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    SORBS2 sorbin and SH3 domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 8470, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SORBS2provided by HGNC
    Official Full Name
    sorbin and SH3 domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:24098
    See related
    Ensembl:ENSG00000154556 MIM:616349; AllianceGenome:HGNC:24098
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARGBP2; PRO0618
    Summary
    Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in heart (RPKM 46.6), adrenal (RPKM 26.3) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    4q35.1
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (185585523..185956372, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (188926307..189297353, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (186506677..186877526, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15856 Neighboring gene uncharacterized LOC105377590 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:186401399-186401900 Neighboring gene coiled-coil domain containing 110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:186423455-186423954 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:186434842-186436041 Neighboring gene PDZ and LIM domain 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:186480278-186481124 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:186481125-186481969 Neighboring gene VISTA enhancer hs2502 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:186508176-186509375 Neighboring gene SORBS2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:186559524-186560163 Neighboring gene Sharpr-MPRA regulatory region 2405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:186633271-186633806 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:186650535-186650732 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:186658253-186658822 Neighboring gene Sharpr-MPRA regulatory region 123 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:186717334-186717850 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:186717851-186718366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:186742039-186742866 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:186760070-186761269 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:186784850-186784952 Neighboring gene uncharacterized LOC101928929 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124900828 Neighboring gene uncharacterized LOC124900830 Neighboring gene uncharacterized LOC124900829

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Musk ketone induces apoptosis of gastric cancer cells via downregulation of sorbin and SH3 domain containing 2. An J, et al. Mol Med Rep, 2021 Jun. PMID 33880576, Free PMC Article
    2. Elevated myocardial SORBS2 and the underlying implications in left ventricular noncompaction cardiomyopathy. Li C, et al. EBioMedicine, 2020 Mar. PMID 32143182, Free PMC Article
    3. The RNA binding protein SORBS2 suppresses metastatic colonization of ovarian cancer by stabilizing tumor-suppressive immunomodulatory transcripts. Zhao L, et al. Genome Biol, 2018 Mar 16. PMID 29548303, Free PMC Article
    4. Sorbin and SH3 domain-containing protein 2 (SORBS2) is a component of the acto-myosin ring at the apical junctional complex in epithelial cells. Fredriksson-Lidman K, et al. PLoS One, 2017. PMID 28961272, Free PMC Article
    5. SORBS2 transcription is activated by telomere position effect-over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy. Robin JD, et al. Genome Res, 2015 Dec. PMID 26359233, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients.
      Title: SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients.
    2. Musk ketone induces apoptosis of gastric cancer cells via downregulation of sorbin and SH3 domain containing 2.
      Title: Musk ketone induces apoptosis of gastric cancer cells via downregulation of sorbin and SH3 domain containing 2.
    3. LncRNA H19 Inhibits the Progression of Sepsis-Induced Myocardial Injury via Regulation of the miR-93-5p/SORBS2 Axis.
      Title: LncRNA H19 Inhibits the Progression of Sepsis-Induced Myocardial Injury via Regulation of the miR-93-5p/SORBS2 Axis.
    4. RNA-binding protein SORBS2 suppresses clear cell renal cell carcinoma metastasis by enhancing MTUS1 mRNA stability.
      Title: RNA-binding protein SORBS2 suppresses clear cell renal cell carcinoma metastasis by enhancing MTUS1 mRNA stability.
    5. Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy.
      Title: Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy.
    6. Elevated myocardial SORBS2 and the underlying implications in left ventricular noncompaction cardiomyopathy.
      Title: Elevated myocardial SORBS2 and the underlying implications in left ventricular noncompaction cardiomyopathy.
    7. The RNA-binding protein SORBS2 suppresses hepatocellular carcinoma tumourigenesis and metastasis by stabilizing RORA mRNA.
      Title: The RNA-binding protein SORBS2 suppresses hepatocellular carcinoma tumourigenesis and metastasis by stabilizing RORA mRNA.
    8. By enhancing the stability of gene transcripts, SORBS2 suppresses ovarian cancer invasiveness and affects monocyte to myeloid-derived suppressor cell and M2-like macrophage polarization, eliciting a tumor-suppressive immune microenvironment.
      Title: The RNA binding protein SORBS2 suppresses metastatic colonization of ovarian cancer by stabilizing tumor-suppressive immunomodulatory transcripts.
    9. results thus contribute to the knowledge of the regulatory mechanism of HSF1 in down-regulating ArgBP2, providing new insight into the HSF1&MORC2-PRC2-ArgBP2 signaling pathway and a better understanding of their functions in gastric cancer cells.
      Title: HSF1, in association with MORC2, downregulates ArgBP2 via the PRC2 family in gastric cancer cells.
    10. In spite of our finding that SORBS2 is clearly a component of the apical junction complex, it does not appear to be required for either normal tight- or adherens junction assembly, structure or function or for growth factor-mediated changes in tight junction dynamics
      Title: Sorbin and SH3 domain-containing protein 2 (SORBS2) is a component of the acto-myosin ring at the apical junctional complex in epithelial cells.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr upregulates SORBS2 in HeLa cells within 12 hours of exposure PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ93447, KIAA0777

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables cytoskeletal anchor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables structural constituent of muscle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell growth involved in cardiac muscle cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Z disc NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in actin cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sorbin and SH3 domain-containing protein 2
    Names
    Arg binding protein 2
    Arg/Abl-interacting protein 2
    arg-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029709.1 RefSeqGene

      Range
      149523..376194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001145670.2 → NP_001139142.1  sorbin and SH3 domain-containing protein 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) originates from an alternate promoter and has a different 5'UTR and first coding exon compared to variant 1. The resulting protein isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC093797, AC104805, AC108472
      Consensus CDS
      CCDS47173.1
      UniProtKB/TrEMBL
      H7BXR3
      Related
      ENSP00000397262.2, ENST00000449407.6
      Conserved Domains (3) summary
      cd11923
      Location:485 → 541
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      pfam02208
      Location:156 → 197
      Sorb; Sorbin homologous domain
      cl17036
      Location:584 → 644
      SH3; Src Homology 3 domain superfamily

    2. NM_001145671.3 → NP_001139143.1  sorbin and SH3 domain-containing protein 2 isoform 4

      See identical proteins and their annotated locations for NP_001139143.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) originates from an alternate promoter and has a different 5'UTR and first coding exon and includes alternate in-frame exons compared to variant 1. The resulting protein isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC093797, AC104805, AC108472
      Consensus CDS
      CCDS47174.1
      UniProtKB/TrEMBL
      H7BXR3
      Related
      ENSP00000322182.9, ENST00000319471.13
      Conserved Domains (3) summary
      smart00459
      Location:153 → 203
      Sorb; Sorbin homologous domain
      cd11923
      Location:572 → 628
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:671 → 731
      SH3; Src Homology 3 domain superfamily

    3. NM_001145672.2 → NP_001139144.1  sorbin and SH3 domain-containing protein 2 isoform 5

      See identical proteins and their annotated locations for NP_001139144.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) originates from an alternate promoter and has a different 5'UTR and first coding exon and includes alternate in-frame exons compared to variant 1. The resulting protein isoform (5) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC093797, AC104805, AC108472
      Consensus CDS
      CCDS54825.1
      UniProtKB/TrEMBL
      H7BXR3
      Related
      ENSP00000401818.2, ENST00000451974.6
      Conserved Domains (4) summary
      cd11923
      Location:502 → 558
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      PHA03132
      Location:219 → 411
      PHA03132; thymidine kinase; Provisional
      pfam02208
      Location:139 → 183
      Sorb; Sorbin homologous domain
      cl17036
      Location:601 → 661
      SH3; Src Homology 3 domain superfamily

