U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SME1 mRNA splicing protein SME1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854330, updated on 17-May-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    SME1
    Gene description
    mRNA splicing protein SME1
    Primary source
    FungiDB:YOR159C
    Locus tag
    YOR159C
    See related
    SGD:S000005685; AllianceGenome:SGD:S000005685; VEuPathDB:YOR159C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables splicing factor binding activity. Involved in mRNA splicing, via spliceosome. Part of U2-type prespliceosome and spliceosomal snRNP complex. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; hypotrichosis 1; hypotrichosis 11; and lupus nephritis. Orthologous to human SNRPE (small nuclear ribonucleoprotein polypeptide E). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SME1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (633282..633566, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene proteasome core particle subunit beta 2 Neighboring gene mitochondrial 37S ribosomal protein PET123 Neighboring gene Mtr10p Neighboring gene Pns1p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The yeast SME1 gene encodes the homologue of the human E core protein. Bordonné R, et al. Gene, 1996 Oct 17. PMID 8918241
    2. Analysis of a 35.6 kb region on the right arm of Saccharomyces cerevisiae chromosome XV. Bordonné R, et al. Yeast, 1997 Jan. PMID 9046089
    3. Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae. Lee JW, et al. Sci Rep, 2021 Dec 17. PMID 34921163, Free PMC Article
    4. Homomeric ring assemblies of eukaryotic Sm proteins have affinity for both RNA and DNA. Crystal structure of an oligomeric complex of yeast SmF. Collins BM, et al. J Biol Chem, 2003 May 9. PMID 12618433
    5. The yeast splicing factor Prp40p contains functional leucine-rich nuclear export signals that are essential for splicing. Murphy MW, et al. Genetics, 2004 Jan. PMID 15020406, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae.
      Title: Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables splicing factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U4 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pICln-Sm protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    mRNA splicing protein SME1
    NP_014802.3
    • Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      633282..633566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183578.3 → NP_014802.3  TPA: mRNA splicing protein SME1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014802.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2L6, Q12330
      UniProtKB/TrEMBL
      A0A6A5Q895, A6ZP03, B3LJJ1, C7GN66, C8ZGR7, G2WN31, N1NVT5
      Conserved Domains (1) summary
      cd01718
      Location:7 → 92
      Sm_E; Sm protein E
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    3JCM_V.1
    3JCM_Y.1
    5GM6_i.1
    5GMK_i.1
    5GMK_u.1
    5WSG_G.1
    5WSG_i.1
    5Y88_b.1
    5Y88_i.1
    5YLZ_b.1
    5YLZ_i.1
    5ZWM_T.1
    5ZWM_e.1
    5ZWM_i.1
    5ZWN_e.1
    5ZWO_T.1
    5ZWO_e.1
    5ZWO_i.1
    6BK8_c.1
    6BK8_l.1
    6EXN_e.1
    6EXN_p.1
    6J6G_i.1
    6J6G_u.1
    6J6H_i.1
    6J6H_u.1
    6J6N_i.1
    6J6N_u.1
    6J6Q_i.1
    6J6Q_u.1
    6N7P_O.1
    6N7R_O.1
    6N7X_O.1
    Q12330.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools