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    Eno2 enolase 2, gamma neuronal [ Mus musculus (house mouse) ]

    Gene ID: 13807, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Eno2provided by MGI
    Official Full Name
    enolase 2, gamma neuronalprovided by MGI
    Primary source
    MGI:MGI:95394
    See related
    Ensembl:ENSMUSG00000004267 AllianceGenome:MGI:95394
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NSE; Eno-2; D6Ertd375e
    Summary
    Predicted to enable enzyme binding activity; identical protein binding activity; and phosphopyruvate hydratase activity. Predicted to be involved in canonical glycolysis; gluconeogenesis; and negative regulation of neuron death. Located in cytoplasm; perikaryon; and photoreceptor inner segment. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human ENO2 (enolase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 147.0), frontal lobe adult (RPKM 120.3) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eno2 in Genome Data Viewer
    Location:
    6 F2; 6 59.17 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124737018..124746489, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124760053..124769673, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8991 Neighboring gene U7 small nuclear RNA Neighboring gene atrophin 1 Neighboring gene STARR-seq mESC enhancer starr_17303 Neighboring gene leucine rich repeat containing 23 Neighboring gene predicted gene, 38895 Neighboring gene predicted gene, 38894

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Continuous neurogenesis in the adult forebrain is required for innate olfactory responses. Sakamoto M, et al. Proc Natl Acad Sci U S A, 2011 May 17. PMID 21536899, Free PMC Article
    2. Induction of neuron-specific enolase promoter and neuronal markers in differentiated mouse bone marrow stromal cells. Levy YS, et al. J Mol Neurosci, 2003. PMID 14593212
    3. Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development. Gao L, et al. J Exp Clin Cancer Res, 2023 Jan 2. PMID 36588153, Free PMC Article
    4. miR‑153 promotes neural differentiation in the mouse hippocampal HT‑22 cell line and increases the expression of neuron‑specific enolase. Xu C, et al. Mol Med Rep, 2019 Aug. PMID 31257504, Free PMC Article
    5. New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration. Kaneko N, et al. Sci Adv, 2018 Dec. PMID 30547091, Free PMC Article

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development.
      Title: Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development.
    2. miR153 promoted neural differentiation and protected neural cells by upregulating the neuron markers gammaenolase, neuronal nuclei, and the functional proteins SNAP23, SNAP25 and PRX5.
      Title: miR‑153 promotes neural differentiation in the mouse hippocampal HT‑22 cell line and increases the expression of neuron‑specific enolase.
    3. Study analyzed the regions that regulate the promoter strength and cellular specificity of the 1.8 kb rNSE promoter in the cerebellum in vivo. The rNSE promoter was divided into three regions (A, B, and C). Our results showed that region C was indispensable for the promoter activity in mouse cerebellum and served as an interneuron-predominant basal promoter.
      Title: Viral Vector-Based Evaluation of Regulatory Regions in the Neuron-Specific Enolase (NSE) Promoter in Mouse Cerebellum In Vivo.
    4. Plaque-associated microglial cells express gamma-enolase and cathepsin X.
      Title: Neuroprotective role of γ-enolase in microglia in a mouse model of Alzheimer's disease is regulated by cathepsin X.
    5. Treadmill exercise training decreased the expression of NSN in the striatum of chronic Parkinsonian mice, which can partially explain the beneficial neuroprotective role of exercise in patients with parkinson disease.
      Title: Effect of endurance exercise training on the expression of GFAP, S100B, and NSE in the striatum of chronic/progressive mouse model of Parkinson's disease.
    6. we induced differentiation of mouse stromal cells to neuron-like cells and observed the activation of tissue-specific promoter of neuron-specific enolase in transgenic mice with the human bcl-2 gene expressed only in neurons under the NSE promoter
      Title: Induction of neuron-specific enolase promoter and neuronal markers in differentiated mouse bone marrow stromal cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (11) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopyruvate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphopyruvate hydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical glycolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myelin sheath HDA PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phosphopyruvate hydratase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphopyruvate hydratase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gamma-enolase
    Names
    2-phospho-D-glycerate hydro-lyase
    neural enolase
    neuron-specific enolase
    NP_001289571.1
    NP_001342149.1
    NP_001396615.1
    NP_001396616.1
    NP_001396617.1
    NP_001396618.1
    NP_001396619.1
    NP_038537.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302642.2 → NP_001289571.1  gamma-enolase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the coding region compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1. Variants 2, 7, and 8 all encode the same isoform (2).
      Source sequence(s)
      AC164157
      Consensus CDS
      CCDS80609.1
      UniProtKB/TrEMBL
      D3Z6E4, Q922A0
      Related
      ENSMUSP00000108095.2, ENSMUST00000112476.8
      Conserved Domains (1) summary
      PLN00191
      Location:2 → 313
      PLN00191; enolase

    2. NM_001355220.2 → NP_001342149.1  gamma-enolase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 3-6 all encode the same isoform (1).
      Source sequence(s)
      AC164157
      Consensus CDS
      CCDS20527.1
      UniProtKB/Swiss-Prot
      P17183
      UniProtKB/TrEMBL
      Q3UJ20, Q545V3
      Conserved Domains (1) summary
      PLN00191
      Location:2 → 432
      PLN00191; enolase

    3. NM_001409686.1 → NP_001396615.1  gamma-enolase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC164157
      UniProtKB/Swiss-Prot
      P17183
      UniProtKB/TrEMBL
      Q545V3

    4. NM_001409687.1 → NP_001396616.1  gamma-enolase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC164157
      UniProtKB/Swiss-Prot
      P17183
      UniProtKB/TrEMBL
      Q545V3

    5. NM_001409688.1 → NP_001396617.1  gamma-enolase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC164157
      UniProtKB/Swiss-Prot
      P17183
      UniProtKB/TrEMBL
      Q545V3

    6. NM_001409689.1 → NP_001396618.1  gamma-enolase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164157
      UniProtKB/TrEMBL
      D3Z6E4

    7. NM_001409690.1 → NP_001396619.1  gamma-enolase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164157
      UniProtKB/TrEMBL
      D3Z6E4

    8. NM_013509.4 → NP_038537.1  gamma-enolase isoform 1

      See identical proteins and their annotated locations for NP_038537.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3-6 all encode the same isoform (1).
      Source sequence(s)
      AC164157
      Consensus CDS
      CCDS20527.1
      UniProtKB/Swiss-Prot
      P17183
      UniProtKB/TrEMBL
      Q3UJ20, Q545V3
      Related
      ENSMUSP00000004378.9, ENSMUST00000004378.15
      Conserved Domains (1) summary
      PLN00191
      Location:2 → 432
      PLN00191; enolase

    RNA

    1. NR_176885.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC164157

    2. NR_176886.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC164157

    3. NR_176887.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC164157

    4. NR_176888.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC164157

    5. NR_176889.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC164157

    6. NR_176890.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC164157

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      124737018..124746489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17183.2 GenPept UniProtKB/Swiss-Prot:P17183

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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