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    Ccna1 cyclin A1 [ Mus musculus (house mouse) ]

    Gene ID: 12427, updated on 12-May-2024

    Summary

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    Official Symbol
    Ccna1provided by MGI
    Official Full Name
    cyclin A1provided by MGI
    Primary source
    MGI:MGI:108042
    See related
    Ensembl:ENSMUSG00000027793 AllianceGenome:MGI:108042
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to act upstream of or within several processes, including cell division; meiotic cell cycle; and spermatogenesis. Part of cyclin A1-CDK2 complex. Is expressed in several structures, including blastocyst; liver; testis; and tooth. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human CCNA1 (cyclin A1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 38.8) and limb E14.5 (RPKM 0.7) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 C; 3 26.52 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (54952890..54965055, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (55045469..55057634, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene serine rich and transmembrane domain containing 1 Neighboring gene predicted gene, 31358 Neighboring gene STARR-seq mESC enhancer starr_07690 Neighboring gene RIKEN cDNA 4931419H13 gene Neighboring gene STARR-seq mESC enhancer starr_07692 Neighboring gene STARR-seq mESC enhancer starr_07693 Neighboring gene STARR-seq mESC enhancer starr_07694 Neighboring gene spartin Neighboring gene coiled-coil domain containing 169

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hyperactivation of cyclin A-CDK induces centrosome overduplication and chromosome tetraploidization in mouse cells. Niwa T, et al. Biochem Biophys Res Commun, 2021 Apr 16. PMID 33667714
    2. Overexpression of cyclin A1 promotes meiotic resumption but induces premature chromosome separation in mouse oocyte. Li J, et al. J Cell Physiol, 2020 Oct. PMID 32030765
    3. Meiotic failure in cyclin A1-deficient mouse spermatocytes triggers apoptosis through intrinsic and extrinsic signaling pathways and 14-3-3 proteins. Panigrahi SK, et al. PLoS One, 2017. PMID 28301569, Free PMC Article
    4. A Limited Role for the Cell Cycle Regulator Cyclin A1 in Murine Leukemogenesis. Bäumer N, et al. PLoS One, 2015. PMID 26080083, Free PMC Article
    5. Cyclin A1 is expressed in mouse ovary. Wei H, et al. Int J Med Sci, 2014. PMID 24904232, Free PMC Article

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing transforming growth factor-beta (TGF-beta) pathway in osteoblasts.
      Title: Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing transforming growth factor-beta (TGF-beta) pathway in osteoblasts.
    2. Galectin-12 modulates sebocyte proliferation and cell cycle progression by regulating cyclin A1 and CDK2.
      Title: Galectin-12 modulates sebocyte proliferation and cell cycle progression by regulating cyclin A1 and CDK2.
    3. Hyperactivation of cyclin A-CDK induces centrosome overduplication and chromosome tetraploidization in mouse cells.
      Title: Hyperactivation of cyclin A-CDK induces centrosome overduplication and chromosome tetraploidization in mouse cells.
    4. Overexpression of cyclin A1 promotes meiotic resumption but induces premature chromosome separation in mouse oocyte.
      Title: Overexpression of cyclin A1 promotes meiotic resumption but induces premature chromosome separation in mouse oocyte.
    5. Cyclin A1 in Oocytes Prevents Chromosome Segregation And Anaphase Entry.
      Title: Cyclin A1 in Oocytes Prevents Chromosome Segregation And Anaphase Entry.
    6. wild type control, 14-3-3 is detected in both cytosolic and nuclear fractions whereas it is restricted to the cytoplasm in mutant testes. This differential distribution of 14-3-3 may contribute to the induction of apoptosis in Ccna1-deficient spermatocytes
      Title: Meiotic failure in cyclin A1-deficient mouse spermatocytes triggers apoptosis through intrinsic and extrinsic signaling pathways and 14-3-3 proteins.
    7. cyclin A1 in association with vascular endothelial growth factor receptor 1 (VEGFR1), is required for HSPC and their niches to maintain their function and proper interaction
      Title: Cyclin A1 regulates the interactions between mouse haematopoietic stem and progenitor cells and their niches.
    8. Neither overexpression nor loss of cyclin A1 significantly altered leukemogenesis in PML-RARalpha-knockin mice.
      Title: A Limited Role for the Cell Cycle Regulator Cyclin A1 in Murine Leukemogenesis.
    9. With the recent data on the functions of cyclins in somatic and stem cells, we also discussed the possibilities of further studies of cyclin A1 in mouse oocytes and perhaps in the oogonial stem cells
      Title: Cyclin A1 is expressed in mouse ovary.
    10. Sp1 and possibly GATA1 bind concomitantly to the Ccna1 promoter and suppress its activity in vivo.
      Title: Sp1 transcription factor and GATA1 cis-acting elements modulate testis-specific expression of mouse cyclin A1.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC159139

