Ugt2b36 UDP glucuronosyltransferase 2 family, polypeptide B36 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ugt2b36provided by MGI
Official Full Name: UDP glucuronosyltransferase 2 family, polypeptide B36provided by MGI
Primary source: MGI:MGI:3576103
See related: Ensembl:ENSMUSG00000070704 AllianceGenome:MGI:3576103
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable glucuronosyltransferase activity. Predicted to be involved in aromatic compound catabolic process. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human UGT2B15 (UDP glucuronosyltransferase family 2 member B15) and UGT2B17 (UDP glucuronosyltransferase family 2 member B17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 71.8), liver E18 (RPKM 5.2) and 2 other tissues See more
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Genomic context

Location:: 5 E1; 5 43.56 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (87213786..87240414, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (87065927..87092555, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Shp regulated morphine withdrawal syndrome via modulation of Ugt2b expression.
Title: The nuclear receptor Shp regulates morphine withdrawal syndrome via modulation of Ugt2b expression in mice.
As Ugt2b36 is highly expressed in the liver, it is most likely that Ugt2b36 is a major morphine Ugt in mouse liver.
Title: Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation.

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glucuronosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucuronosyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in androgen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in aromatic compound catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular glucuronidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular glucuronidation	ISO Inferred from Sequence Orthology more info
involved_in estrogen metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in estrogen metabolic process	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: UDP glucuronosyltransferase 2 family, polypeptide B36

NP_001025038.1

EC 2.4.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029867.1 → NP_001025038.1 UDP glucuronosyltransferase 2 family, polypeptide B36 precursor

See identical proteins and their annotated locations for NP_001025038.1

Status: PROVISIONAL

Source sequence(s)

AC100269, AC119816

Consensus CDS

CCDS19384.1

UniProtKB/TrEMBL

B9EIY3, Q3UEP4

Related

ENSMUSP00000092233.5, ENSMUST00000094649.11

Conserved Domains (2) summary

PHA03392
Location:8 → 506

egt; ecdysteroid UDP-glucosyltransferase; Provisional

pfam00201
Location:24 → 527

UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase