Dock7 dedicator of cytokinesis 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dock7provided by MGI
Official Full Name: dedicator of cytokinesis 7provided by MGI
Primary source: MGI:MGI:1914549
See related: Ensembl:ENSMUSG00000028556 AllianceGenome:MGI:1914549
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm430; 3110056M06Rik
Summary: Enables small GTPase binding activity. Involved in interkinetic nuclear migration; negative regulation of cold-induced thermogenesis; and regulation of neurogenesis. Acts upstream of or within hematopoietic progenitor cell differentiation and pigmentation. Predicted to be located in cell projection. Predicted to be part of COP9 signalosome. Is expressed in several structures, including alimentary system; central nervous system; lung; placenta; and sensory organ. Used to study platelet storage pool deficiency. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 23. Orthologous to human DOCK7 (dedicator of cytokinesis 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E14 (RPKM 16.9), whole brain E14.5 (RPKM 15.8) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C6; 4 45.6 cM

Exon count:: 52

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (98824669..99019190, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (98936659..99130953, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice.
Title: A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice.
These studies establish Dock7 as a critical regulator of both cortical and trabecular bone mass.
Title: Spontaneous mutation of Dock7 results in lower trabecular bone mass and impaired periosteal expansion in aged female Misty mice.
DOCK7 controls neuronal growth via a Rac-dependent pathway, likely by modulating microtubule networks while also regulating F-actin remodeling at the cell rear to promote somal translocation via a previously unrecognized myosin phosphatase-RhoA-interacting protein-dependent pathway.
Title: Dual role for DOCK7 in tangential migration of interneuron precursors in the postnatal forebrain.
DOCK7 acts as a cytoplasmic activator of the ErbB4 and is essential for chandelier cell cartridge and bouton development.
Title: Regulation of chandelier cell cartridge and bouton development via DOCK7-mediated ErbB4 activation.
DOCK7 interaction with TACC3 controls interkinetic nuclear migration and the genesis of neurons from radial glial progenitor cells during cortical development
Title: DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.
The results of this study identified Dock7 as a novel regulator of Schwann cell differentiation and the onset of myelination both in vitro and in vivo.
Title: The atypical Guanine-nucleotide exchange factor, dock7, negatively regulates schwann cell differentiation and myelination.
Although Dock7 is transcribed at high levels in the developing brain and has been implicated in both axon development and myelination by in vitro studies, we find no requirement for DOCK7 in neurobehavioral function in vivo
Title: Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function.

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Phenotypes

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Associated conditions

Description	Tests
misty GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2) 1 citation
Targeted (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU022169 (e-PCR)
- UniSTS:207644

AL009364 (e-PCR)
- UniSTS:15687

RH135495 (e-PCR)
- UniSTS:209822

NoName (e-PCR)
- UniSTS:234966

Dock7 (e-PCR), detects polymorphism
- UniSTS:548058

35.MMHAP15FRD11.seq (e-PCR)
- UniSTS:124129

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in establishment of neuroblast polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in interkinetic nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic specialization assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic specialization assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: dedicator of cytokinesis protein 7

Names: protein moonlight

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290636.2 → NP_001277565.1 dedicator of cytokinesis protein 7 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL627349, AL627393, AL935325

Consensus CDS

CCDS71425.1

UniProtKB/Swiss-Prot

Q45V78, Q5PRE6, Q6PJ17, Q8R1A4, Q9CSB6, Q9CXM7

UniProtKB/TrEMBL

A2A9M5

Related

ENSMUSP00000030286.8, ENSMUST00000030286.14

Conserved Domains (3) summary

cd08696
Location:560 → 737

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11703
Location:1634 → 2106

DHR2_DOCK7; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 7

pfam11878
Location:70 → 159

DUF3398; Domain of unknown function (DUF3398)
NM_001369285.2 → NP_001356214.1 dedicator of cytokinesis protein 7 isoform 3

Status: VALIDATED

Source sequence(s)

AL627349, AL627393, AL935325

UniProtKB/Swiss-Prot

Q45V78, Q5PRE6, Q6PJ17, Q8R1A4, Q9CSB6, Q9CXM7

Conserved Domains (3) summary

cd08696
Location:560 → 737

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11703
Location:1604 → 2078

DHR2_DOCK7; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 7

pfam11878
Location:72 → 159

DUF3398; Domain of unknown function (DUF3398)
NM_001369286.2 → NP_001356215.1 dedicator of cytokinesis protein 7 isoform 4

Status: VALIDATED

Source sequence(s)

AL627349, AL627393, AL935325

Consensus CDS

CCDS89783.1

UniProtKB/Swiss-Prot

Q45V78, Q5PRE6, Q6PJ17, Q8R1A4, Q9CSB6, Q9CXM7

UniProtKB/TrEMBL

A2A9M4

Related

ENSMUSP00000117797.3, ENSMUST00000127417.3

Conserved Domains (3) summary

cd08696
Location:560 → 737

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11703
Location:1634 → 2108

DHR2_DOCK7; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 7

pfam11878
Location:72 → 159

DUF3398; Domain of unknown function (DUF3398)
NM_026082.6 → NP_080358.3 dedicator of cytokinesis protein 7 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.

