MAP1B microtubule associated protein 1B [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAP1Bprovided by HGNC
Official Full Name: microtubule associated protein 1Bprovided by HGNC
Primary source: HGNC:HGNC:6836
See related: Ensembl:ENSG00000131711 MIM:157129; AllianceGenome:HGNC:6836
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MAP5; PVNH9; DFNA83; FUTSCH; PPP1R102
Summary: This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 49.2), adrenal (RPKM 7.7) and 10 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q13.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (72107475..72209565)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (72588652..72690733)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (71403302..71505392)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and tumorigenesis.
Title: A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and tumorigenesis.
Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviors via autophagy pathway.
Title: Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviors via autophagy pathway.
The miR-223-3p/MAP1B axis aggravates TGF-beta-induced proliferation and migration of BPH-1 cells.
Title: The miR-223-3p/MAP1B axis aggravates TGF-β-induced proliferation and migration of BPH-1 cells.
Epilepsy phenotypes associated with MAP1B-related brain malformations.
Title: Epilepsy phenotypes associated with MAP1B-related brain malformations.
Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss.
Title: Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss.
These neuritic defects result from impaired Nrf2 activity on antioxidant response elements (AREs) localized to a microtubule-associated protein (Map1b) gene enhancer and are rescued by forced expression of Map1b as well as by both Nrf2 overexpression and pharmaceutical activation in Parkinson's disease (PD) neurons
Title: Axonal pathology in hPSC-based models of Parkinson's disease results from loss of Nrf2 transcriptional activity at the Map1b gene locus.
Knockdown of microtubule-associated protein 1B light chain (MAP 1B-LC1) represses E-cadherin downregulation, vimentin upregulation and actin filament remodeling, decreases cell migration and invasion during TGF-beta1-induced epithelial to mesenchymal transition (EMT) in A549 cells. Heterogeneous nuclear ribonucleoprotein K (hnRNP K) promotes the EMT of lung cancer cells induced by TGF-beta1 through interacting with MAP...
Title: Interaction of hnRNP K with MAP 1B-LC1 promotes TGF-β1-mediated epithelial to mesenchymal transition in lung cancer cells.
Calpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B
Title: Calpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B.
MAP1B-LC1 links microtubules and Stx17 in fed cells, and starvation causes the dephosphorylation of MAP1B-LC1 at Thr217, allowing Stx17 to dissociate from MAP1B-LC1 and bind to Atg14L.
Title: MAP1B-LC1 prevents autophagosome formation by linking syntaxin 17 to microtubules.
High MAP1B expression is associated with resistance to mTOR inhibition in glioblastoma.
Title: A molecular cascade modulates MAP1B and confers resistance to mTOR inhibition in human glioblastoma.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Hearing loss, autosomal dominant 83 MedGen: C5676951 OMIM: 619808 GeneReviews: Not available	not available
Periventricular nodular heterotopia 9 MedGen: C5394503 OMIM: 618918 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	HIV-1 Vif interacts with MAP1B; interaction predicted to be relevant to proteolysis	PubMed
	vif	HIV-1 Vif downregulates the expression of microtubule-associated protein 1B (MAP1B) in Vif-expression T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5S2382 (e-PCR)
- UniSTS:40193

AFMB332XE9 (e-PCR)
- UniSTS:36868

D5S1639E (e-PCR)
- UniSTS:3848

SHGC-153845 (e-PCR)
- UniSTS:177953

D5S572E (e-PCR)
- UniSTS:473124

RH78085 (e-PCR)
- UniSTS:44332

G10477 (e-PCR)
- UniSTS:72751

FB10E8 (e-PCR)
- UniSTS:65076

X51396 (e-PCR)
- UniSTS:160337

WI-19293 (e-PCR)
- UniSTS:25204

WI-16218 (e-PCR)
- UniSTS:58750

RH12515 (e-PCR)
- UniSTS:10893

GDB:194651 (e-PCR)
- UniSTS:155796

D5S451E (e-PCR)
- UniSTS:147364

D5S522E (e-PCR)
- UniSTS:473008

D5S1491 (e-PCR)
- UniSTS:44259

RH119882 (e-PCR)
- UniSTS:133627

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule binding	TAS Traceable Author Statement more info	PubMed
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables structural molecule activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in axon extension	TAS Traceable Author Statement more info	PubMed
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to peptide hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in dendrite development	IBA Inferred from Biological aspect of Ancestor more info
involved_in developmental maturation	IEA Inferred from Electronic Annotation more info
involved_in establishment of monopolar cell polarity	IEA Inferred from Electronic Annotation more info
involved_in induction of synaptic plasticity by chemical substance	IEA Inferred from Electronic Annotation more info
involved_in microtubule bundle formation	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion transport along microtubule	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intracellular transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of microtubule depolymerization	IEA Inferred from Electronic Annotation more info
involved_in neuron migration	TAS Traceable Author Statement more info	PubMed
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within odontoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in peripheral nervous system axon regeneration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of axon extension	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of microtubule polymerization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to carbohydrate	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to inorganic substance	IEA Inferred from Electronic Annotation more info
involved_in response to insecticide	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to vitamin A	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in synapse assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in basal dendrite	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in hippocampal mossy fiber	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	ISS Inferred from Sequence or Structural Similarity more info
part_of microtubule associated complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in photoreceptor outer segment	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in somatodendritic compartment	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in varicosity	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: microtubule-associated protein 1B

Names: protein phosphatase 1, regulatory subunit 102

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001324255.2 → NP_001311184.1 microtubule-associated protein 1B isoform 2

Status: VALIDATED

Source sequence(s)

AK125194, AK307990, BC046114, BC073993, BN001085, HY119868

UniProtKB/TrEMBL

A2BDK6

Conserved Domains (1) summary

PRK14949
Location:1405 → 1703

PRK14949; DNA polymerase III subunits gamma and tau; Provisional
NM_005909.5 → NP_005900.2 microtubule-associated protein 1B isoform 1

See identical proteins and their annotated locations for NP_005900.2

Status: VALIDATED

Source sequence(s)

AC012609, BC017240, BC046114, BN001084, CA429544

Consensus CDS

CCDS4012.1

UniProtKB/Swiss-Prot

A2BDK5, P46821

UniProtKB/TrEMBL

A2BDK6

Related

ENSP00000296755.7, ENST00000296755.12

Conserved Domains (1) summary

PRK14949
Location:1531 → 1829

PRK14949; DNA polymerase III subunits gamma and tau; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

72107475..72209565

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

72588652..72690733

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_032010.1: Suppressed sequence

Description

NM_032010.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.