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    YLR345W bifunctional fructose-2,6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851059, updated on 17-May-2024

    Summary

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    Gene symbol
    YLR345W
    Gene description
    bifunctional fructose-2,6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase
    Primary source
    FungiDB:YLR345W
    Locus tag
    YLR345W
    See related
    SGD:S000004337; AllianceGenome:SGD:S000004337; VEuPathDB:YLR345W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Located in cytoplasm. Orthologous to several human genes including PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1); PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2); and PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YLR345W in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (820511..822040)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene tRNA-Arg Neighboring gene ribosomal 60S subunit protein L26A Neighboring gene Cis1p Neighboring gene karyopherin beta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of new genes regulated by the Crt1 transcription factor, an effector of the DNA damage checkpoint pathway in Saccharomyces cerevisiae. Zaim J, et al. J Biol Chem, 2005 Jan 7. PMID 15494396
    2. Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Lin YY, et al. Cell, 2009 Mar 20. PMID 19303850, Free PMC Article
    3. Genetic interaction network of the Saccharomyces cerevisiae type 1 phosphatase Glc7. Logan MR, et al. BMC Genomics, 2008 Jul 15. PMID 18627629, Free PMC Article
    4. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549
    5. A role for the budding yeast separase, Esp1, in Ty1 element retrotransposition. Ho KL, et al. PLoS Genet, 2015 Mar. PMID 25822502, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 6-phosphofructo-2-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6-phosphofructo-2-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 6-phosphofructo-2-kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructose-2,6-bisphosphate 2-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose-2,6-bisphosphate 2-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose 2,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 2,6-bisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose 2,6-bisphosphate metabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of glycolytic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional fructose-2,6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase
    NP_013449.1
    • Similar to 6-phosphofructo-2-kinase enzymes; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      820511..822040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182234.1 → NP_013449.1  TPA: bifunctional fructose-2,6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013449.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYY4, Q06137
      UniProtKB/TrEMBL
      A0A8H4FA64, B3RHL5, B5VNN7, C8ZDV2, N1NYN3
      Conserved Domains (2) summary
      COG0406
      Location:290 → 505
      PhoE; Broad specificity phosphatase PhoE [Carbohydrate transport and metabolism]
      pfam01591
      Location:71 → 291
      6PF2K; 6-phosphofructo-2-kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06137.1

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