Fcna ficolin A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fcnaprovided by MGI
Official Full Name: ficolin Aprovided by MGI
Primary source: MGI:MGI:1340905
See related: Ensembl:ENSMUSG00000026938 AllianceGenome:MGI:1340905
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fcn1
Summary: Enables carbohydrate derivative binding activity. Acts upstream of or within complement activation, lectin pathway. Predicted to be extrinsic component of external side of plasma membrane. Predicted to be part of collagen trimer. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in brain; embryo; liver; and spleen. Orthologous to human FCN1 (ficolin 1) and FCN2 (ficolin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 38.4), spleen adult (RPKM 36.2) and 10 other tissues See more
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Genomic context

Location:: 2 A3; 2 17.58 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (25514677..25525448, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (25624665..25635440, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ficolin A knockout alleviates sepsis-induced severe lung injury in mice by restoring gut Akkermansia to inhibit S100A4/STAT3 pathway.
Title: Ficolin A knockout alleviates sepsis-induced severe lung injury in mice by restoring gut Akkermansia to inhibit S100A4/STAT3 pathway.
FCN-A mediates the inflammatory response and the macrophage polarization in Aspergillus fumigatus keratitis of mice by activating the MAPK signaling pathway.
Title: FCN-A mediates the inflammatory response and the macrophage polarization in Aspergillus fumigatus keratitis of mice by activating the MAPK signaling pathway.
Lipopolysaccharide-induced inflammation can induce a significant ficolin response.
Title: The ficolin response to LPS challenge in mice.
Ficolin-2 induces macrophage activation, promotes M1 polarization and facilitates proliferation and antigen-specific cytotoxicity of CD8(+) T cells. Ficolin-2 binds to Toll-like receptor 4 (TLR4) on macrophages and DCs and promotes their antigen-presenting abilities to CD8(+) T cells.
Title: Ficolin-2 triggers antitumor effect by activating macrophages and CD8(+) T cells.
this study demonstrates that ficolins are important in initial innate host defense against Aspergillus fumigatus infections in vivo
Title: Ficolins Promote Fungal Clearance in vivo and Modulate the Inflammatory Cytokine Response in Host Defense against Aspergillus fumigatus.
this study shows that FCN-A/2 exacerbated the inflammatory pathogenesis of inflammatory bowel disease by stimulating M1 polarization through the TLR4/MyD88/MAPK/NF-kappaB signalling pathway in macrophages
Title: Ficolin-A/2, acting as a new regulator of macrophage polarization, mediates the inflammatory response in experimental mouse colitis.
FcnA-deficient and FcnA/ficolin B double-deficient mice lack FcnA-mediated complement activation in the sera, because of absence of complexes comprising FcnA and MBL-associated serine proteases.
Title: Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection.
the binding properties of the murine serum ficolin-A towards a panel of different clinical relevant microorganisms
Title: The interaction pattern of murine serum ficolin-A with microorganisms.
binds to the glycoproteins hemagglutinin and neuraminidase and inhibits influenza A virus infection both in vitro and in vivo
Title: L-ficolin binds to the glycoproteins hemagglutinin and neuraminidase and inhibits influenza A virus infection both in vitro and in vivo.
Recombinant mouse ficolin A, mannose-binding lectin-A, and mannose-binding lectin-C bound to fibrinogen in a dose-dependent manner. The lectin pathway, through mannose-binding lectins, synchronized with blood coagulation.
Title: Interactions of ficolin and mannose-binding lectin with fibrinogen/fibrin augment the lectin complement pathway.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fcna (e-PCR), detects polymorphism
- UniSTS:471077

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables carbohydrate derivative binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in complement activation, lectin pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ficolin-1

Names: M-ficolin; collagen/fibrinogen domain-containing protein 1; ficolin-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001420084.1 → NP_001407013.1 ficolin-1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL732590
NM_007995.4 → NP_032021.1 ficolin-1 isoform 1 precursor

See identical proteins and their annotated locations for NP_032021.1

Status: VALIDATED

Source sequence(s)

AL732590

Consensus CDS

CCDS15785.1

UniProtKB/Swiss-Prot

O70165

UniProtKB/TrEMBL

Q2WFW2, Q4FJM1

Related

ENSMUSP00000028307.9, ENSMUST00000028307.9

Conserved Domains (2) summary

pfam01391
Location:65 → 106

Collagen; Collagen triple helix repeat (20 copies)

cd00087
Location:123 → 332

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

25514677..25525448 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011239016.4 → XP_011237318.1 ficolin-1 isoform X1

See identical proteins and their annotated locations for XP_011237318.1

UniProtKB/Swiss-Prot

O70165

UniProtKB/TrEMBL

Q2WFW2, Q4FJM1

Conserved Domains (2) summary

pfam01391
Location:65 → 106

Collagen; Collagen triple helix repeat (20 copies)

cd00087
Location:123 → 332

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
XM_006497673.5 → XP_006497736.1 ficolin-1 isoform X1

See identical proteins and their annotated locations for XP_006497736.1

UniProtKB/Swiss-Prot

O70165

UniProtKB/TrEMBL

Q2WFW2, Q4FJM1

Conserved Domains (2) summary

pfam01391
Location:65 → 106

Collagen; Collagen triple helix repeat (20 copies)

cd00087
Location:123 → 332

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...