    4. NM_001145673.3 → NP_001139145.1  sorbin and SH3 domain-containing protein 2 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) originates from an alternate promoter and has a different 5'UTR and first coding exon and includes alternate in-frame exons compared to variant 1. The resulting protein isoform (6) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC093797, AC104805, AC108472
      Consensus CDS
      CCDS47175.1
      UniProtKB/TrEMBL
      A0A9L9PXP6
      Related
      ENSP00000396008.2, ENST00000437304.6
      Conserved Domains (3) summary
      cd11923
      Location:665 → 721
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      pfam02208
      Location:249 → 293
      Sorb; Sorbin homologous domain
      cl17036
      Location:764 → 824
      SH3; Src Homology 3 domain superfamily

    5. NM_001145674.3 → NP_001139146.1  sorbin and SH3 domain-containing protein 2 isoform 7

      See identical proteins and their annotated locations for NP_001139146.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) originates from an alternate promoter and has a different 5'UTR and first coding exon compared to variant 1. The resulting protein isoform (7) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC093797
      Consensus CDS
      CCDS47176.1
      UniProtKB/Swiss-Prot
      O94875
      Related
      ENSP00000511887.1, ENST00000487836.6
      Conserved Domains (4) summary
      cd11917
      Location:944 → 1004
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:845 → 901
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl02617
      Location:8 → 29
      Sorb; Sorbin homologous domain
      cl17036
      Location:770 → 824
      SH3; Src Homology 3 domain superfamily

    6. NM_001145675.3 → NP_001139147.1  sorbin and SH3 domain-containing protein 2 isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) originates from an alternate promoter and has a different 5' UTR and first coding exon compared to variant 1. The resulting protein isoform (8) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC093797
      Consensus CDS
      CCDS93677.1
      UniProtKB/TrEMBL
      A0A8Q3WKF2, B7Z997
      Related
      ENSP00000511889.1, ENST00000490562.6
      Conserved Domains (3) summary
      cd11923
      Location:333 → 389
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl02617
      Location:8 → 33
      Sorb; Sorbin homologous domain
      cl17036
      Location:432 → 492
      SH3; Src Homology 3 domain superfamily

    7. NM_001270771.3 → NP_001257700.1  sorbin and SH3 domain-containing protein 2 isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) originates from an alternate promoter, has a different 5' UTR, and several in-frame differences in the coding region compared to variant 1, which results in a longer isoform (7) compared to isoform 1.
      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      Consensus CDS
      CCDS59482.1
      UniProtKB/Swiss-Prot
      O94875
      Related
      ENSP00000347852.5, ENST00000355634.9
      Conserved Domains (4) summary
      cd11917
      Location:1140 → 1200
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:966 → 1020
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1041 → 1097
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      pfam02208
      Location:170 → 214
      Sorb; Sorbin homologous domain

    8. NM_001394245.1 → NP_001381174.1  sorbin and SH3 domain-containing protein 2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:153 → 203
      Sorb; Sorbin homologous domain
      cd11917
      Location:1226 → 1286
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:1052 → 1106
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1127 → 1183
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    9. NM_001394246.1 → NP_001381175.1  sorbin and SH3 domain-containing protein 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:153 → 203
      Sorb; Sorbin homologous domain
      cd11917
      Location:1207 → 1267
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:1033 → 1087
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1108 → 1164
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    10. NM_001394247.1 → NP_001381176.1  sorbin and SH3 domain-containing protein 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:153 → 203
      Sorb; Sorbin homologous domain
      cd11917
      Location:1207 → 1267
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:1033 → 1087
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1108 → 1164
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    11. NM_001394248.1 → NP_001381177.1  sorbin and SH3 domain-containing protein 2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:130 → 180
      Sorb; Sorbin homologous domain
      cd11917
      Location:1184 → 1244
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:1010 → 1064
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1085 → 1141
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    12. NM_001394249.1 → NP_001381178.1  sorbin and SH3 domain-containing protein 2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:130 → 180
      Sorb; Sorbin homologous domain
      cd11917
      Location:1184 → 1244
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:1010 → 1064
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1085 → 1141
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    13. NM_001394250.1 → NP_001381179.1  sorbin and SH3 domain-containing protein 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:153 → 203
      Sorb; Sorbin homologous domain
      cd11917
      Location:1179 → 1239
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:1005 → 1059
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1080 → 1136
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    14. NM_001394251.1 → NP_001381180.1  sorbin and SH3 domain-containing protein 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Consensus CDS
      CCDS59482.1
      Conserved Domains (4) summary
      cd11917
      Location:1140 → 1200
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:966 → 1020
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1041 → 1097
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      pfam02208
      Location:170 → 214
      Sorb; Sorbin homologous domain

