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    pfk1 putative 6-phosphofructokinase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539972, updated on 7-Apr-2024

    Summary

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    Gene symbol
    pfk1
    Gene description
    putative 6-phosphofructokinase
    Primary source
    PomBase:SPBC16H5.02
    Locus tag
    SPBC16H5.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2297164..2300512, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene putative cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp7 Neighboring gene putative pho88 family protein Neighboring gene putative SUMO E1-like activator enzyme Fub2 Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene protein Sad1 Neighboring gene DNA polymerase delta subunit Cdm1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structures of S. pombe phosphofructokinase in the F6P-bound and ATP-bound states. Benjamin S, et al. J Struct Biol, 2007 Sep. PMID 17643314, Free PMC Article
    2. Purification, molecular and kinetic characterization of phosphofructokinase-1 from the yeast Schizosaccharomyces pombe: evidence for an unusual subunit composition. Reuter R, et al. Yeast, 2000 Oct. PMID 11015725
    3. The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2. Jongjitwimol J, et al. PLoS One, 2014. PMID 24818994, Free PMC Article
    4. A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast. Mathiassen SG, et al. J Biol Chem, 2015 Aug 21. PMID 26152728, Free PMC Article
    5. Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis. Snaith HA, et al. J Cell Sci, 2011 Jul 1. PMID 21652630, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 6-phosphofructokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6-phosphofructokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables AMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fructose-6-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose-6-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical glycolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 1,6-bisphosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fructose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 6-phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycolytic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of 6-phosphofructokinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of 6-phosphofructokinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytoplasmic side of mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative 6-phosphofructokinase
    NP_595946.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2297164..2300512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021854.2 → NP_595946.1  putative 6-phosphofructokinase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595946.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O42938, P78762
      Conserved Domains (2) summary
      TIGR02478
      Location:195 → 940
      6PF1K_euk; 6-phosphofructokinase, eukaryotic type
      cl00204
      Location:192 → 936
      PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. ...
    Nucleotide Protein
    Heading Accession and Version

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