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    SPC25 kinetochore-associated Ndc80 complex subunit SPC25 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856738, updated on 17-May-2024

    Summary

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    Gene symbol
    SPC25
    Gene description
    kinetochore-associated Ndc80 complex subunit SPC25
    Primary source
    FungiDB:YER018C
    Locus tag
    YER018C
    See related
    SGD:S000000820; AllianceGenome:SGD:S000000820; VEuPathDB:YER018C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in centromere clustering and chromosome segregation. Located in kinetochore. Part of Ndc80 complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SPC25 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (191959..192624, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene microtubule-binding protein BIM1 Neighboring gene AAA family ATPase AFG3 Neighboring gene inositol phosphosphingolipid phospholipase Neighboring gene Arf family guanine nucleotide exchange factor SBH2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. Wei RR, et al. Structure, 2006 Jun. PMID 16765893
    2. Methylation of CENP-A/Cse4 on arginine 143 and lysine 131 regulates kinetochore stability in yeast. Tran Nguyen TM, et al. Genetics, 2023 Apr 6. PMID 36810679, Free PMC Article
    3. RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure. Schmitzberger F, et al. EMBO Rep, 2012 Mar 1. PMID 22322944, Free PMC Article
    4. Tight bending of the Ndc80 complex provides intrinsic regulation of its binding to microtubules. Scarborough EA, et al. Elife, 2019 May 2. PMID 31045495, Free PMC Article
    5. Conserved Tetramer Junction in the Kinetochore Ndc80 Complex. Valverde R, et al. Cell Rep, 2016 Nov 15. PMID 27851957, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centromere clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ndc80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Ndc80 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinetochore-associated Ndc80 complex subunit SPC25
    NP_010934.3
    • Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      191959..192624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178909.3 → NP_010934.3  TPA: kinetochore-associated Ndc80 complex subunit SPC25 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010934.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLR6, P40014
      UniProtKB/TrEMBL
      A0A8H8ULM9, A6ZQW6, G2WCQ0, N1P5R5
      Conserved Domains (1) summary
      PRK00286
      Location:8 → 131
      xseA; exodeoxyribonuclease VII large subunit; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40014.1

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