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    SMP3 glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854320, updated on 17-May-2024

    Summary

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    Gene symbol
    SMP3
    Gene description
    glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase
    Primary source
    FungiDB:YOR149C
    Locus tag
    YOR149C
    See related
    SGD:S000005675; AllianceGenome:SGD:S000005675; VEuPathDB:YOR149C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LAS2; SAP2
    Summary
    Enables alpha-1,2-mannosyltransferase activity. Involved in GPI anchor biosynthetic process and plasmid maintenance. Located in endoplasmic reticulum. Used to study cancer. Orthologous to human PIGZ (phosphatidylinositol glycan anchor biosynthesis class Z). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SMP3 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (609838..611388, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Mdm32p Neighboring gene Spp2p Neighboring gene mitochondrial 54S ribosomal protein YmL23 Neighboring gene DNA-directed RNA polymerase II core subunit RPB2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in a Saccharomyces cerevisiae host showing increased holding stability of the heterologous plasmid pSR1. Irie K, et al. Mol Gen Genet, 1991 Feb. PMID 2005867
    2. Analysis of a 35.6 kb region on the right arm of Saccharomyces cerevisiae chromosome XV. Bordonné R, et al. Yeast, 1997 Jan. PMID 9046089
    3. A gene, SMP2, involved in plasmid maintenance and respiration in Saccharomyces cerevisiae encodes a highly charged protein. Irie K, et al. Mol Gen Genet, 1993 Jan. PMID 8437575
    4. Ynl038wp (Gpi15p) is the Saccharomyces cerevisiae homologue of human Pig-Hp and participates in the first step in glycosylphosphatidylinositol assembly. Yan BC, et al. Yeast, 2001 Nov. PMID 11746600
    5. LAS1 is an essential nuclear protein involved in cell morphogenesis and cell surface growth. Doseff AI, et al. Genetics, 1995 Nov. PMID 8582632, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,2-mannosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate derivative biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in plasmid maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase
    NP_014792.4
    • Alpha 1,2-mannosyltransferase; involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      609838..611388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183568.4 → NP_014792.4  TPA: glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014792.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2K6, Q04174, Q99400
      UniProtKB/TrEMBL
      A0A8H4F8T3, A6ZNZ3, B5VS35, C7GN75, C8ZGQ7, G2WN21, N1NWN3
      Conserved Domains (1) summary
      pfam03901
      Location:6 → 400
      Glyco_transf_22; Alg9-like mannosyltransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04174.3

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