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    LSM7 Sm-like protein LSM7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855575, updated on 19-Jun-2024

    Summary

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    Gene symbol
    LSM7
    Gene description
    Sm-like protein LSM7
    Primary source
    FungiDB:YNL147W
    Locus tag
    YNL147W
    See related
    SGD:S000005091; AllianceGenome:SGD:S000005091; VEuPathDB:YNL147W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to RNA binding activity. Involved in mRNA splicing, via spliceosome; maturation of SSU-rRNA; and nuclear-transcribed mRNA catabolic process. Located in cytoplasm and nucleolus. Part of Lsm1-7-Pat1 complex; sno(s)RNA-containing ribonucleoprotein complex; and spliceosomal snRNP complex. Orthologous to human LSM7 (LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See LSM7 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    2
    Sequence:
    Chromosome: XIV; NC_001146.8 (350940..351383)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Pga2p Neighboring gene Alf1p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exon sequences at the splice junctions affect splicing fidelity and alternative splicing. Crotti LB, et al. Proc Natl Acad Sci U S A, 2009 Nov 10. PMID 19855008, Free PMC Article
    2. The Lsm2-8 complex determines nuclear localization of the spliceosomal U6 snRNA. Spiller MP, et al. Nucleic Acids Res, 2007. PMID 17251193, Free PMC Article
    3. The Zymomonas mobilis regulator hfq contributes to tolerance against multiple lignocellulosic pretreatment inhibitors. Yang S, et al. BMC Microbiol, 2010 May 7. PMID 20459639, Free PMC Article
    4. LSm1-7 complexes bind to specific sites in viral RNA genomes and regulate their translation and replication. Galão RP, et al. RNA, 2010 Apr. PMID 20181739, Free PMC Article
    5. LSM1 over-expression in Saccharomyces cerevisiae depletes U6 snRNA levels. Luhtala N, et al. Nucleic Acids Res, 2009 Sep. PMID 19596813, Free PMC Article

    See all (114) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The middle domain of Pat1 is essential for the interaction of Pat1 with the Lsm1-7 complex in vivo.
      Title: Pat1 contributes to the RNA binding activity of the Lsm1-7-Pat1 complex.
    2. an Lsm2-Lsm7 protein complex resides in nucleoli, contributing to the biogenesis or function of specific snoRNAs
      Title: An Lsm2-Lsm7 complex in Saccharomyces cerevisiae associates with the small nucleolar RNA snR5.
    3. The Lsm1p-7p-Pat1p complex protects mRNAs by binding at/near the 3'end and distinguishes between oligoadenyLated and polyadenylated RNA.
      Title: The decapping activator Lsm1p-7p-Pat1p complex has the intrinsic ability to distinguish between oligoadenylated and polyadenylated RNAs.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of SSU-rRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Lsm1-7-Pat1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Lsm1-7-Pat1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U6 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U6 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sno(s)RNA-containing ribonucleoprotein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sm-like protein LSM7
    NP_014252.2
    • Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      350940..351383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182985.1 → NP_014252.2  TPA: Sm-like protein LSM7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014252.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W135, P53905
      UniProtKB/TrEMBL
      B3LP03, C7GXU8, C8ZG81, G2WLV9, N1NXT8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    3JCM_g.1
    4C8Q_G.1
    4M77_F.1
    4M77_M.1
    4M78_F.1
    4M78_M.1
    4M7A_F.1
    4M7A_M.1
    4M7D_F.1
    4M7D_M.1
    5ZWM_y.1
    5ZWO_y.1
    P53905.2

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