Source sequence(s)

AL627349, AL627393, AL935325

Consensus CDS

CCDS38816.1

UniProtKB/Swiss-Prot

Q45V78, Q5PRE6, Q6PJ17, Q8R1A4, Q9CSB6, Q9CXM7

UniProtKB/TrEMBL

A0A0U1RNK7

Related

ENSMUSP00000145604.2, ENSMUST00000205650.2

Conserved Domains (3) summary

cd08696
Location:560 → 737

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11703
Location:1604 → 2076

DHR2_DOCK7; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 7

pfam11878
Location:70 → 159

DUF3398; Domain of unknown function (DUF3398)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

98824669..99019190 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503314.5 → XP_006503377.1 dedicator of cytokinesis protein 7 isoform X6

UniProtKB/Swiss-Prot

Q45V78, Q5PRE6, Q6PJ17, Q8R1A4, Q9CSB6, Q9CXM7

UniProtKB/TrEMBL

E9PX48

Related

ENSMUSP00000075233.7, ENSMUST00000075836.12

Conserved Domains (3) summary

cd08696
Location:560 → 737

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11703
Location:1604 → 2078

DHR2_DOCK7; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 7

pfam11878
Location:52 → 161

DUF3398; Domain of unknown function (DUF3398)
XM_036164363.1 → XP_036020256.1 dedicator of cytokinesis protein 7 isoform X5

UniProtKB/Swiss-Prot

Q45V78, Q5PRE6, Q6PJ17, Q8R1A4, Q9CSB6, Q9CXM7

Conserved Domains (3) summary

cd08696
Location:560 → 737

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11703
Location:1616 → 2088

DHR2_DOCK7; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 7

pfam11878
Location:52 → 161

DUF3398; Domain of unknown function (DUF3398)
XM_006503313.5 → XP_006503376.1 dedicator of cytokinesis protein 7 isoform X4

UniProtKB/Swiss-Prot

Q45V78, Q5PRE6, Q6PJ17, Q8R1A4, Q9CSB6, Q9CXM7

Conserved Domains (3) summary

cd08696
Location:560 → 737

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11703
Location:1616 → 2090

DHR2_DOCK7; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 7

pfam11878
Location:52 → 161

DUF3398; Domain of unknown function (DUF3398)
XM_006503310.5 → XP_006503373.1 dedicator of cytokinesis protein 7 isoform X3

UniProtKB/Swiss-Prot

Q45V78, Q5PRE6, Q6PJ17, Q8R1A4, Q9CSB6, Q9CXM7

Conserved Domains (3) summary

cd08696
Location:560 → 737

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11703
Location:1646 → 2115

DHR2_DOCK7; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 7

pfam11878
Location:52 → 161

DUF3398; Domain of unknown function (DUF3398)
XM_006503309.5 → XP_006503372.1 dedicator of cytokinesis protein 7 isoform X2

UniProtKB/Swiss-Prot

Q45V78, Q5PRE6, Q6PJ17, Q8R1A4, Q9CSB6, Q9CXM7

Conserved Domains (3) summary

cd08696
Location:560 → 737

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11703
Location:1646 → 2118

DHR2_DOCK7; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 7

pfam11878
Location:52 → 161

DUF3398; Domain of unknown function (DUF3398)
XM_006503308.5 → XP_006503371.1 dedicator of cytokinesis protein 7 isoform X1

UniProtKB/Swiss-Prot

Q45V78, Q5PRE6, Q6PJ17, Q8R1A4, Q9CSB6, Q9CXM7

Conserved Domains (3) summary

cd08696
Location:560 → 737

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11703
Location:1646 → 2120

DHR2_DOCK7; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 7

pfam11878
Location:52 → 161

DUF3398; Domain of unknown function (DUF3398)
XM_017320362.3 → XP_017175851.1 dedicator of cytokinesis protein 7 isoform X7

UniProtKB/Swiss-Prot

Q45V78, Q5PRE6, Q6PJ17, Q8R1A4, Q9CSB6, Q9CXM7

Conserved Domains (3) summary

cd08696
Location:452 → 629

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11703
Location:1538 → 2012

DHR2_DOCK7; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 7

pfam11878
Location:1 → 53

DUF3398; Domain of unknown function (DUF3398)
XM_030253721.2 → XP_030109581.1 dedicator of cytokinesis protein 7 isoform X9

Conserved Domains (2) summary

cd11703
Location:990 → 1464

DHR2_DOCK7; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 7

cl14603
Location:10 → 123

C2; C2 domain
XM_030253720.2 → XP_030109580.1 dedicator of cytokinesis protein 7 isoform X8

Conserved Domains (2) summary

cd11703
Location:1032 → 1506

DHR2_DOCK7; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 7

cl14603
Location:10 → 123

C2; C2 domain
XM_036164364.1 → XP_036020257.1 dedicator of cytokinesis protein 7 isoform X10

Conserved Domains (2) summary

cd08696
Location:560 → 737

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

pfam11878
Location:52 → 161

DUF3398; Domain of unknown function (DUF3398)