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    MAOB monoamine oxidase B [ Homo sapiens (human) ]

    Gene ID: 4129, updated on 11-Apr-2024

    Summary

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    Official Symbol
    MAOBprovided by HGNC
    Official Full Name
    monoamine oxidase Bprovided by HGNC
    Primary source
    HGNC:HGNC:6834
    See related
    Ensembl:ENSG00000069535 MIM:309860; AllianceGenome:HGNC:6834
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in liver (RPKM 72.6), ovary (RPKM 62.8) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MAOB in Genome Data Viewer
    Location:
    Xp11.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (43766610..43882450, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (43172827..43288647, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (43625857..43741696, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Nanog homeobox pseudogene 10 Neighboring gene MPRA-validated peak7375 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:43309398-43310202 Neighboring gene MPRA-validated peak7376 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chrX:43514055-43514449 Neighboring gene monoamine oxidase A Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:43808655-43809172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:43809173-43809689 Neighboring gene NDP antisense RNA 1 Neighboring gene norrin cystine knot growth factor NDP Neighboring gene RBM39 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD. Repovecki S, et al. Biomolecules, 2022 May 23. PMID 35625663, Free PMC Article
    2. Revisiting the Role of Astrocytic MAOB in Parkinson's Disease. Nam MH, et al. Int J Mol Sci, 2022 Apr 18. PMID 35457272, Free PMC Article
    3. Why Monoamine Oxidase B Preferably Metabolizes N-Methylhistamine over Histamine: Evidence from the Multiscale Simulation of the Rate-Limiting Step. Maršavelski A, et al. Int J Mol Sci, 2022 Feb 8. PMID 35163835, Free PMC Article
    4. Inhibition of monoamine oxidase B prevents reactive astrogliosis and scar formation in stab wound injury model. Chun H, et al. Glia, 2022 Feb. PMID 34713936
    5. Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males. Podobnik J, et al. Biomolecules, 2020 Nov 15. PMID 33203099, Free PMC Article

    See all (205) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAOB expression correlates with a favourable prognosis in prostate cancer, and its genetic variants are associated with the metastasis of the disease.
      Title: MAOB expression correlates with a favourable prognosis in prostate cancer, and its genetic variants are associated with the metastasis of the disease.
    2. Stromal-derived MAOB promotes prostate cancer growth and progression.
      Title: Stromal-derived MAOB promotes prostate cancer growth and progression.
    3. Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma.
      Title: Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma.
    4. Relationship of DRD5 and MAO-B VNTR polymorphisms with paranoid and antisocial personality disorders in polydrug users.
      Title: Relationship of DRD5 and MAO-B VNTR polymorphisms with paranoid and antisocial personality disorders in polydrug users.
    5. Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD.
      Title: Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD.
    6. Revisiting the Role of Astrocytic MAOB in Parkinson's Disease.
      Title: Revisiting the Role of Astrocytic MAOB in Parkinson's Disease.
    7. Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE epsilon4 Allele in Alzheimer's Disease.
      Title: Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer's Disease.
    8. Inhibition of monoamine oxidase B prevents reactive astrogliosis and scar formation in stab wound injury model.
      Title: Inhibition of monoamine oxidase B prevents reactive astrogliosis and scar formation in stab wound injury model.
    9. Why Monoamine Oxidase B Preferably Metabolizes N-Methylhistamine over Histamine: Evidence from the Multiscale Simulation of the Rate-Limiting Step.
      Title: Why Monoamine Oxidase B Preferably Metabolizes N-Methylhistamine over Histamine: Evidence from the Multiscale Simulation of the Rate-Limiting Step.
    10. Sex-dependent monoamine oxidase isoforms expression patterns during human brain ageing.
      Title: Sex-dependent monoamine oxidase isoforms expression patterns during human brain ageing.
    Submit: New GeneRIF Correction See all GeneRIFs (137)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC26382

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aliphatic amine oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables electron transfer activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoamine oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables primary amine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables primary amine oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables primary amine oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dopamine catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in hydrogen peroxide biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of serotonin secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phenylethylamine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of dopamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to aluminum ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to corticosterone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to selenium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in substantia nigra development HEP PubMed 
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial envelope TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    amine oxidase [flavin-containing] B
    Names
    MAO, brain
    MAO, platelet
    MAO-B
    adrenalin oxidase
    monoamine oxidase type B
    tyramine oxidase
    NP_000889.3
    XP_016885013.1
    XP_054183044.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008723.2 RefSeqGene

      Range
      5026..120866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000898.5 → NP_000889.3  amine oxidase [flavin-containing] B

      See identical proteins and their annotated locations for NP_000889.3

      Status: REVIEWED

      Source sequence(s)
      AL133791, BM726427, DC326844, M69177
      Consensus CDS
      CCDS14261.1
      UniProtKB/Swiss-Prot
      B2R6R3, B7Z5H3, D3DWC3, P27338, Q7Z6S2
      UniProtKB/TrEMBL
      Q8TBI1
      Related
      ENSP00000367309.4, ENST00000378069.5
      Conserved Domains (1) summary
      pfam01593
      Location:14 → 451
      Amino_oxidase; Flavin containing amine oxidoreductase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      43766610..43882450 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029524.3 → XP_016885013.1  amine oxidase [flavin-containing] B isoform X1

      UniProtKB/TrEMBL
      B7Z242, Q8TBI1
      Conserved Domains (2) summary
      pfam01593
      Location:1 → 435
      Amino_oxidase; Flavin containing amine oxidoreductase
      pfam13450
      Location:1 → 59
      NAD_binding_8; NAD(P)-binding Rossmann-like domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      43172827..43288647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327069.1 → XP_054183044.1  amine oxidase [flavin-containing] B isoform X1

      UniProtKB/TrEMBL
      B7Z242
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27338.3 GenPept UniProtKB/Swiss-Prot:P27338

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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