inflammation in acute kidney injury by triggering mitochondrial DNA release by dephosphorylating the pro-apoptotic protein Bax.
    8. E3 ubiquitin ligase ring finger protein 5 protects against hepatic ischemia reperfusion injury by mediating phosphoglycerate mutase family member 5 ubiquitination.
      Title: E3 ubiquitin ligase ring finger protein 5 protects against hepatic ischemia reperfusion injury by mediating phosphoglycerate mutase family member 5 ubiquitination.
    9. NR4A1 Promotes LPS-Induced Acute Lung Injury through Inhibition of Opa1-Mediated Mitochondrial Fusion and Activation of PGAM5-Related Necroptosis.
      Title: NR4A1 Promotes LPS-Induced Acute Lung Injury through Inhibition of Opa1-Mediated Mitochondrial Fusion and Activation of PGAM5-Related Necroptosis.
    10. Phosphoglycerate Mutase 5 Knockdown Alleviates Neuronal Injury After Traumatic Brain Injury Through Drp1-Mediated Mitochondrial Dysfunction.
      Title: Phosphoglycerate Mutase 5 Knockdown Alleviates Neuronal Injury After Traumatic Brain Injury Through Drp1-Mediated Mitochondrial Dysfunction.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in necroptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in necroptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-threonine dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase PGAM5, mitochondrial
    NP_001157010.1
    NP_082549.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163538.1 → NP_001157010.1  serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_001157010.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC052179, BY101410, BY620990
      Consensus CDS
      CCDS51606.1
      UniProtKB/Swiss-Prot
      B2RSM6, Q3UK19, Q80VY8, Q8BM78, Q8BX10, Q9CZU2
      UniProtKB/TrEMBL
      B7ZNW0
      Related
      ENSMUSP00000108124.3, ENSMUST00000112505.9
      Conserved Domains (1) summary
      cd07067
      Location:98 → 271
      HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    2. NM_028273.3 → NP_082549.2  serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_082549.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, which results in a protein (isoform 2) which is 1 amino acid shorter than isoform 1.
      Source sequence(s)
      AK034588, BC138925, BY101410, BY620990
      Consensus CDS
      CCDS19523.1
      UniProtKB/TrEMBL
      B7ZNW0
      Related
      ENSMUSP00000057760.9, ENSMUST00000059229.16
      Conserved Domains (1) summary
      cd07067
      Location:98 → 270
      HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      110407001..110417765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BX10.1 GenPept UniProtKB/Swiss-Prot:Q8BX10

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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