    15. NM_001394252.1 → NP_001381181.1  sorbin and SH3 domain-containing protein 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Consensus CDS
      CCDS59482.1
      Conserved Domains (4) summary
      cd11917
      Location:1140 → 1200
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:966 → 1020
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1041 → 1097
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      pfam02208
      Location:170 → 214
      Sorb; Sorbin homologous domain

    16. NM_001394253.1 → NP_001381182.1  sorbin and SH3 domain-containing protein 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Consensus CDS
      CCDS59482.1
      Conserved Domains (4) summary
      cd11917
      Location:1140 → 1200
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:966 → 1020
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1041 → 1097
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      pfam02208
      Location:170 → 214
      Sorb; Sorbin homologous domain

    17. NM_001394254.1 → NP_001381183.1  sorbin and SH3 domain-containing protein 2 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Consensus CDS
      CCDS93678.1
      UniProtKB/TrEMBL
      A0A8Q3WKH1
      Related
      ENSP00000511891.1, ENST00000695410.1
      Conserved Domains (4) summary
      smart00459
      Location:67 → 117
      Sorb; Sorbin homologous domain
      cd11917
      Location:1140 → 1200
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:966 → 1020
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1041 → 1097
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    18. NM_001394255.1 → NP_001381184.1  sorbin and SH3 domain-containing protein 2 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:153 → 203
      Sorb; Sorbin homologous domain
      cd11917
      Location:1126 → 1186
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:952 → 1006
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1027 → 1083
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    19. NM_001394256.1 → NP_001381185.1  sorbin and SH3 domain-containing protein 2 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:153 → 203
      Sorb; Sorbin homologous domain
      cd11917
      Location:1126 → 1186
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:952 → 1006
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1027 → 1083
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    20. NM_001394257.1 → NP_001381186.1  sorbin and SH3 domain-containing protein 2 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:153 → 203
      Sorb; Sorbin homologous domain
      cd11917
      Location:1126 → 1186
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:952 → 1006
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1027 → 1083
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    21. NM_001394258.1 → NP_001381187.1  sorbin and SH3 domain-containing protein 2 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:67 → 117
      Sorb; Sorbin homologous domain
      cd11917
      Location:1121 → 1181
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:947 → 1001
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1022 → 1078
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    22. NM_001394259.1 → NP_001381188.1  sorbin and SH3 domain-containing protein 2 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:153 → 198
      Sorb; Sorbin homologous domain
      cd11917
      Location:1111 → 1171
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:937 → 991
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1012 → 1068
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    23. NM_001394260.1 → NP_001381189.1  sorbin and SH3 domain-containing protein 2 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:153 → 198
      Sorb; Sorbin homologous domain
      cd11917
      Location:1111 → 1171
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:937 → 991
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1012 → 1068
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    24. NM_001394261.1 → NP_001381190.1  sorbin and SH3 domain-containing protein 2 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:136 → 186
      Sorb; Sorbin homologous domain
      cd11917
      Location:1109 → 1169
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:935 → 989
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1010 → 1066
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    25. NM_001394262.1 → NP_001381191.1  sorbin and SH3 domain-containing protein 2 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:130 → 180
      Sorb; Sorbin homologous domain
      cd11917
      Location:1103 → 1163
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:929 → 983
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1004 → 1060
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    26. NM_001394263.1 → NP_001381192.1  sorbin and SH3 domain-containing protein 2 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:130 → 180
      Sorb; Sorbin homologous domain
      cd11917
      Location:1103 → 1163
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:929 → 983
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1004 → 1060
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    27. NM_001394264.1 → NP_001381193.1  sorbin and SH3 domain-containing protein 2 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:67 → 112
      Sorb; Sorbin homologous domain
      cd11917
      Location:1078 → 1138
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:904 → 958
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:979 → 1035
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    28. NM_001394265.1 → NP_001381194.1  sorbin and SH3 domain-containing protein 2 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:113 → 158
      Sorb; Sorbin homologous domain
      cd11917
      Location:1071 → 1131
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:897 → 951
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:972 → 1028
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    29. NM_001394266.1 → NP_001381195.1  sorbin and SH3 domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      Consensus CDS
      CCDS3845.1
      UniProtKB/Swiss-Prot
      A6NEK9, B3KPQ7, B7Z1G5, B7Z3X6, C9JKV9, D3DP62, D3DP63, E9PAS5, E9PAW4, G3XAI0, H7BXR4, J3KNZ5, O60592, O60593, O94875, Q96EX0
      Conserved Domains (4) summary
      smart00459
      Location:67 → 117
      Sorb; Sorbin homologous domain
      cd11917
      Location:1040 → 1100
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:866 → 920
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:941 → 997
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    30. NM_001394267.1 → NP_001381196.1  sorbin and SH3 domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      Consensus CDS
      CCDS3845.1
      UniProtKB/Swiss-Prot
      A6NEK9, B3KPQ7, B7Z1G5, B7Z3X6, C9JKV9, D3DP62, D3DP63, E9PAS5, E9PAW4, G3XAI0, H7BXR4, J3KNZ5, O60592, O60593, O94875, Q96EX0
      Conserved Domains (4) summary
      smart00459
      Location:67 → 117
      Sorb; Sorbin homologous domain
      cd11917
      Location:1040 → 1100
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:866 → 920
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:941 → 997
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    31. NM_001394268.1 → NP_001381197.1  sorbin and SH3 domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      Consensus CDS
      CCDS3845.1
      UniProtKB/Swiss-Prot
      A6NEK9, B3KPQ7, B7Z1G5, B7Z3X6, C9JKV9, D3DP62, D3DP63, E9PAS5, E9PAW4, G3XAI0, H7BXR4, J3KNZ5, O60592, O60593, O94875, Q96EX0
      Conserved Domains (4) summary
      smart00459
      Location:67 → 117
      Sorb; Sorbin homologous domain
      cd11917
      Location:1040 → 1100
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:866 → 920
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:941 → 997
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    32. NM_001394270.1 → NP_001381199.1  sorbin and SH3 domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Consensus CDS
      CCDS3845.1
      UniProtKB/Swiss-Prot
      A6NEK9, B3KPQ7, B7Z1G5, B7Z3X6, C9JKV9, D3DP62, D3DP63, E9PAS5, E9PAW4, G3XAI0, H7BXR4, J3KNZ5, O60592, O60593, O94875, Q96EX0
      Conserved Domains (4) summary
      smart00459
      Location:67 → 117
      Sorb; Sorbin homologous domain
      cd11917
      Location:1040 → 1100
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:866 → 920
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:941 → 997
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    33. NM_001394271.1 → NP_001381200.1  sorbin and SH3 domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Consensus CDS
      CCDS3845.1
      UniProtKB/Swiss-Prot
      A6NEK9, B3KPQ7, B7Z1G5, B7Z3X6, C9JKV9, D3DP62, D3DP63, E9PAS5, E9PAW4, G3XAI0, H7BXR4, J3KNZ5, O60592, O60593, O94875, Q96EX0
      Conserved Domains (4) summary
      smart00459
      Location:67 → 117
      Sorb; Sorbin homologous domain
      cd11917
      Location:1040 → 1100
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:866 → 920
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:941 → 997
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    34. NM_001394272.1 → NP_001381201.1  sorbin and SH3 domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Consensus CDS
      CCDS3845.1
      UniProtKB/Swiss-Prot
      A6NEK9, B3KPQ7, B7Z1G5, B7Z3X6, C9JKV9, D3DP62, D3DP63, E9PAS5, E9PAW4, G3XAI0, H7BXR4, J3KNZ5, O60592, O60593, O94875, Q96EX0
      Conserved Domains (4) summary
      smart00459
      Location:67 → 117
      Sorb; Sorbin homologous domain
      cd11917
      Location:1040 → 1100
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:866 → 920
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:941 → 997
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    35. NM_001394273.1 → NP_001381202.1  sorbin and SH3 domain-containing protein 2 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC093797
      Conserved Domains (4) summary
      cd11917
      Location:1031 → 1091
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:857 → 911
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:932 → 988
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl02617
      Location:4 → 36
      Sorb; Sorbin homologous domain

