Clec4a3 C-type lectin domain family 4, member a3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec4a3provided by MGI
Official Full Name: C-type lectin domain family 4, member a3provided by MGI
Primary source: MGI:MGI:1920399
See related: Ensembl:ENSMUSG00000043832 AllianceGenome:MGI:1920399
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dcir3; 3110037K17Rik
Summary: Predicted to enable calcium ion binding activity and mannose binding activity. Predicted to be involved in several processes, including antifungal innate immune response; negative regulation of tumor necrosis factor production; and plasmacytoid dendritic cell antigen processing and presentation. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC4A (C-type lectin domain family 4 member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 1.7), mammary gland adult (RPKM 1.6) and 19 other tissues See more
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Genomic context

Location:: 6 F2; 6 58.04 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (122929474..122946837)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (122952515..122969878)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The anti- DCIR3 antibody established in this study, together with the previously established anti-DCIR1 and anti-DCIR4 antibodies, would be a valuable tool to investigate biology and pathophysiology of monocytes.
Title: DCIR3 and DCIR4 are co-expressed on inflammatory and patrolling monocytes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables mannose binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antifungal innate immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dendritic cell inhibitory receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001204241.1 → NP_001191170.1 dendritic cell inhibitory receptor 3

See identical proteins and their annotated locations for NP_001191170.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BC034893

Consensus CDS

CCDS20508.1

UniProtKB/TrEMBL

Q5YIR7, Q8JZX6

Related

ENSMUSP00000112716.2, ENSMUST00000117173.8

Conserved Domains (2) summary

cd03590
Location:107 → 230

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam10332
Location:41 → 82

DUF2418; Protein of unknown function (DUF2418)
NM_153197.4 → NP_694877.2 dendritic cell inhibitory receptor 3

See identical proteins and their annotated locations for NP_694877.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK156040, BC034893

Consensus CDS

CCDS20508.1

UniProtKB/TrEMBL

Q5YIR7, Q8JZX6

Related

ENSMUSP00000085816.5, ENSMUST00000088468.7

Conserved Domains (2) summary

cd03590
Location:107 → 230

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam10332
Location:41 → 82

DUF2418; Protein of unknown function (DUF2418)