D7Ertd443e DNA segment, Chr 7, ERATO Doi 443, expressed [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: D7Ertd443eprovided by MGI
Official Full Name: DNA segment, Chr 7, ERATO Doi 443, expressedprovided by MGI
Primary source: MGI:MGI:1196431
See related: Ensembl:ENSMUSG00000030994 AllianceGenome:MGI:1196431
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FATS; Gm497; 4933400E14Rik
Summary: Enables histone deacetylase binding activity and ubiquitin protein ligase activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; protein stabilization; and response to ionizing radiation. Predicted to be located in several cellular components, including actin cytoskeleton; nucleoplasm; and plasma membrane. Predicted to be active in centriole; centrosome; and cytosol. Orthologous to human C10orf90 (chromosome 10 open reading frame 90). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 9.5) and cerebellum adult (RPKM 0.7) See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 78.4 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (133867509..134121888, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (134265780..134520159, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization.
Title: Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization.
FATS expression was silent or downregulated in human cancers, and overexpression of FATS suppressed tumorigenicity in vivo independently of p53. Results reveal FATS as a p53-regulated gene to monitor genomic stability.
Title: FATS is a transcriptional target of p53 and associated with antitumor activity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone deacetylase binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic G2 DNA damage checkpoint signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of centriole replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to UV	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ionizing radiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: (E2-independent) E3 ubiquitin-conjugating enzyme FATS

Names: E2/E3 hybrid ubiquitin-protein ligase FATS; centrosomal protein C10orf90 homolog; fragile-site associated tumor suppressor homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081331.2 → NP_001074800.1 (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 2

See identical proteins and their annotated locations for NP_001074800.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC124369, AC126676

Consensus CDS

CCDS57590.1

UniProtKB/Swiss-Prot

D2J0Y4

UniProtKB/TrEMBL

Q3ULM5

Related

ENSMUSP00000091539.4, ENSMUST00000094002.10

Conserved Domains (2) summary

pfam15309
Location:514 → 641

ALMS_motif; ALMS motif

pfam17730
Location:5 → 509

Centro_C10orf90; Centrosomal C10orf90
NM_001199941.1 → NP_001186870.1 (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

GQ499374

Consensus CDS

CCDS57591.1

UniProtKB/TrEMBL

G3UZF7, Q3ULM5

Related

ENSMUSP00000134479.2, ENSMUST00000172947.8

Conserved Domains (1) summary

pfam15309
Location:561 → 689

ALMS_motif; ALMS motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

133867509..134121888 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241903.3 → XP_011240205.1 (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X3

UniProtKB/TrEMBL

Q3ULM5

Conserved Domains (2) summary

pfam15309
Location:530 → 657

ALMS_motif; ALMS motif

pfam17730
Location:21 → 525

Centro_C10orf90; Centrosomal C10orf90
XM_011241905.4 → XP_011240207.1 (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X4

See identical proteins and their annotated locations for XP_011240207.1

UniProtKB/Swiss-Prot

D2J0Y4

UniProtKB/TrEMBL

Q3ULM5

Conserved Domains (2) summary

pfam15309
Location:514 → 641

ALMS_motif; ALMS motif

pfam17730
Location:5 → 509

Centro_C10orf90; Centrosomal C10orf90
XM_011241901.2 → XP_011240203.1 (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X1

See identical proteins and their annotated locations for XP_011240203.1

UniProtKB/TrEMBL

Q3ULM5

Conserved Domains (2) summary

pfam15309
Location:591 → 718

ALMS_motif; ALMS motif

pfam17730
Location:82 → 586

Centro_C10orf90; Centrosomal C10orf90
XM_011241906.3 → XP_011240208.1 (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X5

UniProtKB/TrEMBL

Q3ULM5

Conserved Domains (2) summary

pfam15309
Location:496 → 623

ALMS_motif; ALMS motif

pfam17730
Location:82 → 491

Centro_C10orf90; Centrosomal C10orf90
XM_011241902.4 → XP_011240204.1 (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X2

UniProtKB/TrEMBL

Q3ULM5

Conserved Domains (2) summary

pfam15309
Location:545 → 672

ALMS_motif; ALMS motif

pfam17730
Location:36 → 540

Centro_C10orf90; Centrosomal C10orf90
XM_011241904.4 → XP_011240206.1 (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X4

See identical proteins and their annotated locations for XP_011240206.1

UniProtKB/Swiss-Prot

D2J0Y4

UniProtKB/TrEMBL

Q3ULM5

Conserved Domains (2) summary

pfam15309
Location:514 → 641

ALMS_motif; ALMS motif

pfam17730
Location:5 → 509

Centro_C10orf90; Centrosomal C10orf90
XM_011241907.4 → XP_011240209.1 (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X6

See identical proteins and their annotated locations for XP_011240209.1

UniProtKB/TrEMBL

F7AZE7, Q9D4E0

Related

ENSMUSP00000101735.3, ENSMUST00000106129.9

Conserved Domains (2) summary

pfam15309
Location:155 → 282

ALMS_motif; ALMS motif

pfam17730
Location:3 → 150

Centro_C10orf90; Centrosomal C10orf90