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    Asgr1 asialoglycoprotein receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 11889, updated on 23-Jun-2021

    Summary

    Official Symbol
    Asgr1provided by MGI
    Official Full Name
    asialoglycoprotein receptor 1provided by MGI
    Primary source
    MGI:MGI:88081
    See related
    Ensembl:ENSMUSG00000020884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; AS; Asg; Asgr; HL-1; ASGPR1; Asgr-1
    Expression
    Biased expression in liver adult (RPKM 70.2) and liver E18 (RPKM 23.8) See more
    NEW
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    Try the new Transcript table

    Genomic context

    See Asgr1 in Genome Data Viewer
    Location:
    11 B3; 11 42.98 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69939735..69948721)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70048909..70057895)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (69867871..69871396)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene acyl-Coenzyme A dehydrogenase, very long chain Neighboring gene microRNA 324 Neighboring gene discs large MAGUK scaffold protein 4 Neighboring gene predicted gene, 32946 Neighboring gene asialoglycoprotein receptor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables asialoglycoprotein receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to extracellular stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    asialoglycoprotein receptor 1
    Names
    hepatic lectin 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291131.1NP_001278060.1  asialoglycoprotein receptor 1 isoform a

      See identical proteins and their annotated locations for NP_001278060.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AK132959, AL596185
      Consensus CDS
      CCDS24933.1
      UniProtKB/Swiss-Prot
      P34927
      Related
      ENSMUSP00000121842.3, ENSMUST00000146411.9
      Conserved Domains (2) summary
      cd03590
      Location:153278
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:15143
      Lectin_N; Hepatic lectin, N-terminal domain
    2. NM_001291132.1NP_001278061.1  asialoglycoprotein receptor 1 isoform b

      See identical proteins and their annotated locations for NP_001278061.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
      Source sequence(s)
      AK132959, AL596185
      Consensus CDS
      CCDS70224.1
      UniProtKB/Swiss-Prot
      P34927
      UniProtKB/TrEMBL
      B1AR34
      Related
      ENSMUSP00000104226.3, ENSMUST00000108585.9
      Conserved Domains (2) summary
      cd03590
      Location:124249
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:15118
      Lectin_N; Hepatic lectin, N-terminal domain
    3. NM_009714.3NP_033844.1  asialoglycoprotein receptor 1 isoform a

      See identical proteins and their annotated locations for NP_033844.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AK132959, AL596185
      Consensus CDS
      CCDS24933.1
      UniProtKB/Swiss-Prot
      P34927
      Related
      ENSMUSP00000018699.7, ENSMUST00000018699.13
      Conserved Domains (2) summary
      cd03590
      Location:153278
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:15143
      Lectin_N; Hepatic lectin, N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69939735..69948721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314231.1XP_017169720.1  asialoglycoprotein receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      P34927
      Conserved Domains (2) summary
      cd03590
      Location:153278
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:15143
      Lectin_N; Hepatic lectin, N-terminal domain
    2. XM_036156250.1XP_036012143.1  asialoglycoprotein receptor 1 isoform X1

      Conserved Domains (2) summary
      cd03590
      Location:153278
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:15143
      Lectin_N; Hepatic lectin, N-terminal domain
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