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin A1-CDK2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cyclin A2-CDK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305221.2 → NP_001292150.1  cyclin-A1 isoform 1

      See identical proteins and their annotated locations for NP_001292150.1

      Status: VALIDATED

      Source sequence(s)
      AC127334
      Consensus CDS
      CCDS17356.1
      UniProtKB/Swiss-Prot
      Q61456, Q8C5U1
      Related
      ENSMUSP00000143447.2, ENSMUST00000198320.5
      Conserved Domains (3) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    2. NM_001428404.1 → NP_001415333.1  cyclin-A1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC127334
      UniProtKB/Swiss-Prot
      Q61456, Q8C5U1

    3. NM_001428405.1 → NP_001415334.1  cyclin-A1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC127334

    4. NM_001428406.1 → NP_001415335.1  cyclin-A1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127334

    5. NM_001428407.1 → NP_001415336.1  cyclin-A1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC127334

    6. NM_007628.4 → NP_031654.2  cyclin-A1 isoform 1

      See identical proteins and their annotated locations for NP_031654.2

      Status: VALIDATED

      Source sequence(s)
      AC127334
      Consensus CDS
      CCDS17356.1
      UniProtKB/Swiss-Prot
      Q61456, Q8C5U1
      Related
      ENSMUSP00000029368.3, ENSMUST00000029368.7
      Conserved Domains (3) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    RNA

    1. NR_190341.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC127334

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      54952890..54965055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252400.1 → XP_030108260.1  cyclin-A1 isoform X2

      Conserved Domains (3) summary
      pfam00134
      Location:170 → 296
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:298 → 360
      Cyclin_C; Cyclin, C-terminal domain
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N

    2. XM_030252402.1 → XP_030108262.1  cyclin-A1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JEB5
      Related
      ENSMUSP00000142706.2, ENSMUST00000198102.5
      Conserved Domains (2) summary
      pfam00134
      Location:30 → 132
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:134 → 196
      Cyclin_C; Cyclin, C-terminal domain

    3. XM_006500951.4 → XP_006501014.1  cyclin-A1 isoform X1

      See identical proteins and their annotated locations for XP_006501014.1

      UniProtKB/Swiss-Prot
      Q61456, Q8C5U1
      Conserved Domains (3) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    4. XM_006500952.4 → XP_006501015.1  cyclin-A1 isoform X1

      See identical proteins and their annotated locations for XP_006501015.1

      UniProtKB/Swiss-Prot
      Q61456, Q8C5U1
      Related
      ENSMUSP00000142692.2, ENSMUST00000197238.5
      Conserved Domains (3) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    5. XM_036162875.1 → XP_036018768.1  cyclin-A1 isoform X4

      Conserved Domains (2) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cl40454
      Location:132 → 270
      CYCLIN_SF; Cyclin box fold superfamily

    6. XM_036162876.1 → XP_036018769.1  cyclin-A1 isoform X4

      Conserved Domains (2) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cl40454
      Location:132 → 270
      CYCLIN_SF; Cyclin box fold superfamily

    7. XM_006500954.5 → XP_006501017.1  cyclin-A1 isoform X3

      Conserved Domains (3) summary
      COG5024
      Location:134 → 386
      COG5024; Cyclin [Cell division and chromosome partitioning]
      pfam00134
      Location:170 → 272
      Cyclin_N; Cyclin, N-terminal domain
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N

    8. XM_030252399.2 → XP_030108259.1  cyclin-A1 isoform X2

      Conserved Domains (3) summary
      pfam00134
      Location:170 → 296
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:298 → 360
      Cyclin_C; Cyclin, C-terminal domain
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N

    9. XM_006500950.5 → XP_006501013.1  cyclin-A1 isoform X1

      See identical proteins and their annotated locations for XP_006501013.1

      UniProtKB/Swiss-Prot
      Q61456, Q8C5U1
      Conserved Domains (3) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    10. XM_006500949.4 → XP_006501012.1  cyclin-A1 isoform X1

      Conserved Domains (3) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    11. XM_036162873.1 → XP_036018766.1  cyclin-A1 isoform X1

      UniProtKB/Swiss-Prot
      Q61456, Q8C5U1
      Conserved Domains (3) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    12. XM_036162874.1 → XP_036018767.1  cyclin-A1 isoform X4

      Conserved Domains (2) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cl40454
      Location:132 → 270
      CYCLIN_SF; Cyclin box fold superfamily

    13. XM_030252401.1 → XP_030108261.1  cyclin-A1 isoform X3

      Conserved Domains (3) summary
      COG5024
      Location:134 → 386
      COG5024; Cyclin [Cell division and chromosome partitioning]
      pfam00134
      Location:170 → 272
      Cyclin_N; Cyclin, N-terminal domain
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N

    RNA

    1. XR_003954275.2 RNA Sequence

    2. XR_004941269.1 RNA Sequence

    3. XR_004941268.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61456.2 GenPept UniProtKB/Swiss-Prot:Q61456

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