    36. NM_001394274.1 → NP_001381203.1  sorbin and SH3 domain-containing protein 2 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:67 → 112
      Sorb; Sorbin homologous domain
      cd11917
      Location:1025 → 1085
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:851 → 905
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:926 → 982
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    37. NM_001394275.1 → NP_001381204.1  sorbin and SH3 domain-containing protein 2 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:67 → 112
      Sorb; Sorbin homologous domain
      cd11917
      Location:1025 → 1085
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:851 → 905
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:926 → 982
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    38. NM_001394276.1 → NP_001381205.1  sorbin and SH3 domain-containing protein 2 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:485 → 535
      Sorb; Sorbin homologous domain
      cd11917
      Location:1003 → 1063
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:829 → 883
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:904 → 960
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    39. NM_001394277.1 → NP_001381206.1  sorbin and SH3 domain-containing protein 2 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC093797
      Conserved Domains (4) summary
      cd11917
      Location:959 → 1019
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:785 → 839
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:860 → 916
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl02617
      Location:4 → 36
      Sorb; Sorbin homologous domain

    40. NM_001395207.1 → NP_001382136.1  sorbin and SH3 domain-containing protein 2 isoform 26

      Status: REVIEWED

      Description
      Transcript Variant: This variant (42) represents the longest transcript and encodes the longest isoform (26).
      Source sequence(s)
      AC093797, AC104805, AC108472
      Consensus CDS
      CCDS93679.1
      UniProtKB/TrEMBL
      A0A8Q3WKK4
      Related
      ENSP00000511888.1, ENST00000695409.1
      Conserved Domains (4) summary
      smart00459
      Location:167 → 217
      Sorb; Sorbin homologous domain
      cd11917
      Location:1240 → 1300
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:1066 → 1120
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:1141 → 1197
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    41. NM_003603.7 → NP_003594.3  sorbin and SH3 domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_003594.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs at the 5' end, and contains a small in-frame insertion and a large in-frame deletion compared to transcript variant 2. It encodes a shorter isoform (1) with a different amino-terminal, but the same carboxy-terminal sequence containing three SH3 domains, as isoform 2.
      Source sequence(s)
      AC093797, AC104805, AC108472
      Consensus CDS
      CCDS43289.2
      UniProtKB/TrEMBL
      H7BXR3
      Related
      ENSP00000377162.3, ENST00000393528.7
      Conserved Domains (3) summary
      smart00459
      Location:113 → 163
      Sorb; Sorbin homologous domain
      cd11923
      Location:507 → 563
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:606 → 666
      SH3; Src Homology 3 domain superfamily

    42. NM_021069.6 → NP_066547.1  sorbin and SH3 domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_066547.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs at the 5' end, and contains a large in-frame insertion and a small in-frame deletion compared to transcript variant 1. It encodes a longer isoform (2) with a different amino-terminal, but the same carboxy-terminal sequence containing three SH3 domains, as isoform 1.
      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      Consensus CDS
      CCDS3845.1
      UniProtKB/Swiss-Prot
      A6NEK9, B3KPQ7, B7Z1G5, B7Z3X6, C9JKV9, D3DP62, D3DP63, E9PAS5, E9PAW4, G3XAI0, H7BXR4, J3KNZ5, O60592, O60593, O94875, Q96EX0
      Related
      ENSP00000284776.7, ENST00000284776.11
      Conserved Domains (4) summary
      smart00459
      Location:67 → 117
      Sorb; Sorbin homologous domain
      cd11917
      Location:1040 → 1100
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:866 → 920
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:941 → 997
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      185585523..185956372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      188926307..189297353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O94875.3 GenPept UniProtKB/Swiss-Prot:O94875

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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