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    Lgals3 lectin, galactose binding, soluble 3 [ Mus musculus (house mouse) ]

    Gene ID: 16854, updated on 5-Jul-2021

    Summary

    Official Symbol
    Lgals3provided by MGI
    Official Full Name
    lectin, galactose binding, soluble 3provided by MGI
    Primary source
    MGI:MGI:96778
    See related
    Ensembl:ENSMUSG00000050335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ga; GBP; L-3; L-34; Mac-; gal3; Mac-2; galect
    Expression
    Biased expression in colon adult (RPKM 931.1), duodenum adult (RPKM 311.5) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Lgals3 in Genome Data Viewer
    Location:
    14; 14 C1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (47611317..47623624)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (47373860..47386167)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (47993535..48005842)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118568146 Neighboring gene predicted gene, 52166 Neighboring gene DLG associated protein 5 Neighboring gene ribosomal protein S15 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Fc-gamma receptor I complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables IgE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables IgE binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables advanced glycation end-product receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chemoattractant activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables disaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables laminin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables laminin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables monosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oligosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in eosinophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in eosinophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within extracellular matrix organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in killing of cells of other organism ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macrophage chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in maintenance of protein location IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in monocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mononuclear cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell proliferation in bone marrow ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of immunological synapse formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion import IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mononuclear cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of serotonin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of T cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glial cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in immunological synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    galectin-3
    Names
    35 kDa lectin
    CBP 35
    L-34 galactoside-binding lectin
    carbohydrate-binding protein 35
    gal-3
    galactose-specific lectin 3
    igE-binding protein
    laminin-binding protein
    lectin L-29
    mac-2 antigen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145953.1NP_001139425.1  galectin-3

      See identical proteins and their annotated locations for NP_001139425.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC123665, AK149783, BY440035
      Consensus CDS
      CCDS26986.1
      UniProtKB/TrEMBL
      Q8C253
      Related
      ENSMUSP00000114350.2, ENSMUST00000150290.9
      Conserved Domains (2) summary
      smart00908
      Location:137258
      Gal-bind_lectin; Galactoside-binding lectin
      pfam02084
      Location:18110
      Bindin; Bindin
    2. NM_010705.3NP_034835.1  galectin-3

      See identical proteins and their annotated locations for NP_034835.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK149783, BB853044, BY440035
      Consensus CDS
      CCDS26986.1
      UniProtKB/TrEMBL
      Q8C253
      Related
      ENSMUSP00000118169.2, ENSMUST00000142734.8
      Conserved Domains (2) summary
      smart00908
      Location:137258
      Gal-bind_lectin; Galactoside-binding lectin
      pfam02084
      Location:18110
      Bindin; Bindin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      47611317..47623624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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